Career Enhancement Core

职业提升核心

• 批准号: 10242894
• 负责人: ROBERT Leo MURPHY
• 金额: $ 10.86万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10242894
• 关键词: AIDS related cancer; Address; American; Americas; Biological Markers; Biometry; Cervical; Collaborations; Competence; Country; Coupled; DNA Methylation; Development; Development Plans; Eligibility Determination; Epigenetic Process; Ethics; Ethics Committees; Evaluation; Funding; Genomics; Grant; HIV; Hepatitis B; Hepatitis C virus; Home; Human Papillomavirus; Income; Individual; Infection; Institution; Laboratories; Leadership; Link; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Manuscripts; Mentors; Molecular Epidemiology; Nigeria; Nigerian; Northwestern United States; Pathology; Peer Review; Pilot Projects; Primary carcinoma of the liver cells; Procedures; Process; Recording of previous events; Research; Research Activity; Research Design; Research Methodology; Research Personnel; Research Support; Research Training; Resources; Science; Scientist; Services; Teaching Hospitals; Technical Expertise; Techniques; Training; Training Activity; Training Programs; Universities; Virus Diseases; Work; Writing; biomedical informatics; career; epidemiology study; epigenetic marker; epigenomics; experience; global health; human subject protection; low and middle-income countries; medical schools; member; programs; response; skills; statistics; synergism

Abstract We propose to establish a Consortium to study “Epigenomic Biomarkers of HIV-Associated Cancers in Nigeria.” Our research focus and core services development plan has been prioritized by our Nigerian partners at University of Jos (UniJos), Plateau State, Nigeria located in the center of the country and University of Lagos (UniLag), Lagos State in the densely populated southwest. Our focus on the epigenetics of HIV- associated hepatocellular carcinoma (HCC) and cervical cancer is justified by our extensive collaborative research history in viral diseases including HIV, human papilloma virus, hepatitis B and C viruses. Northwestern University and Mayo Medical School will serve as the high-income American partner institutions which is justified by the long history of research and research training collaboration with the Nigerian institutions coupled with its expertise in global health and ample complementary resources. A major component of our proposal is to enhance the careers of Nigerian scientists including junior investigators and expand the overall scientific capacity at the Nigerian consortium institutions. The Career Enhancement Core (CEC) will support research-related activities that will facilitate and enhance the professional development of Nigerian investigators. The aims of the CEC are to: 1. develop mentored research activities for junior investigators at UniJos and UniLag that will enhance their future research leadership capabilities, 2. establish a program which will support mentored research pilot studies to be led by junior investigators at UniJos and UniLag focused on epigenetic biomarkers of HIV-associated cancers, including by not limited to the ones being studied in Projects 1 and 2 of this proposal, and 3. enhance research core competencies, technical skills, and leadership and management capabilities of UniJos and UniLag investigators to assure successful independent research funding of junior investigators to sustain future research. All mentored research activities will be developed jointly with American and Nigerian mentors. These activities will be focused on activities surrounding the conduct of Projects 1 (HCC) and 2 (cervical). Pilot projects supported under the CEC will be related to the existing Projects 1 and 2 or may involve different cancers or biomarkers. Pilot projects will have specific requirements and procedures for applicant eligibility, application process, selection of projects, evaluation, protection of human subjects, regulatory requirements, and ethics committee approval. CEC training activities will include both didactic and experiential training in specific scientific and technical skills not available in the home institutions (such as DNA methylation laboratory techniques), formal didactic and experiential training in core research competencies including biostatistics and research analytics, research methodologies, ethics, team science, project leadership/management skills, manuscript writing, grant writing, and scientific presentation.

抽象的 我们建议建立一个联盟来研究“艾滋病毒相关癌症的表观基因组生物标志物” 尼日利亚。”我们的研究重点和核心服务发展计划已被我们的尼日利亚优先考虑 尼日利亚高原州乔斯大学 (UniJos) 的合作伙伴位于该国中部 拉各斯（UniLag），拉各斯州位于人口稠密的西南部。我们专注于艾滋病毒的表观遗传学- 我们广泛的合作证明了相关肝细胞癌 (HCC) 和宫颈癌的合理性 病毒性疾病的研究历史，包括艾滋病毒、人乳头瘤病毒、乙型和丙型肝炎病毒。 西北大学和梅奥医学院将作为美国高收入合作院校 与尼日利亚的研究和研究培训合作的悠久历史证明了这一点 机构及其在全球卫生方面的专业知识和充足的补充资源。一个专业 我们提案的一部分是提高尼日利亚科学家的职业生涯，包括初级研究人员和 扩大尼日利亚联盟机构的整体科学能力。职业提升核心 （CEC）将支持与研究相关的活动，以促进和加强专业发展 尼日利亚调查人员。 CEC 的目标是： 1. 为初级学生开展指导性研究活动 UniJos 和 UniLag 的研究人员将增强他们未来的研究领导能力， 2. 建立一个 该计划将支持由 UniJos 的初级研究人员领导的指导性研究试点研究 UniLag 专注于 HIV 相关癌症的表观遗传生物标志物，包括但不限于 在本提案的项目 1 和 2 中进行研究，以及 3. 增强研究核心能力、技术技能和 UniJos 和 UniLag 调查人员的领导和管理能力，以确保成功的独立 为初级研究人员提供研究经费以维持未来的研究。所有指导的研究活动都将 与美国和尼日利亚导师共同开发。这些活动将集中于活动 围绕项目 1（HCC）和 2（宫颈）的实施。 CEC 支持的试点项目将 与现有项目 1 和 2 相关或可能涉及不同的癌症或生物标志物。试点项目将有 申请人资格、申请流程、项目选择的具体要求和程序， 评估、人类受试者保护、监管要求和伦理委员会批准。中电公司 培训活动将包括具体科学和技术技能的教学和体验培训，而不是 可在国内机构获得（例如 DNA 甲基化实验室技术）、正式的教学和 核心研究能力的体验式培训，包括生物统计学和研究分析、研究 方法论、道德、团队科学、项目领导/管理技能、手稿写作、资助写作、 和科学的呈现。