Career Enhancement Core

摘要 我们建议成立一个联盟，研究艾滋病毒相关癌症的表观基因组生物标记物 尼日利亚。“我们的研究重点和核心服务发展计划已经被我们的尼日利亚人优先考虑 乔斯大学(UniJos)的合作伙伴，位于尼日利亚中部的高原州立大学 拉各斯(UNILAG)，拉各斯州，人口稠密的西南部。我们对艾滋病毒表观遗传学的关注-- 我们广泛的合作证明了相关的肝细胞癌和宫颈癌是合理的 病毒疾病的研究历史，包括艾滋病毒、人乳头瘤病毒、乙肝和丙型肝炎病毒。 西北大学和梅奥医学院将作为美国高收入合作机构 与尼日利亚的研究和研究培训合作的悠久历史证明了这一点 这些机构与其在全球卫生方面的专业知识和充足的补充资源相结合。一位少校 我们提案的组成部分是加强尼日利亚科学家的职业生涯，包括初级调查人员和 扩大尼日利亚联合体机构的整体科学能力。职业提升的核心 (CEC)将支持与研究相关的活动，以促进和促进 尼日利亚调查人员。CEC的目标是：1.为低年级学生开展辅导研究活动 UniJos和UNILAG的调查人员将加强他们未来的研究领导能力，2.建立一个 该计划将支持由UniJos和UniJos的初级调查人员领导的有指导的研究试点研究 UNILAG专注于艾滋病毒相关癌症的表观遗传生物标记物，包括但不限于 在本提案的项目1和2中学习，以及3.提高研究核心能力、技术技能和 UniJos和UNILAG调查员的领导和管理能力，以确保成功的独立 为初级研究人员提供研究经费，以支持未来的研究。所有有指导的研究活动都将 与美国和尼日利亚的导师共同开发的。这些活动将以活动为重点。 围绕项目1(肝细胞癌)和项目2(颈部)的实施。在CEC下支持的试点项目将包括 与现有项目1和2有关，或可能涉及不同的癌症或生物标记物。试点项目将有 申请者资格、申请流程、项目选择、 评估、对人类受试者的保护、法规要求和道德委员会批准。CEC 培训活动将包括特定科学和技术技能的说明式和体验式培训 可在家庭机构(如DNA甲基化实验室技术)、正规教学和 核心研究能力的经验式培训，包括生物统计和研究分析、研究 方法论、伦理学、团队科学、项目领导/管理技能、手稿撰写、拨款撰写、 和科学的展示。

Abstract We propose to establish a Consortium to study “Epigenomic Biomarkers of HIV-Associated Cancers in Nigeria.” Our research focus and core services development plan has been prioritized by our Nigerian partners at University of Jos (UniJos), Plateau State, Nigeria located in the center of the country and University of Lagos (UniLag), Lagos State in the densely populated southwest. Our focus on the epigenetics of HIV- associated hepatocellular carcinoma (HCC) and cervical cancer is justified by our extensive collaborative research history in viral diseases including HIV, human papilloma virus, hepatitis B and C viruses. Northwestern University and Mayo Medical School will serve as the high-income American partner institutions which is justified by the long history of research and research training collaboration with the Nigerian institutions coupled with its expertise in global health and ample complementary resources. A major component of our proposal is to enhance the careers of Nigerian scientists including junior investigators and expand the overall scientific capacity at the Nigerian consortium institutions. The Career Enhancement Core (CEC) will support research-related activities that will facilitate and enhance the professional development of Nigerian investigators. The aims of the CEC are to: 1. develop mentored research activities for junior investigators at UniJos and UniLag that will enhance their future research leadership capabilities, 2. establish a program which will support mentored research pilot studies to be led by junior investigators at UniJos and UniLag focused on epigenetic biomarkers of HIV-associated cancers, including by not limited to the ones being studied in Projects 1 and 2 of this proposal, and 3. enhance research core competencies, technical skills, and leadership and management capabilities of UniJos and UniLag investigators to assure successful independent research funding of junior investigators to sustain future research. All mentored research activities will be developed jointly with American and Nigerian mentors. These activities will be focused on activities surrounding the conduct of Projects 1 (HCC) and 2 (cervical). Pilot projects supported under the CEC will be related to the existing Projects 1 and 2 or may involve different cancers or biomarkers. Pilot projects will have specific requirements and procedures for applicant eligibility, application process, selection of projects, evaluation, protection of human subjects, regulatory requirements, and ethics committee approval. CEC training activities will include both didactic and experiential training in specific scientific and technical skills not available in the home institutions (such as DNA methylation laboratory techniques), formal didactic and experiential training in core research competencies including biostatistics and research analytics, research methodologies, ethics, team science, project leadership/management skills, manuscript writing, grant writing, and scientific presentation.