Long-acting naltrexone for pre-release prisoners: A randomized trial of mobile treatment
长效纳曲酮用于释放前囚犯:流动治疗的随机试验
基本信息
- 批准号:10738933
- 负责人:
- 金额:$ 44.41万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-05-01 至 2025-04-30
- 项目状态:未结题
- 来源:
- 关键词:AdherenceAsianAustraliaBaltimoreCanadaCitiesCommunitiesCorrectional InstitutionsCriminal JusticeDiseaseDropsEuropeanGenderGeneral PopulationHIV riskHIV/AIDSImprisonmentIndividualInfectionInformed ConsentInjectableInjectionsIntoxicationMarylandMedicalNaloxoneNaltrexoneNeedlesOpioidOralOutcomeParticipantPatientsPharmaceutical PreparationsPrisonerPrisonsPublic HealthRandomizedResourcesRisk BehaviorsSafetyServicesSystemTestingUrineWomanaddictioncosteffectiveness evaluationhigh risk sexual behaviorimprovedinnovationmedical examinationmenmetropolitanopioid treatment programopioid useopioid use disorderoverdose deathrandomized trialrandomized, clinical trialsrearrestreincarcerationresidencescreeningsubstance use treatmenttreatment adherence
项目摘要
Abstract
Disorders involving opioid use are a severe problem among jail and prison inmates. Inmates in the US,
Canada, Australia, and many European and Asian nations have disproportionately higher rates of opioid use
disorders than their general populations. Scarce resources are provided for corrections-based substance use
treatment in many nations, and many inmates with OUDs remain untreated. The use of long-acting, injectable
naltrexone (XR-NTX) may be a promising form of treatment for pre-release prisoners. Naltrexone blocks the
intoxicating and reinforcing effects of opioids, but has no opioid-like effects. This proposed five-year study will
focus on whether the addition of providing XR-NTX treatment at a patients’ place of residence will increase
adherence and thus efficacy of the medication. Project implementation will occur at five pre-release prisons
under the jurisdiction of the Maryland Department of Public Safety and Correctional Services (MDPSCS): 1)
Metropolitan Transition Center (MTC) for men; 2) Baltimore Pre-Release Unit (BPRU) for men; 3) Jessup Pre-
Release Unit (JPRU) for men; 4) Baltimore City Correctional Center (BCCC) and 5) Maryland Correctional
Institution (MCI) for Women. Following initial screening, informed consent, and medical examination, pre-
release prisoners at each facility will be block randomized (N=240) within gender to either: Condition 1. XR-
NTX-OTx (n=120): One injection of XR-NTX in prison, followed by six monthly injections post-release in the
community at an opioid treatment program; or Condition 2. XR-NTX+MMTx (n=120): One injection of XR-NTX
in prison, followed by six monthly injections post-release in the community at the patient’s place of residence.
All participants will be confirmed opiate-free by urine test and negative naloxone and oral naltrexone tests, and
evaluated monthly for seven months and 12 months after release from prison. The proposed study has two
specific aims: Aim1. To compare the two study conditions in terms of: a) XR-NTX treatment adherence; b)
opioid use; c) criminal activity; d) re-arrest; e) re-incarceration; and f) HIV risk-behaviors (i. needle use; ii. risky
sexual behaviors). Aim 2. To determine if the number of months of post-release XR-NTX treatment is related to
outcome (a-f above), and if so, is there a point at which XR-NTX v. Non-XR-NTX equilibrates? This would help
determine the number of injections, important because of XR-NTX cost. Many individuals in the criminal justice
system drop out of treatment and therefore increasing ways to improve adherence by attempting to: 1) expand
capacity; and 2) implement access by providing treatment at their place of residence may positively impact
outcomes.
摘要
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A clinical protocol of a comparative effectiveness trial of extended-release naltrexone versus extended-release buprenorphine with individuals leaving jail.
- DOI:10.1016/j.jsat.2020.108241
- 发表时间:2021-09
- 期刊:
- 影响因子:3.9
- 作者:Gordon MS;Mitchell SG;Blue TR;Vocci FJ;Fishman MJ;Murphy SM;Couvillion K;Maher K;Ryan D;Wenzel K;Danner ML;Jarvis DK
- 通讯作者:Jarvis DK
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Michael Scott Gordon其他文献
Michael Scott Gordon的其他文献
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{{ truncateString('Michael Scott Gordon', 18)}}的其他基金
A comparative effectiveness trial of extended release naltrexone versus extended-release buprenorphine with individuals leaving jail
缓释纳曲酮与缓释丁丙诺啡对出狱人员的效果比较试验
- 批准号:
10160255 - 财政年份:2019
- 资助金额:
$ 44.41万 - 项目类别:
A comparison of Sublingual and Extended-Release Buprenorphine for Individuals Leaving Jail
舌下含服和缓释丁丙诺啡对出狱人员的比较
- 批准号:
10547922 - 财政年份:2019
- 资助金额:
$ 44.41万 - 项目类别:
A comparative effectiveness trial of extended release naltrexone versus extended-release buprenorphine with individuals leaving jail
缓释纳曲酮与缓释丁丙诺啡对出狱人员的效果比较试验
- 批准号:
10616501 - 财政年份:2019
- 资助金额:
$ 44.41万 - 项目类别:
A comparative effectiveness trial of extended release naltrexone versus extended-release buprenorphine with individuals leaving jail
缓释纳曲酮与缓释丁丙诺啡对出狱人员的效果比较试验
- 批准号:
9978020 - 财政年份:2019
- 资助金额:
$ 44.41万 - 项目类别:
A comparative effectiveness trial of extended release naltrexone versus extended-release buprenorphine with individuals leaving jail
缓释纳曲酮与缓释丁丙诺啡对出狱人员的效果比较试验
- 批准号:
10388285 - 财政年份:2019
- 资助金额:
$ 44.41万 - 项目类别:
Buprenorphine for probationers and parolees: Bridging the gap into treatment
丁丙诺啡用于缓刑犯和假释犯:缩小治疗差距
- 批准号:
9898338 - 财政年份:2018
- 资助金额:
$ 44.41万 - 项目类别:
Buprenorphine for probationers and parolees: Bridging the gap into treatment
丁丙诺啡用于缓刑犯和假释犯:缩小治疗差距
- 批准号:
10610309 - 财政年份:2018
- 资助金额:
$ 44.41万 - 项目类别:
Buprenorphine for probationers and parolees: Bridging the gap into treatment
丁丙诺啡用于缓刑犯和假释犯:缩小治疗差距
- 批准号:
9900629 - 财政年份:2018
- 资助金额:
$ 44.41万 - 项目类别:
Long-acting naltrexone for pre-release prisoners: A randomized trial of mobile treatment
长效纳曲酮用于释放前囚犯:流动治疗的随机试验
- 批准号:
9689961 - 财政年份:2016
- 资助金额:
$ 44.41万 - 项目类别:
Continuing Care App for Probationers and Parolees with Substance Use Disorders
适用于患有药物滥用障碍的缓刑犯和假释犯的持续护理应用程序
- 批准号:
8997778 - 财政年份:2015
- 资助金额:
$ 44.41万 - 项目类别:
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