Administration Core

摘要-行政核心 青少年电子烟的流行正在威胁着青少年的健康和福祉。拟议项目（A 多学科评估的风险Vaping在早期的生活”-项目奇迹）采取了综合 多学科方法，以评估青年vaping对健康的影响，与系统合作， 最直接受到青少年电子烟的影响，并且能够进行干预以减少潜在的 负面健康影响-学校。为了实现这一总体目标，MARVEL项目汇集了专业知识， 在青少年发展，成瘾，烟草监管科学，纵向研究方法，脑 发展，呼吸健康，生物标志物，多组学，生物统计学，社区参与和健康 通信MARVEL项目包括四个创新和综合项目，将决定 vaping对依赖性和幸福感的影响（项目1），大脑健康以及认知和心理社会 发展（项目2）和呼吸健康（项目3），并利用这些健康信息，连同沿着 现有文献开发健康传播信息，重点关注vaping如何影响青少年 健康和生活（项目4）。这些项目由提供关键服务的四个核心提供支持 包括：（1）行政支持;（2）生物统计专业知识;（3）促进与 青少年，包括招募和保留;（4）暴露/效应的生物标志物，以及 产品成分，产生的气溶胶。开展转化型和参与型青少年 在Project MARVEL中提出的研究是具有挑战性的。它要求监督大型和复杂的项目， 核心，研究人员之间的协调;促进不同学科之间的科学整合;以及 克服成功实施科学方法的许多实际挑战所需的经验 协议.行政核心旨在通过以下三个具体方面应对这些挑战 目标：1）管理业务，包括行政，财务和监管职能; 2）促进科学 讨论和整合; 3）协调科学发现的传播。为了实现这些目标， 行政核心将监督定期会议，组织旅行和报销;提供预算 监督所有项目和核心;监督人类受试者的保护，临床试验的注册，以及 报告的生成。行政核心还将组织定期讨论与以下方面有关的主题： 青年vaping通过每月的科学研讨会和年度科学务虚会/外部咨询委员会 会议，支持科学报告，手稿的发展，并提交给联邦 在三个研究项目之间以及外部实施数据共享政策， 计划项目。最后，行政核心将聘请专家担任外部咨询委员会成员， 审查MARVEL的近期和长期目标，监控实现这些目标的进展，并 为研究设计、结果解释和翻译工作提供意见。

ABSTRACT – ADMINISTRATIVE CORE The epidemic of youth vaping is threatening the health and well-being of adolescents. The proposed project (“A Multidisciplinary Assessment of Risks of Vaping in Early Life” - Project MARVEL) takes an integrated multidisciplinary approach to assess the impact of youth vaping on health in collaboration with the system that is most directly impacted by adolescent vaping and is well-positioned to intervene to reduce the potential negative health impact - schools. To achieve this overarching goal, Project MARVEL brings together expertise in adolescent development, addiction, tobacco regulatory science, longitudinal research methods, brain development, respiratory health, biomarkers, multi-omics, biostatistics, community engagement, and health communication. Project MARVEL includes four innovative and integrative projects that will determine the impact of vaping on dependence and well-being (Project 1), brain health and cognitive and psychosocial development (Project 2), and respiratory health (Project 3), and leverage this health information, along with the extant literature to develop health communication messages focused on how vaping affects adolescents’ health and lives now (Project 4). These projects are supported by four cores that provide critical services including: (1) administrative support; (2) biostatistical expertise; (3) facilitation with conducting research with adolescents, including recruitment and retention; and (4) biomarkers of exposure/effect, and measurement of product constituents, generated aerosols. Conducting the type of translational and participatory adolescent research proposed in Project MARVEL is challenging. It requires oversight of large and complex projects and cores, coordination between researchers; facilitation of scientific integration across different disciplines; and the experience required to overcome many practical challenges to the successful implementation of scientific protocols. The Administrative Core was designed to address each of these challenges through three specific aims: 1) Manage operations including administrative, financial, and regulatory functions; 2) Facilitate scientific discussion, and integration; 3) Coordinate dissemination of scientific findings. To address these aims, the Administrative Core will oversee regular meetings, organize travel and reimbursements; provide budgetary oversight for all projects and cores; and oversee human subjects’ protections, registration of clinical trials, and the generation of reports. The Administrative Core will also organize regular discussion of topics related to youth vaping through a monthly scientific seminar and an annual scientific retreat/external advisory board meeting, support the development of scientific presentations, manuscripts, and submissions to the federal docket, and implement policies for data sharing across the three research projects, as well as external to the Program Project. Lastly, the Administrative Core will engage experts to serve on an External Advisory Board to review the immediate and long-term goals of MARVEL, to monitor progress towards these goals, and to provide input on study design study design, interpretation of results, and translational efforts.