Ethno-epidemiology of HCV, HIV and Overdose associated with Drug Markets and Drug Tourism

与毒品市场和毒品旅游相关的丙型肝炎病毒、艾滋病毒和药物过量的民族流行病学

• 批准号: 10619365
• 负责人: STEFFANIE A. STRATHDEE
• 金额: $ 5.06万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10619365
• 关键词: 2019-nCoV; Abscess; Area; Automobile Driving; Bathing; COVID-19 pandemic; Cities; Coupled; Data; Data Analyses; Data Collection; Data Set; Defecation; Environment; Epidemiology; Evaluation; Funding; Goals; HIV; Hand; Handwashing; Health; Health behavior; Hepatitis C; Hepatitis C virus; Homelessness; Housing; Human Rights; Hygiene; Incidence; Individual; Inequality; Injecting drug user; Injections; Interview; Location; Mediating; Mexico; Myocarditis; Outcome; Overdose; Persons; Pharmaceutical Preparations; Population; Prevalence; Reporting; Research; Research Personnel; Risk; Risk Behaviors; SARS-CoV-2 exposure; SARS-CoV-2 infection; Sanitation; Seroprevalences; Services; Side; Soaps; Source; Surface; Toilet Facilities; Water; Woman; Work; base; drinking water; drug market; epidemiologic data; experience; follow-up; health disparity; improved; men; metropolitan; non-drug; parent grant; prospective; sex; sociodemographic group; substance use; trend; vulnerable community; wound cleaning

This Diversity Supplement will be conducted based on data obtained from the study Ethno- epidemiology of HCV, HIV and Overdose associated with Drug Markets and Drug Tourism project (R01DA049644, PI: Strathdee), called La Frontera. The overall goal of the parent grant is to characterize trends in incidence of HIV, HCV, and overdose associated with binational drug markets and drug tourism between San Diego and Tijuana, Mexico. La Frontera conducts prospective quantitative and qualitative surveillance of retail drug markets in both San Diego and Tijuana, coupled with epidemiologic data collection of 600 PWID (200 drug tourists from San Diego; 200 non-drug tourists from San Diego and 200 non-drug tourists from Tijuana). This Diversity Supplement is focused on access to water sanitation and hygiene (WASH) among the population of people who inject drugs (PWID) studied in La Frontera, and is planned to be feasibly conducted in the proposed two-year funding period. Data analyses proposed in this supplement will include data from La Frontera conducted among PWID in the Tijuana and San Diego metropolitan area, which was already collected. This dataset included a six-, 12-, and 18-month follow up during the COVID-19 pandemic, representing a valuable opportunity to assess shifts in health behavior and health risks among PWID in both cities. AIM 1 will describe WASH access at baseline interview, and at 6-month follow-up, among men and women who inject drugs in the Tijuana and San Diego metropolitan area, and by housing status during the COVID-19 pandemic period, from October 2020 to December 2021. AIM 2 will determine if limited access to WASH is associated with higher incidence and prevalence of abscesses in injection locations at over an 18-month follow-up period among PWID in the TJ and SD metropolitan area. AIM 3 will examine if limited access to WASH is associated with higher seroprevalence of SARS-CoV-2 infection among PWID in the Tijuana and San Diego metropolitan area. WASH is a human right and is often violated among vulnerable communities such as PWID, and people experiencing housing insecurity. Although access to WASH services has been poorly studied among PWID, there is ample room for concern, as non-hygienic environments or practices could increase risk of developing abscesses, HIV or Hepatitis C complications, and myocarditis. This supplement offers Dr. Calderon Villarreal a unique opportunity to collaborate and mutually strength the understanding of PWID’s unmet needs and how they are driving poor health outcomes and will support her goal to becoming an independent investigator focusing on the intersection between substance use, WASH and health disparities.

该多样性补充将根据从研究Ethno- 与毒品市场和毒品旅游项目相关的HCV、HIV和过量的流行病学 （R 01 DA 049644，PI：Strathdee），称为La Frontera。父母补助金的总体目标是 描述与两国药物市场相关的HIV、HCV和药物过量发生率的趋势 和墨西哥蒂华纳之间的毒品旅游拉弗龙特拉进行前瞻性的 定量和定性监测零售药品市场在圣地亚哥和蒂华纳， 收集了600名PWID（200名来自圣地亚哥的毒品游客; 200名非毒品游客）的流行病学数据， 来自圣地亚哥的游客和来自蒂华纳的200名非毒品游客）。这种多样性补充是 重点是在人口中获得水、环境卫生和个人卫生服务， 在拉弗龙特拉研究了注射毒品（PWID），并计划在 拟议的两年供资期。本附录中提出的数据分析将包括以下数据： La Frontera在蒂华纳和圣地亚哥大都市区的PWID中进行， 已经收集。该数据集包括COVID-19期间的6个月、12个月和18个月随访 大流行，这是评估健康行为和健康风险变化的宝贵机会 在这两个城市中，AIM 1将描述基线访谈和6个月时的WASH接入情况 随访，在蒂华纳和圣地亚哥大都会地区注射毒品的男性和女性中， 及于2020年10月至2021年12月的2019冠状病毒病疫情期间的住房状况。 目的2将确定有限的饮水、环卫和个人卫生服务是否与下列疾病的发生率和流行率较高有关： TJ和SD中PWID在18个月随访期内的注射部位扩张 大都会区。目标3将审查获得讲卫生运动的机会有限是否与较高的 美国圣地亚哥和蒂华纳市PWID中SARS-CoV-2感染的血清阳性率 区WASH是一项人权，在弱势群体（如PWID）中经常受到侵犯， 住房不安全的人。尽管对获得讲卫生运动服务的研究很少， 在PWID中，有足够的关注空间，因为不卫生的环境或做法可能 增加了患乳腺癌、艾滋病毒或丙型肝炎并发症和心肌炎的风险。这 补充提供博士卡尔德龙比利亚雷亚尔一个独特的机会，合作和相互加强， 了解PWID未满足的需求，以及它们如何导致不良的健康结果，并将支持 她的目标是成为一名独立调查员，专注于物质使用， 讲卫生运动和健康差距。