Cardiometabolic Core

心脏代谢核心

• 批准号: 10579230
• 负责人: Sarah H. Lindsey
• 金额: $ 45.03万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10579230
• 关键词: Animal Feed; Animals; Area; Biological Markers; Blood Pressure; Body Composition; Body Weight; Calendar; Cardiac; Cardiometabolic Disease; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Cognitive aging; Communities; Data; Data Collection; Dedications; Diet; Disease; Disease model; Engineering; Ensure; Enzyme-Linked Immunosorbent Assay; Equipment; Estrogens; Experimental Designs; Extramural Activities; Female; Glucagon; Glucose tolerance test; Goals; Health; High Fat Diet; Housing; Human Resources; Insulin; Maintenance; Measurement; Metabolic; Metabolic Diseases; Metabolic hormone; Monitor; Mus; Phytoestrogens; Procedures; Protocols documentation; Radioimmunoassay; Rattus; Renin-Angiotensin System; Reproducibility; Research; Research Design; Research Personnel; Research Project Grants; Reservations; Resources; Sampling; Schedule; Schools; Science; Services; Standardization; System; Tissue Banks; Tissues; cardiometabolism; experience; feeding; forest; improved; in vivo; insulin tolerance; medical schools; meetings; programs; sample collection; standardize measure; synergism; ultrasound; web site

Cardiometabolic Core (Core B) Summary The Cardiometabolic Core (Core B) will allow for the careful planning and coordination of research designs, disease models, and data collection among the four Research Projects. The Core will be utilized for the induction, maintenance, and analysis of cardiometabolic diseases in rats and mice. Core B will be a newly established facility housing the equipment and personnel for standardized measures in the proposed Research Projects. The specific functions of Core B are organized into three Aims. Aim 1 will employ standardized animal diets and specimen collection across all four projects. It will ensure that feeding, monitoring, and tissue collection are consistent across projects and will establish a tissue bank available to Tulane and extramural researchers. Aim 2 will employ standardized metabolic measurements across all four projects to provide the same metabolic conditions and measurements. Aim 3 will employ standardized cardiovascular measurements across all four projects to ensure that cardiovascular disease is implemented equally in rats and mice. This coordination among the projects will improve the scope of the research by allowing inferences between studies that could not be made if each project introduced new variables. In addition, Core B will maintain standardized protocols and procedures to allow comparison of data across studies and thereby will improve rigor and reproducibility.

心脏代谢核心(核心B)摘要 心脏代谢核心(核心B)将允许仔细规划和协调研究设计， 四个研究项目之间的疾病模型和数据收集。核心将被用于感应， 大鼠和小鼠心脏代谢性疾病的维护和分析。核心B将是一个新成立的 为拟议研究项目中的标准化措施配备设备和人员的设施。 核心B的具体职能分为三个目标。目标1将采用标准化的动物饲料和 在所有四个项目中收集样本。它将确保喂养、监测和组织收集 在各个项目中保持一致，并将建立一个组织库，供杜兰大学和校外研究人员使用。目标 2将在所有四个项目中采用标准化的代谢测量，以提供相同的新陈代谢 条件和测量。AIM 3将在所有四个项目中采用标准化的心血管测量方法 确保心血管疾病在大鼠和小鼠身上平等实施的项目。这一协调在 这些项目将通过允许不能在研究之间进行推断来扩大研究的范围 如果每个项目都引入了新的变量，就会产生影响。此外，核心B将维持标准化的协议和 允许比较不同研究的数据的程序，从而将提高严格性和重复性。