Diversity Supplement: Directing Tryptophan Immunometabolism to Ameliorate Liver Ischemic-Reperfusion Injury

多样性补充剂:引导色氨酸免疫代谢改善肝脏缺血再灌注损伤

基本信息

  • 批准号:
    10632561
  • 负责人:
  • 金额:
    $ 3.75万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-08-01 至 2025-12-31
  • 项目状态:
    未结题

项目摘要

Contact PD/PI: Keselowsky, Benjamin G Project Summary/Abstract Many different disease states and surgical interventions result in a period of inadequate tissue/organ blood supply (i.e., ischemia), that result in reperfusion injury when blood flow is restored, known as ischemia-reperfusion injury (IRI). IRI causes local inflammation, cell death, excessive tissue destruction and possible organ failure. Examples are found in transplantation, trauma, myocardial infarction, stroke, and in particular, IRI is a main cause of liver dysfunction and failure after liver surgery. Unfortunately, there are currently no therapies available in clinical practice addressing IRI, where a major problem is the harmful systemic side effects and toxicities of existing drugs. To address this problem, we are innovating a new therapeutic technology aiming to program immune cells toward a metabolic state blocking excessive inflammation by directing tryptophan metabolism through delivery of an enzyme into circulation. This represents a new class of anti- inflammatory/immunosuppressive biologic drug, with potential to limit systemic toxicities/side effects, and with potential to be significantly less immunocompromising. Lack of treatment options for liver IRI and a catalog of in vivo preliminary data strongly supporting the foundational rationale of IDO as an innovative new anti-inflammatory agent, make this proposal highly significant. Looking to the future, success would open opportunity to expand to other anti-inflammatory applications, for example, pre-conditioning donor grafts for transplantation. Project Summary/Abstract Page 6
联系PD/PI: Keselowsky, Benjamin G

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Benjamin George Keselowsky其他文献

Benjamin George Keselowsky的其他文献

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{{ truncateString('Benjamin George Keselowsky', 18)}}的其他基金

Directing Tryptophan Immunometabolism to Ameliorate Liver Ischemic-Reperfusion Injury
指导色氨酸免疫代谢改善肝脏缺血再灌注损伤
  • 批准号:
    10595020
  • 财政年份:
    2022
  • 资助金额:
    $ 3.75万
  • 项目类别:
Directing Tryptophan Immunometabolism to Ameliorate Liver Ischemic-Reperfusion Injury
指导色氨酸免疫代谢改善肝脏缺血再灌注损伤
  • 批准号:
    10444213
  • 财政年份:
    2022
  • 资助金额:
    $ 3.75万
  • 项目类别:
Functionalized Enzyme Treatments for Dual-Targeting of Inflammation in Spinal Cord Injury
功能化酶治疗脊髓损伤炎症的双重靶向
  • 批准号:
    10284992
  • 财政年份:
    2021
  • 资助金额:
    $ 3.75万
  • 项目类别:
Tissue-Targeted Enzyme for Localized Tryptophan Catabolism to Direct Subcutaneous and Oral Mucosal Inflammatory Responses
用于局部色氨酸分解代谢的组织靶向酶以指导皮下和口腔粘膜炎症反应
  • 批准号:
    9752509
  • 财政年份:
    2017
  • 资助金额:
    $ 3.75万
  • 项目类别:
Tissue-Targeted Enzyme for Localized Tryptophan Catabolism to Direct Subcutaneous and Oral Mucosal Inflammatory Responses
用于局部色氨酸分解代谢的组织靶向酶以指导皮下和口腔粘膜炎症反应
  • 批准号:
    9403768
  • 财政年份:
    2017
  • 资助金额:
    $ 3.75万
  • 项目类别:
Biomaterial Delivery System for Type 1 Diabetes Vaccine
1 型糖尿病疫苗的生物材料输送系统
  • 批准号:
    9285796
  • 财政年份:
    2014
  • 资助金额:
    $ 3.75万
  • 项目类别:
Biomaterial Delivery System for Type 1 Diabetes Vaccine
1 型糖尿病疫苗的生物材料输送系统
  • 批准号:
    8761784
  • 财政年份:
    2014
  • 资助金额:
    $ 3.75万
  • 项目类别:
Dendritic Cell-Targeting Microparticles for Subcellularly-Targeted Delivery of In
用于亚细胞靶向递送 In 的树突状细胞靶向微粒
  • 批准号:
    8707719
  • 财政年份:
    2012
  • 资助金额:
    $ 3.75万
  • 项目类别:
Dendritic Cell-Targeting Microparticles for Subcellularly-Targeted Delivery of In
用于亚细胞靶向递送 In 的树突状细胞靶向微粒
  • 批准号:
    9041572
  • 财政年份:
    2012
  • 资助金额:
    $ 3.75万
  • 项目类别:
Dendritic Cell-Targeting Microparticles for Subcellularly-Targeted Delivery of In
用于亚细胞靶向递送 In 的树突状细胞靶向微粒
  • 批准号:
    8442857
  • 财政年份:
    2012
  • 资助金额:
    $ 3.75万
  • 项目类别:

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