Training Program for Applied Research and Development in Genomic Medicine

基因组医学应用研究与开发培训计划

• 批准号: 10627222
• 负责人: Julio David Duarte
• 金额: $ 55.42万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-01-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627222
• 关键词: Applied Research; Genomic medicine; Training Programs; research and development

ABSTRACT Healthcare professionals, genomic scientists, and numerous other stakeholders are embracing the advances in healthcare that are possible, and with increasing frequency are being delivered, through approaches that employ genomics to improve care and patient outcomes. To ensure that we can continue to expand upon and deliver the full potential of such an approach requires a highly qualified cadre of clinician-scientists, scientists, and clinicians working collaboratively to advance discoveries and implementation in genomic medicine. This proposal for continuation of our post-doctoral genomic medicine training program, “Program for Applied Research and Development in Genomic Medicine or PARADIGM,” leverages our successes and lessons learned from the first cycle of funding to: 1) refine an integrated training program in genomic medicine, which includes didactic, research, clinical, and professional development activities; 2) recruit promising junior investigators and train them using an interprofessional and interdisciplinary mentoring approach; and 3) evaluate the PARADIGM training program for achievement of learning objectives, success, and long-term productivity and career progress of trainees. This training program for MDs, PharmDs, PhDs, and other clinical specialists at the doctoral level is based on four premises: 1) Genomic medicine must be advanced by a cadre of clinicians and PhD scientists from a variety of specialty areas; 2) a team approach is essential; 3) genomic medicine will require a diverse workforce of leaders; 4) the University of Florida is an ideal environment for this training. To train individuals to meet these needs, PARADIGM will provide a multi-year, integrated, multidisciplinary program comprised of four major components: 1) a Didactic component of required and optional coursework; 2) a Mentored Research component involving a defined research project under the mentorship of an accomplished genomic medicine scientist and clinician; 3) a Clinical Genomic Medicine component that integrates trainees into the genomic medicine clinical practice setting; and 4) a Professional Development component including training in research integrity; administrative, fiscal and regulatory training; and grant-writing skills. Training across these four components will be tailored to the experience and needs of each trainee, but will be concentrated in three cores of expertise at UF: pharmacogenomics, cancer genomics, and disease susceptibility genetics/genomics. The program will be led by two highly accomplished leaders in the field together with a cadre of highly talented, collaborative, multidisciplinary mentors. PARADIGM will undergo continuous evaluation and quality improvement to ensure long-term success of the trainees. Upon program completion, each trainee will be expected to possess knowledge and skills that will enable them to manage the challenges of evidence generation and clinical use of genomic medicine.

抽象的 医疗保健专业人员，基因组科学家以及许多其他利益相关者都在接受进步 可能的医疗保健，随着频率的增加，正在通过使用的方法传递 员工基因组学以改善护理和患者结果。为了确保我们可以继续扩展并 发挥这种方法的全部潜力需要高度合格的临床科学家，科学家， 和临床医生合作，以提高基因组医学的发现和实施。这 延续我们博士后基因组医学培训计划的提案，“应用程序 基因组医学或范式的研发，“利用我们的成功和课程 从第一个资金周期中学到：1）完善基因组医学中的综合培训计划，该计划 包括教学，研究，临床和专业发展活动； 2）招募有前途的大三 调查人员并使用跨专业和跨学科的指导方法训练他们； 3） 评估实现学习目标，成功和长期学习范式培训计划 学员的生产力和职业进步。该MDS，PharmDS，Phd和其他临床的培训计划 博士学位的专家基于四个前提：1）基因组医学必须由干部提升 来自各个专业领域的临床医生和博士学位科学家； 2）团队方法至关重要； 3）基因组 医学将需要领导人的潜水员劳动力； 4）佛罗里达大学是理想的环境 训练。为了培训个人以满足这些需求，范式将提供多年的整合， 多学科计划完成了四个主要组成部分：1）所需的教学成分和 可选课程； 2）指导的研究组成部分涉及一个定义的研究项目 一位成熟的基因组医学科学家和临床的遗传； 3）临床基因组医学 将学员纳入基因组医学临床实践环境的组成部分； 4）专业人士 开发组成部分，包括研究完整性的培训；行政，财政和监管培训； 和赠款技巧。在这四个组件上进行的培训将根据 每个学员，但将集中在UF的三个专业知识中：药物基因组学，癌症基因组学， 和疾病易感性遗传学/基因组学。该计划将由两个高度成就的领导人领导 该领域以及一群才华横溢，合作，多学科的导师。范式会 进行持续的评估和质量改进，以确保培训的长期成功。之上 计划完成计划，每个学员都将拥有知识和技能，使他们能够 管理基因组医学的证据产生和临床使用的挑战。

项目成果

Five-Year Breast Surgeon Experience in LYMPHA at Time of ALND for Treatment of Clinical T1-4N1-3M0 Breast Cancer.

• DOI: 10.1245/s10434-021-10551-8
• 发表时间: 2021-10
• 期刊: Annals of surgical oncology
• 影响因子: 3.7
• 作者: Herremans KM;Cribbin MP;Riner AN;Neal DW;Hollen TL;Clevenger P;Munoz D;Blewett S;Giap F;Okunieff PG;Mendenhall NP;Bradley JA;Mendenhall WM;Mailhot-Vega RB;Brooks E;Daily KC;Heldermon CD;Marshall JK;Hanna MW;Leyngold MM;Virk SS;Shaw CM;Spiguel LR
• 通讯作者: Spiguel LR

It begins with the search committee: Promoting faculty diversity at the source.

首先是遴选委员会：从源头上促进教师多样性。

• DOI: 10.1016/j.amjsurg.2021.08.027
• 发表时间: 2022
• 期刊: American journal of surgery
• 影响因子: 3
• 作者: Arjani,Simran;Tasnim,Sadia;Sumra,Hibba;Zope,Madhushree;Riner,AndreaN;Reyna,Chantal;Henry,Marion;Anand,Tanya
• 通讯作者: Anand,Tanya

ASO Visual Abstract: A 5-Year Breast Surgeon Experience in LYMPHA at Time of ALND for Treatment of Clinical T1-4N1-3M0 Breast Cancer.

ASO 视觉摘要：乳腺外科医生在 ALND 治疗临床 T1-4N1-3M0 乳腺癌时的 5 年淋巴经验。

• 发表时间: 2021
• 期刊: Annals of surgical oncology
• 影响因子: 3.7
• 作者: Herremans,KellyM;Cribbin,MorganP;Riner,AndreaN;Neal,DanW;Hollen,TracyL;Clevenger,Pamela;Munoz,Derly;Blewett,Shannon;Giap,Fantine;Okunieff,PaulG;Mendenhall,NancyP;Bradley,JulieA;Mendenhall,WilliamM;Vega,RaymondBMailhot
• 通讯作者: Vega,RaymondBMailhot

Diversity and Inclusion in Pancreatic Cancer Clinical Trials.

• DOI: 10.1053/j.gastro.2021.06.079
• 发表时间: 2021-12
• 期刊: Gastroenterology
• 影响因子: 29.4
• 作者: Herremans KM;Riner AN;Winn RA;Trevino JG
• 通讯作者: Trevino JG

The clinical implication of minimally invasive versus open pancreatoduodenectomy for non-pancreatic periampullary cancer: a systematic review and individual patient data meta-analysis.

• DOI: 10.1007/s00423-023-03047-4
• 发表时间: 2023-08-15
• 期刊: LANGENBECKS ARCHIVES OF SURGERY
• 影响因子: 2.3
• 作者: Uijterwijk, Bas A.;Kasai, Meidai;Lemmers, Daniel H. L.;Chinnusamy, Palanivelu;van Hilst, Jony;Ielpo, Benedetto;Wei, Kongyuan;Song, Ki Byung;Kim, Song C.;Klompmaker, Sjors;Jang, Jin-Young;Herremans, Kelly M.;Bencini, Lapo;Coratti, Andrea;Mazzola, Michele;Menon, Krishna, V;Goh, Brian K. P.;Qin, Renyi;Besselink, Marc G.;Abu Hilal, Mohammed
• 通讯作者: Abu Hilal, Mohammed