Administration Core

行政核心

• 批准号: 10628255
• 负责人: Erin L Sutfin
• 金额: $ 38.96万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-03 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628255
• 关键词: Address; Adolescent; Adolescent Development; Aerosols; Affect; Behavior; Benchmarking; Biological Markers; Biometry; Brain; Cancer Center Support Grant; Characteristics; Cigarette; Clinical Trials; Collaborations; Communication; Complex; Dependence; Development; Discipline; Endowment; Ensure; Epidemic; Evaluation; Funding; Generations; Goals; Grant; Health; Health Policy; Lead; Life; Literature; Manuscripts; Measurement; Medicine; Monitor; National Institute of Drug Abuse; Nicotine; Nicotine Dependence; North Carolina; Oncology; Personal Satisfaction; Pharmacology; Physiology; Pilot Projects; Play; Policies; Positioning Attribute; Principal Investigator; Process; Protocols documentation; Psychology; Public Health; Reporting; Research; Research Design; Research Methodology; Research Personnel; Research Project Grants; Research Support; Risk Assessment; Role; Schools; Science; Science Policy; Services; Social Sciences; System; Tobacco; Toxicology; Travel; U-Series Cooperative Agreements; United States National Institutes of Health; Universities; Work; Youth; addiction; adolescent health; brain health; cognitive development; community engagement; data sharing; design; experience; forest; health communication; human subject protection; innovation; interdisciplinary approach; meetings; multidisciplinary; multiple omics; operation; prevent; professor; programs; psychosocial development; recruit; respiratory health; smoking cessation; success; tobacco control; tobacco regulatory science; vaping

ABSTRACT – ADMINISTRATIVE CORE The epidemic of youth vaping is threatening the health and well-being of adolescents. The proposed project (“A Multidisciplinary Assessment of Risks of Vaping in Early Life” - Project MARVEL) takes an integrated multidisciplinary approach to assess the impact of youth vaping on health in collaboration with the system that is most directly impacted by adolescent vaping and is well-positioned to intervene to reduce the potential negative health impact - schools. To achieve this overarching goal, Project MARVEL brings together expertise in adolescent development, addiction, tobacco regulatory science, longitudinal research methods, brain development, respiratory health, biomarkers, multi-omics, biostatistics, community engagement, and health communication. Project MARVEL includes four innovative and integrative projects that will determine the impact of vaping on dependence and well-being (Project 1), brain health and cognitive and psychosocial development (Project 2), and respiratory health (Project 3), and leverage this health information, along with the extant literature to develop health communication messages focused on how vaping affects adolescents’ health and lives now (Project 4). These projects are supported by four cores that provide critical services including: (1) administrative support; (2) biostatistical expertise; (3) facilitation with conducting research with adolescents, including recruitment and retention; and (4) biomarkers of exposure/effect, and measurement of product constituents, generated aerosols. Conducting the type of translational and participatory adolescent research proposed in Project MARVEL is challenging. It requires oversight of large and complex projects and cores, coordination between researchers; facilitation of scientific integration across different disciplines; and the experience required to overcome many practical challenges to the successful implementation of scientific protocols. The Administrative Core was designed to address each of these challenges through three specific aims: 1) Manage operations including administrative, financial, and regulatory functions; 2) Facilitate scientific discussion, and integration; 3) Coordinate dissemination of scientific findings. To address these aims, the Administrative Core will oversee regular meetings, organize travel and reimbursements; provide budgetary oversight for all projects and cores; and oversee human subjects’ protections, registration of clinical trials, and the generation of reports. The Administrative Core will also organize regular discussion of topics related to youth vaping through a monthly scientific seminar and an annual scientific retreat/external advisory board meeting, support the development of scientific presentations, manuscripts, and submissions to the federal docket, and implement policies for data sharing across the three research projects, as well as external to the Program Project. Lastly, the Administrative Core will engage experts to serve on an External Advisory Board to review the immediate and long-term goals of MARVEL, to monitor progress towards these goals, and to provide input on study design study design, interpretation of results, and translational efforts.

抽象行政核心 青少年蒸发的流行正在威胁青少年的健康和福祉。建议的项目(“A” 早期吸管风险的多学科评估“-漫威项目)采取综合 与以下系统协作，采用多学科方法评估青年蒸发对健康的影响 最直接受到青少年吸食的影响，并处于有利地位进行干预，以降低潜在的 对健康的负面影响--学校。为了实现这一首要目标，漫威项目汇集了专业知识 青少年发展、成瘾、烟草调控科学、纵向研究方法、大脑 发展、呼吸健康、生物标志物、多组学、生物统计学、社区参与和健康 沟通。漫威项目包括四个创新的综合项目，这些项目将决定 蒸发对依赖和幸福感(项目1)、大脑健康以及认知和心理社会的影响 发展(项目2)和呼吸健康(项目3)，并利用这些健康信息，以及 现有文献重点研究电子烟如何影响青少年的健康交流信息 现在的健康和生活(项目4)。这些项目由提供关键服务的四个核心支持 包括：(1)行政支助；(2)生物统计学专门知识；(3)协助开展研究 青少年，包括招募和留住；和(4)暴露/影响的生物标志物，以及 产品成分，产生的气雾剂。引导翻译型和参与型青少年 漫威计划中提出的研究是具有挑战性的。它需要监督大型和复杂的项目，并 核心，研究人员之间的协调；促进跨不同学科的科学整合；以及 克服许多实际挑战所需的经验成功地实施科学 协议。管理核心旨在通过三个具体的解决方案来应对这些挑战 目标：1)管理业务，包括行政、财务和监管职能；2)促进科学 讨论和整合；3)协调科学成果的传播。为了实现这些目标， 行政核心将监督定期会议，组织差旅和报销；提供预算 监督所有项目和核心；监督人体受试者的保护、临床试验注册和 报告的生成。行政核心还将定期组织有关下列主题的讨论 青年通过每月一次的科学研讨会和一年一度的科学务虚会/外部顾问委员会进行蒸发 会议，支持开发科学演示文稿、手稿和提交给联邦政府 摘要，并实施跨三个研究项目以及外部的数据共享政策 计划项目。最后，行政核心将聘请专家在外部咨询委员会任职，以 回顾漫威的近期和长期目标，监控实现这些目标的进展情况，并 为研究设计、研究设计、结果解释和翻译工作提供意见。