ACTIV Integration of Host-targeting Therapies for COVID-19 Administrative Coordinating Center
ACTIV 针对 COVID-19 的宿主靶向治疗整合行政协调中心
基本信息
- 批准号:10621062
- 负责人:
- 金额:$ 17149.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-06-15 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
RTI International is pleased to provide this application as requested by the Research Opportunities
Announcement OTA-20-011 ACTIV Integration of Host-targeting Therapies for COVID-19 for the role
of Administrative Coordinating Center (ACC). The title of our application is ACTIV Integration of
Host-targeting Therapies for COVID-19 Administrative Coordinating Center.
The Integration of Host-targeting Therapies for COVID-19 Program aims to identify COVID-19
interventions relevant to heart, lung, blood, and cardiovascular outcomes that contribute to the scientific
knowledge base are likely to inform clinical practice. This Program will rapidly and efficiently conduct
adaptive platform trials via a coordinated effort of Data Coordinating Centers and clinical sites from
existing Clinical Study Networks. The ACC is a critical component of the Program. We will coordinate
with NHLBI to ensure collaboration among networks including the use of standardized approaches in
clinical trial design and conduct, data collection and validation, and statistical analysis such that studies
are launched, implemented and analyzed swiftly; and study findings are scientifically sound and meet
regulatory needs for medical therapy development. As the ACC, we will also serve the vital role of
facilitating communication and information sharing among all relevant stake holders and helping NHLBI
in tracking study-specific and Program-wide milestones.
Sonia Thomas, DrPH, will lead the ACC as Principal Investigator. She is an experienced CC PI and
statistician with 25 years of experience in the design, implementation, and analysis of multicenter NIHand
industry-sponsored Phase 2-4 clinical trials of drugs, biologics, devices, surgical and behavioral
interventions in more than a dozen therapeutic indications. Dr. Thomas will be supported by Tracy
Nolen, DrPH as Alternate PI, an experienced Consortium and CC PI and clinical trial statistician, and
subject matter experts Steve Nissen, MD, Cleveland Clinical Chief Academic Officer, Heart and
Vascular Institute, Shannon Carson, MD, Univ. of North Carolina Chief of Pulmonary and Critical Care
Medicine, and Anastasia Ivanova, PhD, Univ. of North Carolina Professor of Biostatistics
Under Dr Thomas’s direction, our team will lead, support, and collaborate with Program Networks
through organization into 6 ACC Cores: Program Operations, Scientific Leadership and
Prioritization, Informatics, Data Standards, Study Design, Implementation, & Analysis, and
Regulatory and QA. We have identified milestones for the essential activities of the ACC within each of
these 6 Cores with a detailed focus on the activities in the first 6 months as activities completed during
this time are most important for ensuring the coordinated, expedited and efficient launch of this Program.
Dr. Thomas, our subject matter experts, senior statistical scientists, and many of the core leads have
substantial experience with NHLBI and thus understand the needs and priorities of the Institute and will
use this knowledge to better collaborate with NHLBI and further speed up the launch of this Program.
We are willing to collaborate with all involved entities as part of the overarching trans-NIH ACTIV
Program as it evolves. We recognize and anticipate that swift adaptation will be required to rapidly
respond to the urgent clinical research needs to address the COVID-19 pandemic.
RTI is uniquely and substantially qualified for the ACC. We will use our team’s broad experience from
many complex coordinating center projects to anticipate the needs for this Program and “hit the ground
running”. Proven informatics technology in use by existing NIH programs will be swiftly modified by
our analysts for speedy deployment of communications platforms. Our organizational size and flexibility
will allow us to ramp up quickly and modify personnel resources flexibly. Lastly, RTI has a proven track
record of successful collaborations with other coordinating centers on complex programs, yet as we are
not directly involved with any Networks for consideration to be NHLBI COVID-19 trials sites, we
provide independence and objectivity to the Program.
RTI国际很高兴根据研究机会的要求提供这份申请
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Tracy L Nolen其他文献
Tracy L Nolen的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Tracy L Nolen', 18)}}的其他基金
Tropical Medicine Research Centers: TMRC Coordinating Center
热带医学研究中心:TMRC 协调中心
- 批准号:
10433111 - 财政年份:2022
- 资助金额:
$ 17149.96万 - 项目类别:
Tropical Medicine Research Centers: TMRC Coordinating Center
热带医学研究中心:TMRC 协调中心
- 批准号:
10609902 - 财政年份:2022
- 资助金额:
$ 17149.96万 - 项目类别:
ACTIV Integration of Host-targeting Therapies for COVID-19 Administrative Coordinating Center
ACTIV 针对 COVID-19 的宿主靶向治疗整合行政协调中心
- 批准号:
10793916 - 财政年份:2020
- 资助金额:
$ 17149.96万 - 项目类别:
ACTIV Integration of Host-targeting Therapies for COVID-19 Administrative Coordinating Center
ACTIV 针对 COVID-19 的宿主靶向治疗整合行政协调中心
- 批准号:
10573859 - 财政年份:2020
- 资助金额:
$ 17149.96万 - 项目类别:
ACTIV Integration of Host-targeting Therapies for COVID-19 Administrative Coordinating Center
ACTIV 针对 COVID-19 的宿主靶向治疗整合行政协调中心
- 批准号:
10171728 - 财政年份:2020
- 资助金额:
$ 17149.96万 - 项目类别:
ACTIV Integration of Host-targeting Therapies for COVID-19 Administrative Coordinating Center
ACTIV 针对 COVID-19 的宿主靶向治疗整合行政协调中心
- 批准号:
10597802 - 财政年份:2020
- 资助金额:
$ 17149.96万 - 项目类别:
相似国自然基金
J-TEXT托卡马克上边界湍流与撕裂模相互作用的实验研究
- 批准号:12375223
- 批准年份:2023
- 资助金额:54 万元
- 项目类别:面上项目
J-TEXT装置外加三维磁场主动调控偏滤器脱靶的实验研究
- 批准号:12305243
- 批准年份:2023
- 资助金额:20 万元
- 项目类别:青年科学基金项目
J-TEXT托卡马克装置上多模式磁扰动对逃逸电流影响研究
- 批准号:
- 批准年份:2022
- 资助金额:30 万元
- 项目类别:青年科学基金项目
J-TEXT托卡马克上边界湍流特性对高密度运行影响的实验研究
- 批准号:11905080
- 批准年份:2019
- 资助金额:26.0 万元
- 项目类别:青年科学基金项目
关于J-TEXT托卡马克上微撕裂模电磁湍流及其输运的实验研究
- 批准号:11605067
- 批准年份:2016
- 资助金额:19.0 万元
- 项目类别:青年科学基金项目
基于J-TEXT远红外偏振干涉仪的相干散射与密度扰动的实验研究
- 批准号:11575067
- 批准年份:2015
- 资助金额:64.0 万元
- 项目类别:面上项目
J-TEXT上外加磁扰动抑制等离子体破裂下逃逸电子产生的实验研究
- 批准号:11275079
- 批准年份:2012
- 资助金额:80.0 万元
- 项目类别:面上项目
J-TEXT托卡马克等离子体粒子输运的密度调制实验研究
- 批准号:11105056
- 批准年份:2011
- 资助金额:26.0 万元
- 项目类别:青年科学基金项目
相似海外基金
EAGER: Integrating Pathological Image and Biomedical Text Data for Clinical Outcome Prediction
EAGER:整合病理图像和生物医学文本数据进行临床结果预测
- 批准号:
2412195 - 财政年份:2024
- 资助金额:
$ 17149.96万 - 项目类别:
Standard Grant
Development of social attention indicators of emerging technologies and science policies with network analysis and text mining
利用网络分析和文本挖掘开发新兴技术和科学政策的社会关注指标
- 批准号:
24K16438 - 财政年份:2024
- 资助金额:
$ 17149.96万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
'And many a strange adventure came my way in that time': Adaptation of the 13th c. French text 'The Quest of the Holy Grail' in 15th c. Ireland.
“在那段时间里,我经历了许多奇怪的冒险”:改编自 13 世纪。
- 批准号:
2506854 - 财政年份:2024
- 资助金额:
$ 17149.96万 - 项目类别:
Studentship
Conference on text production and comprehension by human and artificial intelligence
人类和人工智能文本生成和理解会议
- 批准号:
2422404 - 财政年份:2024
- 资助金额:
$ 17149.96万 - 项目类别:
Standard Grant
自動音声認識を利用したbilingual speech-to-textシステム構築と授業分析への応用
自动语音识别双语语音转文本系统的构建及其在课程分析中的应用
- 批准号:
24K04125 - 财政年份:2024
- 资助金额:
$ 17149.96万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Cyber Graph-to-Text: AI automation for Threat Intelligence, made accessible to all
网络图文转换:威胁情报的人工智能自动化,可供所有人使用
- 批准号:
10052569 - 财政年份:2023
- 资助金额:
$ 17149.96万 - 项目类别:
Investment Accelerator
Applied research towards practical use of Devanagari OCR and utilization of text database
天城文 OCR 实用化和文本数据库利用的应用研究
- 批准号:
23H00564 - 财政年份:2023
- 资助金额:
$ 17149.96万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Develpment of a Method of Text Encoding for Japanese Historical Texts Accoding to Methdological Commons
根据方法论共同点开发日本历史文本文本编码方法
- 批准号:
23H03696 - 财政年份:2023
- 资助金额:
$ 17149.96万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Tradition and the Text/Image: Ed Ruscha's Word Paintings and the Multimodal Legacies of American Modernism
传统与文本/图像:艾德·拉斯查的文字绘画与美国现代主义的多模态遗产
- 批准号:
2875687 - 财政年份:2023
- 资助金额:
$ 17149.96万 - 项目类别:
Studentship
Understanding Processes of Neighborhood Change using Property Text Analytics
使用属性文本分析了解社区变化的过程
- 批准号:
2314726 - 财政年份:2023
- 资助金额:
$ 17149.96万 - 项目类别:
Standard Grant