Ethno-epidemiology of HCV, HIV and Overdose associated with Drug Markets and Drug Tourism

这项多样性补充资料将根据从民族研究中获得的数据-- 与药品市场和药品旅游项目相关的丙型肝炎病毒、艾滋病毒和过量用药的流行病学 (R01DA049644，PI：Strathdee)，称为La Frontera。家长助学金的总体目标是 描述与两国药品市场相关的艾滋病毒、丙型肝炎病毒和过量用药的趋势 以及圣地亚哥和墨西哥提华纳之间的毒品旅游。La Frontera进行前瞻性研究 对圣地亚哥和提华纳的药品零售市场进行定量和定性监测 收集了600名PWID的流行病学数据(200名来自圣地亚哥的毒品游客；200名非毒品游客 来自圣地亚哥的游客和来自提华纳的200名非毒品游客)。这份多样性副刊是 侧重于在人口中获得水、环境卫生和个人卫生(环卫) 世卫组织注射毒品(PWID)在La Frontera学习，并计划在 建议的两年资助期。本附录中建议的数据分析将包括来自 La Frontera在提华纳和圣地亚哥大都市区的PWID中进行，这是 已经收好了。该数据集包括在新冠肺炎期间的6个月、12个月和18个月的随访 大流行，为评估健康行为和健康风险的转变提供了宝贵的机会 在两个城市的PWID中。目标1将描述基线面谈和6个月后的洗涤情况 后续，在提华纳和圣地亚哥大都市区注射毒品的男性和女性中， 以及2020年10月至2021年12月新冠肺炎大流行期间的住房状况。 目标2将确定有限的洗涤机会是否与更高的发病率和患病率相关 TJ和SD中PWID注射部位脓肿的18个月随访期 都会区。目标3将检查有限的洗涤途径是否与更高的 提华纳和圣地亚哥大都市PWID人群SARS-CoV-2感染的血清阳性率 区域。WASH是一项人权，在PWID等弱势社区中经常受到侵犯，以及 经历住房不安全的人。尽管人们对获得洗涤服务的研究很少 在PWID中，有充分的空间值得关注，因为不卫生的环境或做法可能 增加发生脓肿、艾滋病毒或丙型肝炎并发症和心肌炎的风险。这 补充剂为卡尔德隆·比利亚雷亚尔博士提供了一个独特的机会来合作和相互加强 了解PWID未得到满足的需求以及这些需求如何导致不良的健康结果，并将支持 她的目标是成为一名独立调查员，专注于药物使用、 洗澡和健康方面的差距。

This Diversity Supplement will be conducted based on data obtained from the study Ethno- epidemiology of HCV, HIV and Overdose associated with Drug Markets and Drug Tourism project (R01DA049644, PI: Strathdee), called La Frontera. The overall goal of the parent grant is to characterize trends in incidence of HIV, HCV, and overdose associated with binational drug markets and drug tourism between San Diego and Tijuana, Mexico. La Frontera conducts prospective quantitative and qualitative surveillance of retail drug markets in both San Diego and Tijuana, coupled with epidemiologic data collection of 600 PWID (200 drug tourists from San Diego; 200 non-drug tourists from San Diego and 200 non-drug tourists from Tijuana). This Diversity Supplement is focused on access to water sanitation and hygiene (WASH) among the population of people who inject drugs (PWID) studied in La Frontera, and is planned to be feasibly conducted in the proposed two-year funding period. Data analyses proposed in this supplement will include data from La Frontera conducted among PWID in the Tijuana and San Diego metropolitan area, which was already collected. This dataset included a six-, 12-, and 18-month follow up during the COVID-19 pandemic, representing a valuable opportunity to assess shifts in health behavior and health risks among PWID in both cities. AIM 1 will describe WASH access at baseline interview, and at 6-month follow-up, among men and women who inject drugs in the Tijuana and San Diego metropolitan area, and by housing status during the COVID-19 pandemic period, from October 2020 to December 2021. AIM 2 will determine if limited access to WASH is associated with higher incidence and prevalence of abscesses in injection locations at over an 18-month follow-up period among PWID in the TJ and SD metropolitan area. AIM 3 will examine if limited access to WASH is associated with higher seroprevalence of SARS-CoV-2 infection among PWID in the Tijuana and San Diego metropolitan area. WASH is a human right and is often violated among vulnerable communities such as PWID, and people experiencing housing insecurity. Although access to WASH services has been poorly studied among PWID, there is ample room for concern, as non-hygienic environments or practices could increase risk of developing abscesses, HIV or Hepatitis C complications, and myocarditis. This supplement offers Dr. Calderon Villarreal a unique opportunity to collaborate and mutually strength the understanding of PWID’s unmet needs and how they are driving poor health outcomes and will support her goal to becoming an independent investigator focusing on the intersection between substance use, WASH and health disparities.