DIABETES PREVENTION / RISK / OMICS / METABOLISM / THERAPY (PROMT) INTERDISCIPLINARY TRAINING

项目摘要/摘要 在美国，糖尿病的发病率处于流行水平。与此同时，技术上的 研究进展为从治疗上改善糖尿病提供了有希望的策略。亚瑟·里格斯夫妇 位于希望之城(COH)的糖尿病与代谢研究所(AR-DMRI)是独一无二的 翻译研究卓越，在糖尿病研究方面有长期的成功记录。因此，卫生与公众服务部 AR-DMRI致力于培养具有以下技能的多样化的下一代科学领导者 需要开发新技术并将其转化为临床。国际公认的专家 黛比·瑟蒙德博士和拉玛·纳塔拉扬博士通过召集研究导师来正式实现这一承诺 从3个主题：预防/风险/生物标记物/有机学，代谢和糖尿病治疗创建(PROMT) 博士后T32培训计划。T32项目的目标是支持优秀的博士前学生 从不同的背景和不同的视角分析密集的科学教育将成为 糖尿病研究领域的科学领导者与NIDDK的使命保持一致。Prompt程序将允许2 博士前实习生/年参与翻译科学管道的研究。Promt将提供 对于博士前实习生来说，这是一种前所未有的体验，预计将加强他们对 在临床实践中推动真正变革的研究职业。合格的候选人将通过Irell招聘 和马内拉生物科学研究生院(IMGS)在COH。经过两年的IMGS核心课程， PROMT学生将承诺参加为期两年的博士论文研究和T32项目活动。一个 第三年的促销培训可通过竞争更新获得。学员将从16名导师和 17名共同导师/临床合作伙伴，由具有不同兴趣的院系组成的协作小组 从基础科学、转化科学到临床科学。导师的研究兴趣包括胰岛生物学、表观遗传学、 基因组学和代谢组学，脂肪和肌肉代谢失调，以及人类胰岛移植， 还有其他的。计划的亮点包括强有力的机构支持(第一年和第二年)和独特的研究 校园内的资源，包括3个符合GMP的制造设施和赫尔福德临床研究中心 医院。AR-DMRI是NIDDK赞助的综合岛屿分配计划(IIDP)的所在地， 人类小岛研究网络(HIRN)。T32课程侧重于糖尿病和糖尿病相关代谢 疾病，强调负责任的研究行为和重现性。实验室研究， 课程作业和翻译研究实习将通过定期的机构期刊俱乐部得到加强， 研讨会、座谈会和一年一度的促进会。促进会结构包括一个执行委员会， 内部咨询委员会、外部咨询委员会、课程委员会和招聘委员会。AR- DMRI正处于快速增长期，增加了新的系和顶尖的教员以及最先进的设施， 并很高兴地欢迎PROMPT T32学员进入我们严谨的培训环境。

PROJECT SUMMARY/ABSTRACT Within the US, the incidence of diabetes is at epidemic proportions. At the same time, technological advancements are offering promising strategies to therapeutically ameliorate diabetes. The Arthur Riggs Diabetes & Metabolism Research Institute (AR-DMRI) at City of Hope (COH) is uniquely poised as a center of translational research excellence with a long-standing record of success in diabetes research. As such, the COH AR-DMRI has a profound commitment to training a diverse next generation of scientific leaders with the skills needed to develop novel technologies and translate them into the clinic. The internationally recognized experts Drs. Debbie Thurmond and Rama Natarajan formalized this commitment by bringing together research mentors from 3 themes: Prevention/Risk/Biomarkers/Omics, Metabolism, and Diabetes Therapy to create the (PROMT) Predoctoral T32 Training Program. The goal of the T32 program is to support outstanding predoctoral students with analytically intensive science education from diverse backgrounds with distinct perspectives to become scientific leaders in diabetes research in line with the NIDDK mission. The PROMT program will admit 2 predoctoral trainees/ year to participate in research across the translational science pipeline. PROMT will provide an unprecedented experience for predoctoral trainees and is predicted to strengthen their commitment to research careers that drive real change in clinical practice. Eligible candidates will be recruited through the Irell & Manella Graduate School of Biological Sciences (IMGS) at COH. After 2 years of IMGS core curriculum, PROMT students will commit to engage in PhD dissertation research and T32 program activities for 2 years. A 3rd year of PROMT training is available by competitive renewal. Trainees will select from among 16 Mentors and 17 Co-Mentors/Clinical Partners that comprise a collaborative group of faculties with a diverse array of interests from basic, translational to clinical science. Research interests of the mentors include islet biology, epigenetics, genomics and metabolomics, adipose and muscle metabolic dysregulation, and human islet transplantation, among others. Program highlights include robust institutional support (Years 1 and 2) and unique research resources on campus, including 3 GMP-compliant manufacturing facilities, and the Helford Clinical Research Hospital. The AR-DMRI is home to the NIDDK-sponsored Integrated Islet Distribution Program (IIDP) and the Human Islet Research Network (HIRN). The T32 curriculum focuses on diabetes and diabetes-related metabolic diseases, with an emphasis on responsible research conduct and reproducibility. Laboratory research, coursework, and translational research internships will be enhanced by regular institutional journal clubs, seminars, and symposia, and a yearly PROMT retreat. The PROMT structure includes an Executive Committee, Internal Advisory Board, External Advisory Board, Curriculum Committee, and Recruitment Committee. The AR- DMRI is in a period of rapid growth, adding new departments and top-level faculty and state-of-the-art facilities, and is pleased to welcome PROMT T32 students into our rigorous training environment.