Cardiometabolic Core
心脏代谢核心
基本信息
- 批准号:10579230
- 负责人:
- 金额:$ 45.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-03-01 至 2027-02-28
- 项目状态:未结题
- 来源:
- 关键词:Animal FeedAnimalsAreaBiological MarkersBlood PressureBody CompositionBody WeightCalendarCardiacCardiometabolic DiseaseCardiovascular DiseasesCardiovascular PhysiologyCardiovascular systemCognitive agingCommunitiesDataData CollectionDedicationsDietDiseaseDisease modelEngineeringEnsureEnzyme-Linked Immunosorbent AssayEquipmentEstrogensExperimental DesignsExtramural ActivitiesFemaleGlucagonGlucose tolerance testGoalsHealthHigh Fat DietHousingHuman ResourcesInsulinMaintenanceMeasurementMetabolicMetabolic DiseasesMetabolic hormoneMonitorMusPhytoestrogensProceduresProtocols documentationRadioimmunoassayRattusRenin-Angiotensin SystemReproducibilityResearchResearch DesignResearch PersonnelResearch Project GrantsReservationsResourcesSamplingScheduleSchoolsScienceServicesStandardizationSystemTissue BanksTissuescardiometabolismexperiencefeedingforestimprovedin vivoinsulin tolerancemedical schoolsmeetingsprogramssample collectionstandardize measuresynergismultrasoundweb site
项目摘要
Cardiometabolic Core (Core B) Summary
The Cardiometabolic Core (Core B) will allow for the careful planning and coordination of research designs,
disease models, and data collection among the four Research Projects. The Core will be utilized for the induction,
maintenance, and analysis of cardiometabolic diseases in rats and mice. Core B will be a newly established
facility housing the equipment and personnel for standardized measures in the proposed Research Projects.
The specific functions of Core B are organized into three Aims. Aim 1 will employ standardized animal diets and
specimen collection across all four projects. It will ensure that feeding, monitoring, and tissue collection are
consistent across projects and will establish a tissue bank available to Tulane and extramural researchers. Aim
2 will employ standardized metabolic measurements across all four projects to provide the same metabolic
conditions and measurements. Aim 3 will employ standardized cardiovascular measurements across all four
projects to ensure that cardiovascular disease is implemented equally in rats and mice. This coordination among
the projects will improve the scope of the research by allowing inferences between studies that could not be
made if each project introduced new variables. In addition, Core B will maintain standardized protocols and
procedures to allow comparison of data across studies and thereby will improve rigor and reproducibility.
心脏代谢核心(核心B)摘要
心脏代谢核心(核心B)将允许仔细规划和协调研究设计,
四个研究项目之间的疾病模型和数据收集。核心将被用于感应,
大鼠和小鼠心脏代谢性疾病的维护和分析。核心B将是一个新成立的
为拟议研究项目中的标准化措施配备设备和人员的设施。
核心B的具体职能分为三个目标。目标1将采用标准化的动物饲料和
在所有四个项目中收集样本。它将确保喂养、监测和组织收集
在各个项目中保持一致,并将建立一个组织库,供杜兰大学和校外研究人员使用。目标
2将在所有四个项目中采用标准化的代谢测量,以提供相同的新陈代谢
条件和测量。AIM 3将在所有四个项目中采用标准化的心血管测量方法
确保心血管疾病在大鼠和小鼠身上平等实施的项目。这一协调在
这些项目将通过允许不能在研究之间进行推断来扩大研究的范围
如果每个项目都引入了新的变量,就会产生影响。此外,核心B将维持标准化的协议和
允许比较不同研究的数据的程序,从而将提高严格性和重复性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Sarah H. Lindsey其他文献
Estrogen-mediated mechanisms in hypertension and other cardiovascular diseases
雌激素介导的高血压和其他心血管疾病的机制
- DOI:
10.1038/s41371-022-00771-0 - 发表时间:
2022-11-01 - 期刊:
- 影响因子:3.400
- 作者:
Bruna Visniauskas;Isabella Kilanowski-Doroh;Benard O. Ogola;Alexandra B. Mcnally;Alec C. Horton;Ariane Imulinde Sugi;Sarah H. Lindsey - 通讯作者:
Sarah H. Lindsey
GPR30 Receptor Activation Improves Cardiac Function in Intact Female mRen2.Lewis Rats
- DOI:
10.1016/j.cardfail.2009.06.173 - 发表时间:
2009-08-01 - 期刊:
- 影响因子:
- 作者:
Jewell A. Jessup;Sarah H. Lindsey;Mark C. Chappell;Leanne Groban - 通讯作者:
Leanne Groban
Ovariectomy-Induced Arterial Stiffening Differs from Vascular Aging and is Reversed by GPER Activation
卵巢切除术引起的动脉硬化与血管老化不同,可通过 GPER 激活来逆转
- DOI:
10.1101/2023.08.10.552881 - 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Isabella M. Kilanowski;Alexandra B McNally;Tristen J. Wong;B. Visniauskas;Sophia A Blessinger;Ariane Imulinde Sugi;Chase Richard;Zaidmara T Diaz;Alec C. Horton;C. Natale;B. Ogola;Sarah H. Lindsey - 通讯作者:
Sarah H. Lindsey
Sarah H. Lindsey的其他文献
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{{ truncateString('Sarah H. Lindsey', 18)}}的其他基金
Impact of estradiol on vascular health and subsequent implications for cognitive aging.
雌二醇对血管健康的影响以及随后对认知衰老的影响。
- 批准号:
10579246 - 财政年份:2022
- 资助金额:
$ 45.03万 - 项目类别:
Impact of estradiol on vascular health and subsequent implications for cognitive aging.
雌二醇对血管健康的影响以及随后对认知衰老的影响。
- 批准号:
10334234 - 财政年份:2022
- 资助金额:
$ 45.03万 - 项目类别:
Eliciting Estrogen's Protective Vascular Effects
激发雌激素的保护性血管作用
- 批准号:
9474239 - 财政年份:2017
- 资助金额:
$ 45.03万 - 项目类别:
Eliciting Estrogen's Protective Vascular Effects
激发雌激素的保护性血管作用
- 批准号:
9318676 - 财政年份:2017
- 资助金额:
$ 45.03万 - 项目类别:
Vascular Interactions of Estrogen Receptor GPR30 and the Renin-Angiotensin System
雌激素受体 GPR30 和肾素-血管紧张素系统的血管相互作用
- 批准号:
8661246 - 财政年份:2011
- 资助金额:
$ 45.03万 - 项目类别:
Vascular Interactions of Estrogen Receptor GPR30 and the Renin-Angiotensin System
雌激素受体 GPR30 和肾素-血管紧张素系统的血管相互作用
- 批准号:
8529601 - 财政年份:2011
- 资助金额:
$ 45.03万 - 项目类别:
Vascular Interactions of Estrogen Receptor GPR30 and the Renin-Angiotensin System
雌激素受体 GPR30 和肾素-血管紧张素系统的血管相互作用
- 批准号:
8111440 - 财政年份:2011
- 资助金额:
$ 45.03万 - 项目类别:
Vascular Interactions of Estrogen Receptor GPR30 and the Renin-Angiotensin System
雌激素受体 GPR30 和肾素-血管紧张素系统的血管相互作用
- 批准号:
8431498 - 财政年份:2011
- 资助金额:
$ 45.03万 - 项目类别:
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