Mentoring a Nigerian junior investigator with a mixed-methods analysis of barriers to colorectal cancer presentation in Nigeria

指导一名尼日利亚初级研究员对尼日利亚结直肠癌表现的障碍进行混合方法分析

• 批准号: 10623852
• 负责人: OLUSEGUN ISAAC ALATISE
• 金额: $ 12.5万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10623852
• 关键词: Administrative Supplement; Africa; Africa South of the Sahara; Age-Years; Award; Cancer Intervention; Case-Control Studies; Colorectal Cancer; Communities; Complement; Country; Data; Diagnosis; Dietary History; Early Diagnosis; Focus Groups; Funding; Future; Goals; Incidence; Intervention; Interview; Knowledge; Life Style; Malignant Neoplasms; Medical History; Mentors; Mentorship; Methods; Nigeria; Nigerian; Outcome; Parents; Participant; Patients; Persons; Phase; Population; Prevention; Questionnaires; Research; Research Personnel; Resource-limited setting; Risk Factors; Scientist; Subgroup; Surgeon; Symptoms; Work; base; cancer diagnosis; colorectal cancer risk; early onset colorectal cancer; high risk; improved; interest; mortality; population based; recruit; reproductive; response; screening; statistics; symptom treatment

SUMMARY/ABSTRACT This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 22-036. This is an administrative supplement to our parent award R01 CA246620 (PI: Alatise/Du/Kingham) focused on identifying risk factors for colorectal cancer (CRC) in Nigeria. Our work is motivated by the rapidly rising incidence and mortality of CRC in sub-Saharan Africa. This increasing burden is mirrored in Nigeria, the most populous country in Africa, where >50% of patients die within one year of diagnosis. These statistics highlight the need for new prevention, screening, and treatment interventions tailored to this limited-resource region. However, traditional risk factors that serve as a basis for CRC interventions are far less common in Nigeria compared to Western populations. To better understand the unique risk factors of CRC, we are recruiting 600 CRC cases and 1,200 matched cancer-free population-based controls for a case-control study as part of our ongoing parent R01. Participants complete a questionnaire to assess demographic, anthropometric, reproductive, lifestyle, dietary, and medical history. We expect to obtain knowledge of CRC risk factors to identify high-risk subgroups that can be targeted for screening and/or early detection. In addition, through this work, we have built research capacity to facilitate complementary CRC studies. As such, the overarching goals for this supplement are to strengthen capacity for high-quality research through mentorship of a promising junior surgeon-scientist, and to generate evidence that will complement our R01 findings. Specifically in this supplemental project, we will conduct a mixed-methods study to determine knowledge of CRC and barriers to CRC early diagnosis in patients in Lagos, Nigeria. Patients ≥50 years of age (n=350) who are healthy controls in our R01-funded case-control study will participate in quantitative assessment of knowledge of CRC symptoms and treatments. For the qualitative phase, community-based focus groups in people without CRC and in-depth one-on-one interviews with patients with CRC will be conducted. The study's key outcomes are knowledge of CRC symptoms, CRC diagnosis practices, and barriers to CRC early diagnosis. We expect this supplemental project to generate rich data that paired with our R01 findings can guide future improvements in CRC diagnosis in Nigeria to ultimately improve treatment options and outcomes.

摘要/摘要 本申请是为了响应被识别为 NOT-CA- 的特殊利益通知 (NOSI) 而提交的 22-036。这是对我们家长奖 R01 CA246620 的行政补充（PI：Alatise/Du/Kingham） 重点是确定尼日利亚结直肠癌 (CRC) 的危险因素。我们的工作动力来自于快速发展 撒哈拉以南非洲地区结直肠癌的发病率和死亡率不断上升。这种日益增加的负担也反映在尼日利亚 非洲人口最多的国家，超过 50% 的患者在诊断后一年内死亡。这些统计数据 强调需要针对这种有限的资源采取新的预防、筛查和治疗干预措施 地区。然而，作为结直肠癌干预措施基础的传统风险因素在 尼日利亚与西方人口相比。为了更好地了解 CRC 的独特风险因素，我们正在招募 作为病例对照研究的一部分，600 例 CRC 病例和 1,200 例相匹配的无癌症人群对照 我们的母公司 R01。参与者填写一份调查问卷来评估人口统计、人体测量、 生殖、生活方式、饮食和病史。我们希望获得 CRC 风险因素的知识来识别 可作为筛查和/或早期检测目标的高风险亚组。此外，通过这项工作，我们 已建立研究能力以促进补充性 CRC 研究。因此，本次活动的总体目标 补充是通过指导有前途的初级人员来加强高质量研究的能力 外科医生科学家，并产生证据来补充我们的 R01 研究结果。具体在这方面 补充项目中，我们将进行一项混合方法研究，以确定 CRC 知识和障碍 尼日利亚拉各斯患者的结直肠癌早期诊断。年龄≥50岁的健康对照患者（n=350） 在我们的 R01 资助的病例对照研究中，我们将参与对 CRC 症状知识的定量评估 和治疗。在定性阶段，对没有 CRC 的人群进行基于社区的焦点小组深入研究 将对 CRC 患者进行一对一访谈。该研究的主要成果是了解 CRC 症状、CRC 诊断实践以及 CRC 早期诊断的障碍。我们期待这个补充 生成丰富数据的项目，与我们的 R01 研究结果相结合，可以指导 CRC 诊断的未来改进 在尼日利亚，最终改善治疗选择和结果。