Body Region Specificity for Neuromodulation of the Gut-Brain Axis in Functional Dyspepsia

项目摘要/摘要 应聘者是一位成就卓著的生物工程师，在人脑-身体成像方面接受过正式培训，并 神经调节，以及致力于综合医学研究中的翻译研究 和神经胃肠病学。候选人的长期职业目标是开发一项翻译研究计划 在综合医学中，肠道-大脑调节的方法。应聘者的短期职业目标为1) 通过集中于综合医学、安慰剂研究、 和神经胃肠病学；2)将新的研究技能编织到她的技术成像背景中，具有潜力 用于评估非药物疗法的纵向研究；3)提供数据和出版物 过渡到成功的R01应用程序所必需的。这份申请概述了机构承诺， 研究计划、职业发展活动和关键导师的参与，以确保候选人完成任务 这些目标。在最近发表的工作中，候选人展示了使用动态电影的可行性- 磁共振成像无创性评价正常人和慢性胃炎患者胃功能的多方面研究 功能性消化不良(FD)。在这份提案中，候选人寻求应用基于MRI的工具来比较影响 不同穴位刺激对FD患者脑干神经回路和胃动力的影响 以及治疗和预期操纵之间的相互作用。 本研究的具体目标是：1)评估经皮穿刺术中潜在的脑干神经回路。 穴位电刺激治疗功能性消化不良2)比较足(ST36)穴与腹部电刺激的疗效 (穴位ST25)茶对FD患者胃动力的影响；3)评估预期手法对饮食的影响。 诱发的症状和生理结果。作为这项提议的一个组成部分，候选人的职业生涯 发展将通过参加高级课程来补充，以发展安慰剂方面的专业知识 研究、综合医学、胃肠病学和进行临床试验。一个正式的指导委员会， 由多学科专家组成，包括安慰剂研究、神经胃肠病学、神经成像、针灸、 和综合医学，将为候选人实现她的目标提供监督、指导和帮助 目标。研究环境包括斯波尔丁康复医院、阿蒂努拉A。 Martinos生物医学成像中心，整合疼痛神经成像中心(CiPNI)， 胃肠单位和MGH神经肠道健康中心，哈佛医学院将提供 丰富、协作和智力激发的氛围，确保候选人的成功。通过这件事 获奖后，候选人将成为一名独立的调查员，有助于我们理解 在肠脑相互作用障碍患者中支持穴位特异性效应的脑-肠道机制。

PROJECT SUMMARY/ABSTRACT The candidate is an accomplished bioengineer with formal training in human brain-body imaging and neuromodulation, and a commitment to a career in translational research in the study of integrative medicine and neurogastroenterology. The candidate’s long-term career goal is to develop a translational research program in integrative medicine approaches for gut-brain modulation. The candidate’s short-term career goals are to 1) transition towards independence through mentored training focused on integrative medicine, placebo research, and neurogastroenterology; 2) weave new research skills into her technical imaging background, with potential for longitudinal studies evaluating non-pharmacological therapies; 3) produce the data and publications necessary to transition into a successful R01 application. This application outlines the institutional commitment, research plan, career development activities, and key mentors involved to ensure the candidate accomplishes these goals. In recently published work, the candidate has demonstrated the feasibility of using dynamic cine- MRI for non-invasive characterization of multiple aspects of gastric function in healthy subjects and patients with functional dyspepsia (FD). In this proposal, the candidate seeks to apply MRI-based tools to compare the impact of stimulation at different acupoint locations on brainstem neurocircuitry and gastric motility in patients with FD, as well as the interaction between treatment and expectancy manipulation. The specific goals of this study are to 1) evaluate the underlying brainstem neurocircuitry of transcutaneous electrical acupoint stimulation (TEAS) in FD; 2) compare the effect of leg (acupoint ST36) versus abdomen (acupoint ST25) TEAS on gastric motility in FD; 3) evaluate the effect of expectancy manipulation on meal- evoked symptoms and physiological outcomes. As an integral part of this proposal, the candidate’s career development will be complemented by participation in advanced coursework to develop expertise in placebo research, integrative medicine, gastroenterology, and conduct of clinical trials. A formal mentorship committee, consisting of multidisciplinary experts in placebo research, neurogastroenterology, neuroimaging, acupuncture, and integrative medicine, will provide supervision, guidance, and assistance for the candidate to achieve her goals. The research environment, which includes the Spaulding Rehabilitation Hospital, the Athinoula A. Martinos Center for Biomedical Imaging, the Center for Integrative Pain Neuroimaging (CiPNI), the Gastrointestinal Unit and MGH Center for Neurointestinal Health, and the Harvard Medical School will provide a rich, collaborative, and intellectually stimulating atmosphere to ensure the candidate’s success. Through this award, the candidate will emerge as an independent investigator by contributing to our understanding of the brain-gut mechanisms supporting acupoint-specific effects in patients with a disorder of gut-brain interactions.