Biospecimen Core

生物样本核心

• 批准号: 10628276
• 负责人: Mark M. Pomerantz
• 金额: $ 21.91万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628276
• 关键词: Acceleration; Animal Model; Antibodies; Award; Bar Codes; Biocompatible Materials; Biological Assay; Biological Specimen Banks; Biometry; Biopsy; Blood; Cancer Center; Cancer Patient; Cellularity; Clinical; Clinical Data; Collection; Computational Biology; Computer-Assisted Image Analysis; Confidentiality of Patient Information; Consent; DNA; Dana-Farber Cancer Institute; Data; Data Analyses; Data Collection; Data Management Resources; Databases; Development; Ensure; Equipment and supply inventories; Evaluation; Formalin; Freezing; Future; General Hospitals; Goals; Hospitals; Human; Imaging technology; Immunofluorescence Immunologic; Immunohistochemistry; Infrastructure; Institution; Israel; Link; Malignant neoplasm of prostate; Massachusetts; Medical center; Molecular; Molecular Analysis; Outcome; Paraffin Embedding; Pathologic; Pathology; Patients; Performance; Pre-Clinical Model; Procedures; Process; Prostate; Prostatectomy; Prostatic Neoplasms; Proteins; Protocols documentation; Public Health Schools; Quality Control; RNA; Research Personnel; Research Project Grants; Resources; Sampling; Secure; Services; Shipping; Slide; Specimen; Stains; Standardization; System; Technology; Tissue Microarray; Tissue Model; Tissues; Translational Research; Validation; Woman; Work; biobank; cancer Biomedical Informatics Grid; career; clinical database; experimental study; human model; human tissue; laser capture microdissection; mouse model; neoplastic; novel; programs; sample collection; success; tissue fixing; tool; tumor

PROJECT SUMMARY – BIOSPECIMEN CORE (CORE C) Acquisition and characterization of biospecimens linked with clinical data and the development of patient­ relevant preclinical models, are essential components for effective and impactful translational research. The Dana Farber/ Harvard Cancer Center (DF/HCC) Prostate SPORE Biospecimen Core (Core C) will maintain and expand a mature prostate cancer biorepository, including blood and tissue specimens, from a diverse group of prostate cancer patients across DF/HCC who have provided consent to our clinical database and biobank protocols. Core C will provide tissue specimens and vast pathology expertise to SPORE investigators including the evaluation of both human and mouse model tissues. Core C will maintain a database of clinical data on all consented patients, linked with standardized pathology review procedures and data collection. Core C will work closely with SPORE investigators and collaborators to provide interpretative and consultative pathology services, including state­of­the­art molecular assays and imaging technologies developed at DF/HCC. Centralization of Core activities builds upon established infrastructure but does not replicate existing resources within the DF/HCC. Overall, Core C will greatly facilitate and accelerate translational research within the DF/HCC Prostate SPORE through the collection and integration of highly annotated biological material and associated clinical information.

项目总结-生物样本核心（核心C） 与临床数据相关的生物标本的采集和表征以及 与患者相关的临床前模型，是有效和有影响力的翻译的重要组成部分， research. Dana Farber/哈佛癌症中心（DF/HCC）前列腺孢子生物标本核心（核心 C）将维持和扩大成熟的前列腺癌生物储存库，包括血液和组织标本， 来自DF/HCC中的不同前列腺癌患者组，他们同意我们的临床研究。 数据库和生物库协议核心C将提供组织标本和丰富的病理学专业知识， SPORE研究者，包括人和小鼠模型组织的评价。核心C将 维护所有同意患者的临床数据数据库，并与标准化病理学审查相关联 程序和数据收集。核心C将与SPORE调查人员和合作者密切合作， 提供解释性和咨询性病理学服务，包括最先进的分子检测 DF/HCC开发的成像技术。核心活动的集中化建立在 建立基础设施，但不复制DF/HCC内的现有资源。总体而言，核心C 将大大促进和加速DF/HCC前列腺SPORE内的转化研究， 高度注释的生物材料和相关临床信息的收集和整合。