“Phenotyping Heart Failure with Preserved Ejection Fraction Using Non- Invasive Biomarkers
使用非侵入性生物标志物通过保留射血分数对心力衰竭进行表型分析
基本信息
- 批准号:10624557
- 负责人:
- 金额:$ 19.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-01 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressBiological MarkersBiologyBlood VesselsCardiopulmonaryCenters of Research ExcellenceClinical assessmentsDiffusion Magnetic Resonance ImagingEFRACExercise ToleranceFailureFiberHeart failureImaging TechniquesImpairmentKnowledgeMagnetic Resonance SpectroscopyMedicalMorbidity - disease rateMyocardialPatientsPhenotypeQuality of lifecardiac magnetic resonance imagingcirculating biomarkerseffective therapyfunctional disabilityheart functionimaging biomarkermortalitynovelpreservation
项目摘要
Heart failure with preserved ejection fraction (HFpEF) is highly prevalent and associated with impaired functional tolerance, quality of life, morbidity and mortality. Although medical advances have led to effective treatments for heart failure with reduced ejection fraction, there are very limited treatment options for treating HFpEF. While contemporary clinical assessment provides some information beyond ejection fraction in assessment of cardiac function in patients with HFpEF, there is a need to identify biomarkers that associate with pathophysiologic mechanisms of impaired cardiac function. Therefore, we propose to address this knowledge gap by identifying imaging and circulating biomarkers with pathophysiological mechanisms that are associated with exercise tolerance and quality of life in patients with HFpEF. Our
specific aim is two-fold: 1) to examine the association of imaging biomarkers of myocardial fiber orientation
with exercise tolerance and quality of life and circulating biomarkers in patients with HFpEF, and 2) to examine the association of imaging biomarkers of myocardial energetics with exercise tolerance and quality of life and circulating biomarkers in patients with HFpEF. We will analyze myocardial fiber orientation using a novel diffusion tensor imaging technique in cardiac MRI and myocardial energetics using 31-P magnetic resonance spectroscopy.
保留射血分数(HFpEF)心力衰竭非常普遍,并与功能耐受性受损、生活质量、发病率和死亡率相关。虽然医学的进步已经导致了有效的治疗心力衰竭和降低射血分数,但治疗HFpEF的治疗方案非常有限。虽然目前的临床评估提供了一些除射血分数以外的信息来评估HFpEF患者的心功能,但仍需要确定与心功能受损病理生理机制相关的生物标志物。因此,我们建议通过识别与HFpEF患者运动耐量和生活质量相关的病理生理机制的成像和循环生物标志物来解决这一知识缺口。我们的
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Elizabeth O Harrington其他文献
Elizabeth O Harrington的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Elizabeth O Harrington', 18)}}的其他基金
Uncoupling of IL-1 beta and VEGF-A Crosstalk Contributes to Impaired Arteriogenesis Response to Ischemia in Chronic Diabetes Mellitus
IL-1β 和 VEGF-A 串扰的解偶联导致慢性糖尿病缺血的动脉生成反应受损
- 批准号:
10549633 - 财政年份:2021
- 资助金额:
$ 19.13万 - 项目类别:
The Role of NPR-C In Modulation Of Acute Lung Injury
NPR-C 在调节急性肺损伤中的作用
- 批准号:
9235305 - 财政年份:2015
- 资助金额:
$ 19.13万 - 项目类别:
Uncoupling of IL-1 beta and VEGF-A Crosstalk Contributes to Impaired Arteriogenesis Response to Ischemia in Chronic Diabetes Mellitus
IL-1β 和 VEGF-A 串扰的解偶联导致慢性糖尿病缺血的动脉生成反应受损
- 批准号:
10579818 - 财政年份:2013
- 资助金额:
$ 19.13万 - 项目类别:
相似海外基金
MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers
吸烟者和电子烟使用者急性电子烟暴露的 MRI 和生物标志物
- 批准号:
10490338 - 财政年份:2021
- 资助金额:
$ 19.13万 - 项目类别:
MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers
吸烟者和电子烟使用者急性电子烟暴露的 MRI 和生物标志物
- 批准号:
10353104 - 财政年份:2021
- 资助金额:
$ 19.13万 - 项目类别:
Investigating pollution dynamics of swimming pool waters by means of chemical and biological markers
利用化学和生物标记物研究游泳池水体的污染动态
- 批准号:
21K04320 - 财政年份:2021
- 资助金额:
$ 19.13万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers
吸烟者和电子烟使用者急性电子烟暴露的 MRI 和生物标志物
- 批准号:
10688286 - 财政年份:2021
- 资助金额:
$ 19.13万 - 项目类别:
Novel biological markers for immunotherapy and comprehensive genetic analysis in thymic carcinoma
用于胸腺癌免疫治疗和综合遗传分析的新型生物标志物
- 批准号:
20K17755 - 财政年份:2020
- 资助金额:
$ 19.13万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Examination of Biological Markers Associated with Neurobehavioral and Neuropsychological Outcomes in Military Veterans with a History of Traumatic Brain Injury
与有脑外伤史的退伍军人的神经行为和神经心理结果相关的生物标志物的检查
- 批准号:
10578649 - 财政年份:2019
- 资助金额:
$ 19.13万 - 项目类别:
Examination of Biological Markers Associated with Neurobehavioral and Neuropsychological Outcomes in Military Veterans with a History of Traumatic Brain Injury
与有脑外伤史的退伍军人的神经行为和神经心理结果相关的生物标志物的检查
- 批准号:
10295141 - 财政年份:2019
- 资助金额:
$ 19.13万 - 项目类别:
Examination of Biological Markers Associated with Neurobehavioral and Neuropsychological Outcomes in Military Veterans with a History of Traumatic Brain Injury
与有脑外伤史的退伍军人的神经行为和神经心理结果相关的生物标志物的检查
- 批准号:
10041708 - 财政年份:2019
- 资助金额:
$ 19.13万 - 项目类别:
Examination of Biological Markers Associated with Neurobehavioral and Neuropsychological Outcomes in Military Veterans with a History of Traumatic Brain Injury
与有脑外伤史的退伍军人的神经行为和神经心理结果相关的生物标志物的检查
- 批准号:
9776149 - 财政年份:2019
- 资助金额:
$ 19.13万 - 项目类别:
Combining biological and non-biological markers to develop a model predictive of treatment response for individuals with depression
结合生物和非生物标志物来开发预测抑郁症患者治疗反应的模型
- 批准号:
2063934 - 财政年份:2018
- 资助金额:
$ 19.13万 - 项目类别:
Studentship














{{item.name}}会员




