SWG1: Sex & Gender Working Group

项目摘要/摘要：性与性别科学工作组1 在治疗和未治疗的HIV-1的表现上都有明显的性别和性别差异 感染，但仍然需要明确地确定这些是否由于 免疫反应、对病毒的不同易感性、行为调节剂、荷尔蒙的影响 差异，或所有这些因素的组合。此外，尽管超过50%的艾滋病毒携带者要么是 顺性或变性女性，她们在临床研究中招生不足，极大地限制了我们对性的理解 以及艾滋病毒感染、免疫和潜伏机制、抗逆转录病毒药物反应、 和行为倾向，如由性别不平等的社会经济挑战和 暴力。解决这些关于性别和艾滋病毒性别差异的关键知识差距将有助于 制定有针对性的艾滋病毒预防、治疗和治愈战略，这对实现#年的目标至关重要 在全球范围内根除艾滋病毒感染。CWRU和PIT的艾滋病毒研究社区在当前的合并 申请成立铁锈带CFAR使性别与性别SWG1组装一个特殊的 由基础、临床、翻译和行为调查人员组成的多学科团队，每个人都进行了 至少一项关于性别或性别在艾滋病毒感染或治疗中的作用的研究，或具有与 变性人社区。建立在每个机构独特优势的基础上，性与性别SWG1将发挥作用 与铁锈带CFAR核心密切合作，以实现以下具体目标：(1)与CFAR成员接触 在涉及性别和性别差异的艾滋病毒发病机制的研究中。(2)促进将性和 艾滋病毒治疗、预防和治疗相关研究中的性别差异。(三)战略协调 正式的指导计划，使初级调查人员了解研究性与性别的资源。成功之路 将根据一套明确定义的关键绩效指标对《性别与性别SWG1》进行评估。因此，通过 利用正在进行的强大的艾滋病毒预防、发病机制和治疗研究 锈带CFAR和我们的行为科学和公共卫生专家的结合，性与性别 SWG1非常适合提供对国家和全球 艾滋病毒流行。

PROJECT SUMMARY/ABSTRACT: SEX & GENDER SCIENTIFIC WORKING GROUP 1 There are notable sex- and gender-specific differences in the manifestations of both treated and untreated HIV-1 infection, but it remains to be unequivocally determined whether these are due to intrinsic differences in immunological responses, differential susceptibility to the virus, behavioral modulators, effects due to hormonal differences, or a combination of all these factors. Moreover, although more than 50% of people with HIV are either cis- or transgender women, their under-enrollment in clinical studies has greatly limited our understanding of sex and gender differences in HIV acquisition, mechanisms of immunity and latency, responses to antiretroviral drugs, and behavioral tendencies, such as those driven by the socioeconomic challenges of gender inequity and risk of violence. Addressing these crucial knowledge gaps on sex and gender differences in HIV will facilitate the development of targeted strategies for HIV prevention, treatment, and cure, which are imperative to the goal of globally eradicating HIV infection. The merger of the HIV research communities at CWRU and Pitt in the current application to form the RUSTBELT CFAR has enabled the Sex & Gender SWG1 to assemble an exceptional multidisciplinary team of basic, clinical, translational, and behavioral investigators, each of whom has conducted at least one study on the role of gender or sex in HIV infection or treatment, or have expertise related to the transgender community. Building on the unique strengths of each institution, the Sex & Gender SWG1 will work closely with the RUSTBELT CFAR Cores to achieve the following Specific Aims: (1) To engage CFAR members in research involving sex and gender differences in HIV pathogenesis. (2) To facilitate incorporation of sex and gender differences in treatment, prevention, and cure-related HIV research. (3) To strategically coordinate a formal mentorship program to make junior investigators aware of resources to study Sex & Gender. The success of the Sex & Gender SWG1 will be evaluated based on a well-defined set of key performance metrics. Thus, by taking advantage of the strong HIV prevention, pathogenesis, and cure research that is ongoing within the RUSTBELT CFAR and combining it with our experts in behavioral sciences and public health, the Sex & Gender SWG1 is ideally placed to provide unique insights into the control and management of the national and global HIV epidemics.