Cutaneous Biology and Skin Disease Training Program

皮肤生物学和皮肤病培训计划

• 批准号: 10615621
• 负责人: SETH J. ORLOW
• 金额: --
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10615621
• 关键词: Biology; Cutaneous; Training Programs; skin disorder

Program Summary/Abstract This training grant is founded on the belief that a new model is needed for training the cutaneous biologists of the future. The model of being either a researcher or a clinician ought to be supplanted by one where talented and enthusiastic individuals have exposure to the information, techniques and colleagues necessary for the growing need for collaborative science. In addition, there is a clear need for a program that is suitable for physician postdoctoral fellows, especially since CTSA funded K awards are extremely limited. We will continue to develop such a cadre through our novel training program with a customized curriculum of investigative and clinically relevant experiences, individually tailored to each trainee and focused on a clinical area or disease process. Specifically, each curriculum will comprise 1) laboratory-based research, guided by their Mentor and Mentoring Committee composed of program members with complementary strengths and expertise; 2) didactics chosen with the translational aspects of that research project in mind; and 3) focused clinical involvement (for physician trainees) complementary to the research project. In addition to providing our trainees with rigorous scientific instruction in the specific area of their choosing, we shall mentor and guide them to ensure a successful transition to productive investigative careers, preparing them for independent skin biology and skin disease related biomedical research. We propose to engage two MD, PhD or MD/PhD trainees annually into a two-year postdoctoral training program with an optional third year. We have assembled a stellar team of mentors in broad areas relevant to cutaneous biology and skin diseases, and an innovative guidance program to ensure that we grow mentors as well as trainees.

项目概要/摘要 这项培训补助金是建立在这样一种信念的基础上，即需要一种新的模式来培训皮肤生物学家， 未来无论是研究人员还是临床医生的模式都应该被一个有才华的人所取代 和热情的个人有机会接触到必要的信息，技术和同事， 日益增长的科学合作需求。此外，显然需要一个适合于 医生博士后研究员，特别是因为CTSA资助的K奖是非常有限的。我们将继续 通过我们新颖的培训计划，以定制的调查课程， 和临床相关经验，为每位学员量身定制并专注于临床领域 或疾病过程。具体来说，每个课程将包括1）实验室为基础的研究，由他们的指导， 导师和导师委员会由具有互补优势的计划成员组成， 专业知识; 2）教学方法的选择与翻译方面的研究项目铭记;和3）重点 临床参与（针对实习医生）是对研究项目的补充。除了提供我们的 学员在他们选择的特定领域进行严格的科学指导，我们将指导和指导 确保他们成功过渡到富有成效的调查职业，为独立的皮肤做好准备。 生物学和皮肤病相关的生物医学研究。我们建议聘请两名MD，PhD或MD/PhD 培训生每年进入一个为期两年的博士后培训计划，可选的第三年。我们已经组建 在皮肤生物学和皮肤疾病相关的广泛领域的一流导师团队，以及创新的 指导计划，以确保我们成长的导师以及学员。

项目成果

MAGE-A3 is a prognostic biomarker for poor clinical outcome in cutaneous squamous cell carcinoma with perineural invasion via modulation of cell proliferation.

• DOI: 10.1371/journal.pone.0241551
• 发表时间: 2020
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Chen A;Santana AL;Doudican N;Roudiani N;Laursen K;Therrien JP;Lee J;Felsen D;Carucci JA
• 通讯作者: Carucci JA

Biophysical Compatibility of a Heterotrimeric Tyrosinase-TYRP1-TYRP2 Metalloenzyme Complex.

• DOI: 10.3389/fphar.2021.602206
• 发表时间: 2021
• 期刊: Frontiers in pharmacology
• 影响因子: 5.6
• 作者: Lavinda O;Manga P;Orlow SJ;Cardozo T
• 通讯作者: Cardozo T

Comparison of comorbidities and adverse events in dermatology and rheumatology patients prescribed tofacitinib: A retrospective analysis.

皮肤病和风湿病患者服用托法替布的合并症和不良事件的比较：回顾性分析。

• DOI: 10.1016/j.jaad.2023.11.027
• 发表时间: 2024
• 期刊: Journal of the American Academy of Dermatology
• 影响因子: 13.8
• 作者: Needle,CarliD;Klein,ElizabethJ;Gjonaj,Jessica;Nohria,Ambika;Karim,Maria;Liu,Lynn;Shah,Jinal;Betensky,RebeccaA;Garshick,Michael;LoSicco,Kristen;Karagounis,TheodoraK
• 通讯作者: Karagounis,TheodoraK

Wound Regeneration Deficit in Rats Correlates with Low Morphogenetic Potential and Distinct Transcriptome Profile of Epidermis.

• DOI: 10.1016/j.jid.2017.12.030
• 发表时间: 2018-06
• 期刊: The Journal of investigative dermatology
• 作者: Guerrero-Juarez CF;Astrowski AA;Murad R;Dang CT;Shatrova VO;Astrowskaja A;Lim CH;Ramos R;Wang X;Liu Y;Lee HL;Pham KT;Hsi TC;Oh JW;Crocker D;Mortazavi A;Ito M;Plikus MV
• 通讯作者: Plikus MV

Melanoma origins: data from early-stage tumours supports de novo and naevus-associated melanomas as distinct subtypes.

黑色素瘤起源：来自早期肿瘤的数据支持新发黑色素瘤和痣相关黑色素瘤是不同的亚型。

• DOI: 10.1111/bjd.20396
• 发表时间: 2021
• 期刊: The British journal of dermatology
• 作者: Wiggins,J;Polsky,D
• 通讯作者: Polsky,D