Cellular and molecular control of tooth morphogenesis
牙齿形态发生的细胞和分子控制
基本信息
- 批准号:10614175
- 负责人:
- 金额:$ 3.07万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-07-01 至 2022-09-30
- 项目状态:已结题
- 来源:
- 关键词:AnteriorApoptosisAtlasesAutomobile DrivingBehaviorBiologicalBiological ModelsBiomedical EngineeringBrainCell ProliferationCell ShapeCell SizeCell divisionCell physiologyCellsDataDental cariesDevelopmentEctopic ExpressionEpithelialEventFeedbackFibroblast Growth FactorFibroblast Growth Factor ReceptorsFoundationsFutureGenesGeneticGenetic RecombinationGoalsImageIncisorKnock-outKnowledgeLearningLinkMapsMeasurementMeasuresMesenchymeMethodsMolar toothMolecularMorphogenesisMorphologyMotionMusMuscleMutationMyosin ATPaseNuclearOral cavityOrganOrganogenesisOutcomeOutputPhenotypeProcessPublic HealthRelaxationResolutionRoleSHH geneShapesSignal PathwaySignal TransductionSpecimenStressStructureStudy modelsSyndromeTestingTissuesTooth LossTooth structureUp-Regulationbasebonecell behaviorcell motilitycraniofacialinhibitorintercalationinterestloss of functionmechanical forcemutantpublic health relevanceregenerative therapyrepairedsmoothened signaling pathwaytool
项目摘要
ABSTRACT
Tooth bioengineering is of great interest, because dental decay and tooth loss constitute an important public
health issue. Additionally, tooth anomalies are common in many craniofacial syndromes, and the easy
accessibility of the oral cavity makes teeth an excellent test case for organ replacement. A thorough
understanding of the molecular and cellular processes that drive tooth development will be crucial to efforts to
build and repair teeth. The initial step in tooth development involves epithelial invagination that, while
representative of a fundamental and widespread morphogenetic motif utilized throughout development, also
demonstrates important differences among tooth types. We propose to analyze the early, asymmetrical
invagination events in the incisor teeth and to contrast these with the symmetrical invagination of the molar teeth.
In Specific Aim 1, we will define the cell dynamics (motions and forces) distinguishing incisor vs. molar formation.
In Specific Aim 2, we will determine the mechanism by which FGF signaling modulation controls tooth
morphogenesis. In Specific Aim 3, we will apply the spatial and directional effects of FGF and Shh signaling to
modify tooth shape.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
JEREMY B.A. GREEN其他文献
JEREMY B.A. GREEN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('JEREMY B.A. GREEN', 18)}}的其他基金
Cellular and molecular control of tooth morphogenesis
牙齿形态发生的细胞和分子控制
- 批准号:
10303191 - 财政年份:2021
- 资助金额:
$ 3.07万 - 项目类别:
Cellular and molecular control of tooth morphogenesis
牙齿形态发生的细胞和分子控制
- 批准号:
10614530 - 财政年份:2019
- 资助金额:
$ 3.07万 - 项目类别:
Cellular and molecular control of tooth morphogenesis
牙齿形态发生的细胞和分子控制
- 批准号:
10388289 - 财政年份:2019
- 资助金额:
$ 3.07万 - 项目类别:
相似国自然基金
Epac1/2通过蛋白酶体调控中性粒细胞NETosis和Apoptosis在急性肺损伤中的作用研究
- 批准号:LBY21H010001
- 批准年份:2020
- 资助金额:0.0 万元
- 项目类别:省市级项目
基于Apoptosis/Ferroptosis双重激活效应的天然产物AlbiziabiosideA的抗肿瘤作用机制研究及其结构改造
- 批准号:81703335
- 批准年份:2017
- 资助金额:20.0 万元
- 项目类别:青年科学基金项目
双肝移植后Apoptosis和pyroptosis在移植物萎缩差异中的作用和供受者免疫微环境变化研究
- 批准号:81670594
- 批准年份:2016
- 资助金额:58.0 万元
- 项目类别:面上项目
Serp-2 调控apoptosis和pyroptosis 对肝脏缺血再灌注损伤的保护作用研究
- 批准号:81470791
- 批准年份:2014
- 资助金额:73.0 万元
- 项目类别:面上项目
Apoptosis signal-regulating kinase 1是七氟烷抑制小胶质细胞活化的关键分子靶点?
- 批准号:81301123
- 批准年份:2013
- 资助金额:23.0 万元
- 项目类别:青年科学基金项目
APO-miR(multi-targeting apoptosis-regulatory miRNA)在前列腺癌中的表达和作用
- 批准号:81101529
- 批准年份:2011
- 资助金额:22.0 万元
- 项目类别:青年科学基金项目
放疗与细胞程序性死亡(APOPTOSIS)相关性及其应用研究
- 批准号:39500043
- 批准年份:1995
- 资助金额:9.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Development of an apoptosis biosensor for monitoring of breast cancer
开发用于监测乳腺癌的细胞凋亡生物传感器
- 批准号:
10719415 - 财政年份:2023
- 资助金额:
$ 3.07万 - 项目类别:
Milk fat globule-EGF factor 8 and hepatocyte apoptosis-induced liver wound healing response
乳脂肪球-EGF因子8与肝细胞凋亡诱导的肝脏创面愈合反应
- 批准号:
10585802 - 财政年份:2023
- 资助金额:
$ 3.07万 - 项目类别:
Interrogating the Fgl2-FcγRIIB axis on CD8+ T cells: A novel mechanism mediating apoptosis of tumor-specific memory CD8+ T cells
询问 CD8 T 细胞上的 Fgl2-FcγRIIB 轴:介导肿瘤特异性记忆 CD8 T 细胞凋亡的新机制
- 批准号:
10605856 - 财政年份:2023
- 资助金额:
$ 3.07万 - 项目类别:
Novel targeted therapy for FGFR inhibitor-resistant urothelial cancer and apoptosis based therapy for urothelial cancer
FGFR抑制剂耐药性尿路上皮癌的新型靶向治疗和基于细胞凋亡的尿路上皮癌治疗
- 批准号:
23K08773 - 财政年份:2023
- 资助金额:
$ 3.07万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Mechanistic analysis of apoptosis induction by HDAC inhibitors in head and neck cancer
HDAC抑制剂诱导头颈癌凋亡的机制分析
- 批准号:
23K15866 - 财政年份:2023
- 资助金额:
$ 3.07万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Interrogating the Fgl2-FcgRIIB axis: A novel mechanism mediating apoptosis of tumor-specific memory CD8+ T cells
探究 Fgl2-FcgRIIB 轴:介导肿瘤特异性记忆 CD8 T 细胞凋亡的新机制
- 批准号:
10743485 - 财政年份:2023
- 资助金额:
$ 3.07万 - 项目类别:
Investigating the role of apoptosis-resistance and the tumor environment on development and maintenance of sacrococcygeal teratomas
研究细胞凋亡抗性和肿瘤环境对骶尾部畸胎瘤发生和维持的作用
- 批准号:
10749797 - 财政年份:2023
- 资助金额:
$ 3.07万 - 项目类别:
The effects of glucose on immune cell apoptosis and mitochondrial membrane potential and the analysis of its mechanism by which glucose might modulate the immune functions.
葡萄糖对免疫细胞凋亡和线粒体膜电位的影响及其调节免疫功能的机制分析。
- 批准号:
22K09076 - 财政年份:2022
- 资助金额:
$ 3.07万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
XAF1 IN P53 SIGNALING, APOPTOSIS AND TUMOR SUPPRESSION
P53 信号传导、细胞凋亡和肿瘤抑制中的 XAF1
- 批准号:
10583516 - 财政年份:2022
- 资助金额:
$ 3.07万 - 项目类别:
Role of Thioredoxin system in regulation of autophagy-apoptosis cross talk in neurons: Uncovering Novel Molecular Interactions.
硫氧还蛋白系统在神经元自噬-凋亡串扰调节中的作用:揭示新的分子相互作用。
- 批准号:
RGPIN-2019-05371 - 财政年份:2022
- 资助金额:
$ 3.07万 - 项目类别:
Discovery Grants Program - Individual