探讨全反式视黄酸和 PD-1 抑制治疗的人类受试者和 IDH 突变神经胶质瘤小鼠模型的抗肿瘤免疫机制-猫眼课题宝

探讨全反式视黄酸和 PD-1 抑制治疗的人类受试者和 IDH 突变神经胶质瘤小鼠模型的抗肿瘤免疫机制

批准号：

10739154

负责人：

Nduka Mgbechinyere Amankulor

金额：

$68.31万

依托单位：

UNIVERSITY OF PENNSYLVANIA

依托单位国家：

美国

项目类别：

财政年份：

2023

资助国家：

美国

项目状态：

未结题

起止时间：

2023-07-03 至 2028-06-30

来源：

https://reporter.nih.gov/project-details/10739154

关键词：

Address Adjuvant Age Antibodies Biological Markers Blood Brain Brain Neoplasms CD4 Positive T Lymphocytes CD8-Positive T-Lymphocytes CD8B1 gene Cells Cessation of life Chemotherapy and/or radiation Clinical Clinical Trials Combined Modality Therapy Data Development Diffuse Disease remission Dose Epigenetic Process Evaluation Excision Exclusion Exhibits Future Gene Expression Profile Genetic Transcription Genotype Glioma Goals Hematologic Neoplasms Human Immune Immune checkpoint inhibitor Immune system Immunocompetent Immunologic Markers Immunologic Monitoring Immunologic Surveillance Immunologics Immunosuppression Immunotherapeutic agent Immunotherapy Infiltration Inflammatory Institutional Review Boards Interferon Type II Interferons Isocitrate Dehydrogenase Knowledge Lymphocyte Lymphocyte Function Lymphocytic Infiltrate Malignant - descriptor Malignant Neoplasms Malignant neoplasm of brain Mediating Mediator Modality Modeling Mus Mutation Myelogenous Myeloid-derived suppressor cells Natural Killer Cells Neoadjuvant Therapy Operative Surgical Procedures Output PD-1 inhibitors Pathway interactions Patients Pennsylvania Performance Phase II Clinical Trials Population Prediction of Response to Therapy Recurrence Regimen Regulatory T-Lymphocyte Reporting Resistance Retinoids Sampling Series Signal Pathway Signal Transduction Sleeping Beauty Solid Specificity Specimen T cell receptor repertoire sequencing T-Cell Activation T-Cell Receptor T-Lymphocyte T-Lymphocyte and Natural Killer Cell Techniques Testing Therapeutic Therapeutically Targetable Tissues Tretinoin Tumor Biology Tumor Immunity Tumor Tissue Tumor-Infiltrating Lymphocytes Universities Validation XCL1 gene cell type checkpoint inhibition clinical efficacy cohort design epigenetic silencing exhaustion experimental study gene network genetic signature human subject immune checkpoint blockade immunogenic immunogenicity mouse model mutant neoplastic cell pre-clinical predicting response programmed cell death protein 1 response restoration small molecule specific biomarkers transcriptome sequencing treatment response tumor tumor eradication young adult

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Project Abstract Diffuse gliomas are fatal brain tumors that respond poorly to current immunotherapies. Using both mice models and human clinical trial data, we propose a series of experiments to identify immune biomarkers and key immune cell types that predict tumor responsiveness to therapy. These results will further our understanding of brain tumor biology and inform the future development of new treatment modalities.

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海外基金

Interrogating Mechanisms of Anti-tumor Immunity in Human Subjects and Murine Models of IDH-Mutant Glioma Treated with All-Trans Retinoic Acid and PD-1 Inhibition

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