“Phenotyping Heart Failure with Preserved Ejection Fraction Using Non- Invasive Biomarkers

使用非侵入性生物标志物通过保留射血分数对心力衰竭进行表型分析

• 批准号: 10624557
• 负责人: Elizabeth O Harrington
• 金额: $ 19.13万
• 依托单位: OCEAN STATE RESEARCH INSTITUTE, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10624557
• 关键词: Address; Biological Markers; Biology; Blood Vessels; Cardiopulmonary; Centers of Research Excellence; Clinical assessments; Diffusion Magnetic Resonance Imaging; EFRAC; Exercise Tolerance; Failure; Fiber; Heart failure; Imaging Techniques; Impairment; Knowledge; Magnetic Resonance Spectroscopy; Medical; Morbidity - disease rate; Myocardial; Patients; Phenotype; Quality of life; cardiac magnetic resonance imaging; circulating biomarkers; effective therapy; functional disability; heart function; imaging biomarker; mortality; novel; preservation

Heart failure with preserved ejection fraction (HFpEF) is highly prevalent and associated with impaired functional tolerance, quality of life, morbidity and mortality. Although medical advances have led to effective treatments for heart failure with reduced ejection fraction, there are very limited treatment options for treating HFpEF. While contemporary clinical assessment provides some information beyond ejection fraction in assessment of cardiac function in patients with HFpEF, there is a need to identify biomarkers that associate with pathophysiologic mechanisms of impaired cardiac function. Therefore, we propose to address this knowledge gap by identifying imaging and circulating biomarkers with pathophysiological mechanisms that are associated with exercise tolerance and quality of life in patients with HFpEF. Our specific aim is two-fold: 1) to examine the association of imaging biomarkers of myocardial fiber orientation with exercise tolerance and quality of life and circulating biomarkers in patients with HFpEF, and 2) to examine the association of imaging biomarkers of myocardial energetics with exercise tolerance and quality of life and circulating biomarkers in patients with HFpEF. We will analyze myocardial fiber orientation using a novel diffusion tensor imaging technique in cardiac MRI and myocardial energetics using 31-P magnetic resonance spectroscopy.

射血分数保留的心力衰竭（HFpEF）非常普遍，并与功能耐受力受损、生活质量、发病率和死亡率相关。尽管医学进步已经导致射血分数降低的心力衰竭的有效治疗，但治疗 HFpEF 的治疗选择非常有限。虽然当代临床评估在评估 HFpEF 患者的心功能时提供了射血分数以外的一些信息，但仍需要确定与心功能受损的病理生理机制相关的生物标志物。因此，我们建议通过识别与 HFpEF 患者运动耐量和生活质量相关的病理生理机制的成像和循环生物标志物来解决这一知识差距。我们的 具体目标有两个：1）检查心肌纤维取向的成像生物标志物的关联 2) 检查心肌能量成像生物标志物与 HFpEF 患者的运动耐量、生活质量和循环生物标志物的关系。我们将在心脏 MRI 中使用新型扩散张量成像技术分析心肌纤维取向，并使用 31-P 磁共振波谱分析心肌能量学。