DIABETES PREVENTION / RISK / OMICS / METABOLISM / THERAPY (PROMT) INTERDISCIPLINARY TRAINING

糖尿病预防/风险/组学/代谢/治疗（PROMT）跨学科培训

• 批准号: 10627642
• 负责人: RAMA NATARAJAN
• 金额: $ 7.56万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627642
• 关键词: Diabetes prevention; Metabolism; Risk; Training

PROJECT SUMMARY/ABSTRACT Within the US, the incidence of diabetes is at epidemic proportions. At the same time, technological advancements are offering promising strategies to therapeutically ameliorate diabetes. The Arthur Riggs Diabetes & Metabolism Research Institute (AR-DMRI) at City of Hope (COH) is uniquely poised as a center of translational research excellence with a long-standing record of success in diabetes research. As such, the COH AR-DMRI has a profound commitment to training a diverse next generation of scientific leaders with the skills needed to develop novel technologies and translate them into the clinic. The internationally recognized experts Drs. Debbie Thurmond and Rama Natarajan formalized this commitment by bringing together research mentors from 3 themes: Prevention/Risk/Biomarkers/Omics, Metabolism, and Diabetes Therapy to create the (PROMT) Predoctoral T32 Training Program. The goal of the T32 program is to support outstanding predoctoral students with analytically intensive science education from diverse backgrounds with distinct perspectives to become scientific leaders in diabetes research in line with the NIDDK mission. The PROMT program will admit 2 predoctoral trainees/ year to participate in research across the translational science pipeline. PROMT will provide an unprecedented experience for predoctoral trainees and is predicted to strengthen their commitment to research careers that drive real change in clinical practice. Eligible candidates will be recruited through the Irell & Manella Graduate School of Biological Sciences (IMGS) at COH. After 2 years of IMGS core curriculum, PROMT students will commit to engage in PhD dissertation research and T32 program activities for 2 years. A 3rd year of PROMT training is available by competitive renewal. Trainees will select from among 16 Mentors and 17 Co-Mentors/Clinical Partners that comprise a collaborative group of faculties with a diverse array of interests from basic, translational to clinical science. Research interests of the mentors include islet biology, epigenetics, genomics and metabolomics, adipose and muscle metabolic dysregulation, and human islet transplantation, among others. Program highlights include robust institutional support (Years 1 and 2) and unique research resources on campus, including 3 GMP-compliant manufacturing facilities, and the Helford Clinical Research Hospital. The AR-DMRI is home to the NIDDK-sponsored Integrated Islet Distribution Program (IIDP) and the Human Islet Research Network (HIRN). The T32 curriculum focuses on diabetes and diabetes-related metabolic diseases, with an emphasis on responsible research conduct and reproducibility. Laboratory research, coursework, and translational research internships will be enhanced by regular institutional journal clubs, seminars, and symposia, and a yearly PROMT retreat. The PROMT structure includes an Executive Committee, Internal Advisory Board, External Advisory Board, Curriculum Committee, and Recruitment Committee. The AR- DMRI is in a period of rapid growth, adding new departments and top-level faculty and state-of-the-art facilities, and is pleased to welcome PROMT T32 students into our rigorous training environment.

项目总结/摘要 在美国，糖尿病的发病率处于流行病的比例。同时，技术 这些进展提供了治疗性改善糖尿病的有希望的策略。亚瑟·里格斯 City of Hope（COH）的糖尿病与代谢研究所（AR-DMRI）是一个独特的中心， 卓越的转化研究，在糖尿病研究方面有着长期的成功记录。因此，COH AR-DMRI致力于培养具有以下技能的多元化下一代科学领导者 需要开发新的技术并将其应用于临床。国际公认的专家 Drs.黛比瑟蒙德和拉马纳塔拉詹通过将研究导师聚集在一起，将这一承诺正式化 从3个主题：预防/风险/生物标志物/组学，代谢和糖尿病治疗创建（PROMT） 博士前T32培训计划。T32计划的目标是支持优秀的博士前学生 来自不同背景的分析密集型科学教育，具有不同的视角， 与NIDDK使命一致的糖尿病研究的科学领导者。PROMT计划将承认2 博士前实习生/年参与整个转化科学管道的研究。PROMT将提供 一个前所未有的经验，为博士前学员，预计将加强他们的承诺， 推动临床实践发生真实的变化的研究职业。合格的候选人将通过Irell & Manella Graduate School of Biological Sciences（IMGS）at COH.经过两年的IMGS核心课程， PROMT学生将致力于从事博士论文研究和T32计划活动2年。一 PROMT培训的第三年可通过竞争性续约获得。学员将从16名导师中选出， 17名共同导师/临床合作伙伴，由具有不同兴趣的学院组成 从基础、转化到临床科学。导师的研究兴趣包括胰岛生物学，表观遗传学， 基因组学和代谢组学，脂肪和肌肉代谢失调，以及人类胰岛移植， 还有其他的该计划的亮点包括强大的机构支持（1年和2年）和独特的研究 校园资源，包括3个符合GMP的生产设施，以及赫尔福德临床研究 医院AR-DMRI是NIDDK赞助的综合胰岛分布计划（IIDP）和 人类胰岛研究网络（HIRN）。T32课程的重点是糖尿病和糖尿病相关的代谢 疾病，重点是负责任的研究行为和再现性。实验室研究， 课程和翻译研究实习将通过定期的机构期刊俱乐部得到加强， 研讨会和专题讨论会，以及每年的PROMT务虚会。PROMT的结构包括一个执行委员会， 内部顾问委员会、外部顾问委员会、课程委员会和招聘委员会。AR- DMRI正处于快速发展时期，增加了新的部门和顶级教师和最先进的设施， 并很高兴地欢迎PROMT T32学生进入我们严格的培训环境。