Mentoring a Nigerian junior investigator with a mixed-methods analysis of barriers to colorectal cancer presentation in Nigeria

指导一名尼日利亚初级研究员对尼日利亚结直肠癌表现的障碍进行混合方法分析

• 批准号: 10623852
• 负责人: OLUSEGUN ISAAC ALATISE
• 金额: $ 12.5万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10623852
• 关键词: Administrative Supplement; Africa; Africa South of the Sahara; Age-Years; Award; Cancer Intervention; Case-Control Studies; Colorectal Cancer; Communities; Complement; Country; Data; Diagnosis; Dietary History; Early Diagnosis; Focus Groups; Funding; Future; Goals; Incidence; Intervention; Interview; Knowledge; Life Style; Malignant Neoplasms; Medical History; Mentors; Mentorship; Methods; Nigeria; Nigerian; Outcome; Parents; Participant; Patients; Persons; Phase; Population; Prevention; Questionnaires; Research; Research Personnel; Resource-limited setting; Risk Factors; Scientist; Subgroup; Surgeon; Symptoms; Work; base; cancer diagnosis; colorectal cancer risk; early onset colorectal cancer; high risk; improved; interest; mortality; population based; recruit; reproductive; response; screening; statistics; symptom treatment

SUMMARY/ABSTRACT This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 22-036. This is an administrative supplement to our parent award R01 CA246620 (PI: Alatise/Du/Kingham) focused on identifying risk factors for colorectal cancer (CRC) in Nigeria. Our work is motivated by the rapidly rising incidence and mortality of CRC in sub-Saharan Africa. This increasing burden is mirrored in Nigeria, the most populous country in Africa, where >50% of patients die within one year of diagnosis. These statistics highlight the need for new prevention, screening, and treatment interventions tailored to this limited-resource region. However, traditional risk factors that serve as a basis for CRC interventions are far less common in Nigeria compared to Western populations. To better understand the unique risk factors of CRC, we are recruiting 600 CRC cases and 1,200 matched cancer-free population-based controls for a case-control study as part of our ongoing parent R01. Participants complete a questionnaire to assess demographic, anthropometric, reproductive, lifestyle, dietary, and medical history. We expect to obtain knowledge of CRC risk factors to identify high-risk subgroups that can be targeted for screening and/or early detection. In addition, through this work, we have built research capacity to facilitate complementary CRC studies. As such, the overarching goals for this supplement are to strengthen capacity for high-quality research through mentorship of a promising junior surgeon-scientist, and to generate evidence that will complement our R01 findings. Specifically in this supplemental project, we will conduct a mixed-methods study to determine knowledge of CRC and barriers to CRC early diagnosis in patients in Lagos, Nigeria. Patients ≥50 years of age (n=350) who are healthy controls in our R01-funded case-control study will participate in quantitative assessment of knowledge of CRC symptoms and treatments. For the qualitative phase, community-based focus groups in people without CRC and in-depth one-on-one interviews with patients with CRC will be conducted. The study's key outcomes are knowledge of CRC symptoms, CRC diagnosis practices, and barriers to CRC early diagnosis. We expect this supplemental project to generate rich data that paired with our R01 findings can guide future improvements in CRC diagnosis in Nigeria to ultimately improve treatment options and outcomes.

摘要/摘要 本申请是为了回应被确认为非CA-CA的特殊利益通知(NOSI)而提交的 22-036。这是我们的父级奖项R01 CA246620(PI：Alatise/Du/Kingham)的行政补充 重点是确定尼日利亚结直肠癌(CRC)的风险因素。我们的工作是由快速的 撒哈拉以南非洲地区结直肠癌发病率和死亡率上升。这种日益沉重的负担反映在尼日利亚， 非洲人口最多的国家，50%的患者在确诊后一年内死亡。这些统计数据 强调需要为这一有限资源量身定做新的预防、筛查和治疗干预措施 区域。然而，作为CRC干预基础的传统风险因素在 尼日利亚与西方人口相比。为了更好地了解结直肠癌的独特风险因素，我们招募了 600例结直肠癌病例和1,200例匹配的基于非癌症人群的对照研究作为 我们的继父R01。参与者完成一份调查问卷，以评估人口统计、人体测量、 生殖、生活方式、饮食和医学史。我们希望获得有关CRC风险因素的知识，以确定 可作为筛查和/或早期检测目标的高危亚群。此外，通过这项工作，我们 建立了研究能力，以促进《儿童权利公约》的补充研究。因此，这一行动的首要目标是 补充是通过指导一个有前途的小学生来加强高质量研究的能力 外科医生-科学家，并产生证据，以补充我们的R01发现。特别是在这一点上 补充项目，我们将进行一项混合方法研究，以确定儿童权利公约的知识和障碍 尼日利亚拉各斯患者的早期结直肠癌诊断。≥50岁健康对照患者(n=350) 在我们的R01资助的病例对照研究中，将参与对结直肠癌症状知识的定量评估 和治疗。对于定性阶段，以社区为基础的焦点小组在没有儿童权利和深入的人群中 将与结直肠癌患者进行一对一的面谈。这项研究的主要结果是了解 结直肠癌症状、结直肠癌诊断实践、结直肠癌早期诊断障碍。我们希望这份补充材料 生成丰富数据的项目与我们的R01发现相匹配，可以指导未来对结直肠癌诊断的改进 在尼日利亚，以最终改善治疗选择和结果。