The Impact of Metals and Metal Mixtures on Cardiometabolic Disease Trajectories in Hispanics/Latinos

项目摘要/摘要 心脏代谢性疾病(CMD)，包括糖尿病和高血压，影响着世界上三分之二的人 在美国，是全球主要的死亡原因之一。CMDS导致毁灭性后果 对于那些受它们折磨的人，例如增加血管和心脏病的风险，导致未来的致命 并发症，如心肌梗塞或中风。重要的是，这些情况并不影响所有人。 同样如此。CMDS在拉美裔/拉丁裔中更普遍，这一人群患有更严重的并发症和 结果比非西班牙裔白人要多。而生活方式因素和遗传倾向在CMD中起着一定的作用 在发展方面，环境暴露的潜在贡献尚未得到很好的确立。斯塔尔 得克萨斯州的县是一个以墨西哥裔美国人为主的社区，CMD的数量令人震惊，特别是 糖尿病。有趣的是，我们的初步数据表明，金属和类金属暴露可能会增加。 这一人群中CMD和CMD相关特征的风险。因此，我们假设接触到 金属/类金属导致在这一人群中观察到的慢性阻塞性肺疾病风险增加。为了解决这个问题，我们 将利用来自德克萨斯州斯塔尔县的一个成熟的预期队列的数据，斯塔尔县是一个拥有90%人口的社区 西班牙裔/拉丁裔。利用已经测量的尿液金属/类金属浓度，我们将评估 血压、糖化血红蛋白、空腹血浆的纵向心血管和代谢轨迹 葡萄糖，以及评估个人金属暴露和金属混合物的体内平衡措施 3年以上的个人。鉴于慢性精神疾病对个人和社会造成的沉重负担，至关重要的是要确定 可改变的风险因素，以便采取预防、检测和治疗疾病的行动。通过 在这一应用中提出的项目，将获得对金属/类金属暴露的作用的宝贵见解和 生物医学研究中历史上代表性不足的人群中的CMD风险。最后，通过这个建议， 研究项目和培训计划，申请者将获得全面和 来自具有长期合作历史、无数机会的专家团队的互补指导 出版和展示科学进步，以及全面优秀的教育使她能够 成为致力于改善环境健康的独立首席研究员和内科科学家 和健康正义。

Project Summary/Abstract Cardiometabolic diseases (CMDs), including diabetes and hypertension, impact two-thirds of people in the United States and are among the leading causes of death worldwide. CMDs lead to devastating consequences for those afflicated by them, such as the increased risk of vascular and heart disease, leading to future lethal complications such as myocardial infarction or stroke. Importantly, these conditions do not impact all individuals equally. CMDs are more prevalent in Hispanics/Latinos, and this population suffers worse complications and outcomes than non-Hispanic whites. While lifestyle factors and genetic predisposition play a role in CMD development, the potential contributions of environmental exposures has not been well-established. Starr County, Texas, is a predominantly Mexican-American community with staggering rages of CMDs, specifically diabetes mellitus. Interestingly, our preliminary data indicate that metal and metalloid exposures may increase the risk for CMDs and CMD-related traits in this population. Therefore, we hypothesize that exposure to metals/metalloids contributes to the observed heightened risk of CMDs in this population. To address this, we will leverage data from a well-established prospective cohort from Starr County, Texas, a community of >90% Hispanic/Latino origin. Utilizing already measured urinary metal/metalloid concentrations, we will evaluate longitudinal cardiovascular and metabolic trajectories of blood pressure, hemoglobin A1c, fasting plasma glucose, and homostatic measures of assessment for individual metal exposures and metal mixtures in 600 individuals over 3 years. Given the substantial individual and societal burden of CMDs, it is vital to identify modifiable risk factors in order to empower action for disease prevention, detection, and treatment. Through the project proposed in this application, valuable insight will be gained into the role of metal/metalloid exposures and CMD risk in a historically underrepresented population in biomedical research. Lastly, through this proposed research project and training plan, the applicant for this fellowship will receive comprehensive and complementary mentorship from a team of experts with a long history of collaboration, numerous opportunities for publication and presentation of scientific progress, and an overall outstanding education empowering her to become an independent principal investigator and physician-scientist devoted to improving environmental health and health justice.