EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation TO Reduce Atrial Fibrillation Burden and Correlation with Exercise CapacitY: EXCLAMATORY Longitudinal Study
消融后对左心房力学进行运动心脏磁共振评估以减少心房颤动负担及其与运动能力的相关性:感叹号纵向研究
基本信息
- 批准号:10740318
- 负责人:
- 金额:$ 18.16万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-15 至 2028-07-31
- 项目状态:未结题
- 来源:
- 关键词:AblationActivities of Daily LivingAffectArrhythmiaAtrial FibrillationAtrial FunctionBicyclingCardiacCardiac ablationCardiomyopathiesCardiopulmonaryCardiovascular systemClinical ResearchContractsDataDevelopmentDiagnosticDiastoleDiseaseEchocardiographyEnvironmentEvaluationExerciseExercise PhysiologyExercise TestExertionFunctional disorderFutureGoalsHeartHeart AtriumHeart DiseasesHeart RateHeart failureImpairmentIncidenceIndividualInstitutionLeadLearningLeftLeft Atrial FunctionLeft Ventricular FunctionLeft atrial structureLiteratureLongitudinal StudiesMagnetic ResonanceMagnetic Resonance ImagingMeasurementMeasuresMechanicsMentorsMethodsModalityOxygen ConsumptionPatientsPerformancePhenotypePositioning AttributePrincipal InvestigatorPublishingRegulationResearchResearch MethodologyResearch PersonnelResearch Project GrantsRestRiskRoleSinusStroke VolumeStructureSupinationTechniquesTherapeutic InterventionTrainingVentricularWritingcardiac magnetic resonance imagingcardiovascular imagingcareercommon treatmentdesignexercise capacityexercise intoleranceexperienceheart functionhigh riskimprovedinnovationinterestknowledge basemultidisciplinarynoninvasive diagnosispatient orientedpotential biomarkerprogramsprospectivestatisticstargeted treatmenttraining project
项目摘要
PROJECT SUMMARY
Atrial fibrillation is a highly prevalent condition resulting in disordered contraction of the atria (top chambers of
the heart). It affects one in four individuals during their lifetime. It is known that the arrhythmia has a
bidirectional relationship with dysfunctional atrial contraction, a condition which itself is becoming understood
as a means by which individuals may develop heart failure. However, the majority of published literature to
date involves examining atrial function while lying supine at rest, thus incompletely characterizing the varying
states of exertion that one experiences during activities of daily living. Exercise-based cardiovascular magnetic
resonance imaging is a powerful non-invasive diagnostic modality that can measure heart function during
exercise and has the potential to uncover key mechanisms by which patients with atrial fibrillation may
progress to overt heart failure – and whether current treatment techniques (namely, catheter ablation) may
alter that trajectory.
The broad goal of this application is to facilitate training of the principal investigator, Dr. Cory Trankle, MD, for a
career as a patient-centered independent researcher who uses exercise-based diagnostic modalities (including
magnetic resonance imaging), with a specific interest in characterizing mechanisms of exercise limitations
such as left atrial dysfunction and identifying them as potential biomarkers and targets for therapeutic
interventions. In addition to didactic coursework and subspecialty seminars, Dr. Trankle will lead a
multidisciplinary team conducting a prospective clinical study investigating the effects that catheter ablation for
atrial fibrillation has on atrial function during exercise. He will address three specific aims in patients with atrial
fibrillation undergoing catheter ablation: (1) determine the effects of ablation on the ability of the left atrium to
augment its function during exercise, (2) determine the impacts ablation on left ventricular performance during
exercise, and (3) determine whether those changes experienced in left ventricular performance are indeed
associated with changes in left atrial function. A better understanding of the impact of catheter ablation, a
common treatment for atrial fibrillation, has on these cardiac structures during exercise has the potential to
identify those at highest risk for heart failure incidence and lead to more targeted treatment in this highly
prevalent disease.
项目总结
项目成果
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Cory Trankle其他文献
Cory Trankle的其他文献
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