Long-acting naltrexone for pre-release prisoners: A randomized trial of mobile treatment

长效纳曲酮用于释放前囚犯:流动治疗的随机试验

基本信息

  • 批准号:
    10738933
  • 负责人:
  • 金额:
    $ 44.41万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-05-01 至 2025-04-30
  • 项目状态:
    未结题

项目摘要

Abstract Disorders involving opioid use are a severe problem among jail and prison inmates. Inmates in the US, Canada, Australia, and many European and Asian nations have disproportionately higher rates of opioid use disorders than their general populations. Scarce resources are provided for corrections-based substance use treatment in many nations, and many inmates with OUDs remain untreated. The use of long-acting, injectable naltrexone (XR-NTX) may be a promising form of treatment for pre-release prisoners. Naltrexone blocks the intoxicating and reinforcing effects of opioids, but has no opioid-like effects. This proposed five-year study will focus on whether the addition of providing XR-NTX treatment at a patients’ place of residence will increase adherence and thus efficacy of the medication. Project implementation will occur at five pre-release prisons under the jurisdiction of the Maryland Department of Public Safety and Correctional Services (MDPSCS): 1) Metropolitan Transition Center (MTC) for men; 2) Baltimore Pre-Release Unit (BPRU) for men; 3) Jessup Pre- Release Unit (JPRU) for men; 4) Baltimore City Correctional Center (BCCC) and 5) Maryland Correctional Institution (MCI) for Women. Following initial screening, informed consent, and medical examination, pre- release prisoners at each facility will be block randomized (N=240) within gender to either: Condition 1. XR- NTX-OTx (n=120): One injection of XR-NTX in prison, followed by six monthly injections post-release in the community at an opioid treatment program; or Condition 2. XR-NTX+MMTx (n=120): One injection of XR-NTX in prison, followed by six monthly injections post-release in the community at the patient’s place of residence. All participants will be confirmed opiate-free by urine test and negative naloxone and oral naltrexone tests, and evaluated monthly for seven months and 12 months after release from prison. The proposed study has two specific aims: Aim1. To compare the two study conditions in terms of: a) XR-NTX treatment adherence; b) opioid use; c) criminal activity; d) re-arrest; e) re-incarceration; and f) HIV risk-behaviors (i. needle use; ii. risky sexual behaviors). Aim 2. To determine if the number of months of post-release XR-NTX treatment is related to outcome (a-f above), and if so, is there a point at which XR-NTX v. Non-XR-NTX equilibrates? This would help determine the number of injections, important because of XR-NTX cost. Many individuals in the criminal justice system drop out of treatment and therefore increasing ways to improve adherence by attempting to: 1) expand capacity; and 2) implement access by providing treatment at their place of residence may positively impact outcomes.
摘要

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A clinical protocol of a comparative effectiveness trial of extended-release naltrexone versus extended-release buprenorphine with individuals leaving jail.
  • DOI:
    10.1016/j.jsat.2020.108241
  • 发表时间:
    2021-09
  • 期刊:
  • 影响因子:
    3.9
  • 作者:
    Gordon MS;Mitchell SG;Blue TR;Vocci FJ;Fishman MJ;Murphy SM;Couvillion K;Maher K;Ryan D;Wenzel K;Danner ML;Jarvis DK
  • 通讯作者:
    Jarvis DK
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Michael Scott Gordon其他文献

Michael Scott Gordon的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Michael Scott Gordon', 18)}}的其他基金

A comparative effectiveness trial of extended release naltrexone versus extended-release buprenorphine with individuals leaving jail
缓释纳曲酮与缓释丁丙诺啡对出狱人员的效果比较试验
  • 批准号:
    10160255
  • 财政年份:
    2019
  • 资助金额:
    $ 44.41万
  • 项目类别:
A comparison of Sublingual and Extended-Release Buprenorphine for Individuals Leaving Jail
舌下含服和缓释丁丙诺啡对出狱人员的比较
  • 批准号:
    10547922
  • 财政年份:
    2019
  • 资助金额:
    $ 44.41万
  • 项目类别:
A comparative effectiveness trial of extended release naltrexone versus extended-release buprenorphine with individuals leaving jail
缓释纳曲酮与缓释丁丙诺啡对出狱人员的效果比较试验
  • 批准号:
    10616501
  • 财政年份:
    2019
  • 资助金额:
    $ 44.41万
  • 项目类别:
A comparative effectiveness trial of extended release naltrexone versus extended-release buprenorphine with individuals leaving jail
缓释纳曲酮与缓释丁丙诺啡对出狱人员的效果比较试验
  • 批准号:
    9978020
  • 财政年份:
    2019
  • 资助金额:
    $ 44.41万
  • 项目类别:
A comparative effectiveness trial of extended release naltrexone versus extended-release buprenorphine with individuals leaving jail
缓释纳曲酮与缓释丁丙诺啡对出狱人员的效果比较试验
  • 批准号:
    10388285
  • 财政年份:
    2019
  • 资助金额:
    $ 44.41万
  • 项目类别:
Buprenorphine for probationers and parolees: Bridging the gap into treatment
丁丙诺啡用于缓刑犯和假释犯:缩小治疗差距
  • 批准号:
    9898338
  • 财政年份:
    2018
  • 资助金额:
    $ 44.41万
  • 项目类别:
Buprenorphine for probationers and parolees: Bridging the gap into treatment
丁丙诺啡用于缓刑犯和假释犯:缩小治疗差距
  • 批准号:
    10610309
  • 财政年份:
    2018
  • 资助金额:
    $ 44.41万
  • 项目类别:
Buprenorphine for probationers and parolees: Bridging the gap into treatment
丁丙诺啡用于缓刑犯和假释犯:缩小治疗差距
  • 批准号:
    9900629
  • 财政年份:
    2018
  • 资助金额:
    $ 44.41万
  • 项目类别:
Long-acting naltrexone for pre-release prisoners: A randomized trial of mobile treatment
长效纳曲酮用于释放前囚犯:流动治疗的随机试验
  • 批准号:
    9689961
  • 财政年份:
    2016
  • 资助金额:
    $ 44.41万
  • 项目类别:
Continuing Care App for Probationers and Parolees with Substance Use Disorders
适用于患有药物滥用障碍的缓刑犯和假释犯的持续护理应用程序
  • 批准号:
    8997778
  • 财政年份:
    2015
  • 资助金额:
    $ 44.41万
  • 项目类别:

相似海外基金

The Asia-Pacific War and International War Mobility: Trans-national/regional history of War Evacuees from the Asian Region to Australia
亚太战争与国际战争流动:从亚洲地区战争撤离到澳大利亚的跨国/地区历史
  • 批准号:
    21K12393
  • 财政年份:
    2021
  • 资助金额:
    $ 44.41万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Reconsidering Asian Images from the Peripheral Interfaces: With Particular Reference to the Representation of the Border Zones in Indonesia and Australia
从周边界面重新思考亚洲形象:特别参考印度尼西亚和澳大利亚边境地区的代表性
  • 批准号:
    17K18533
  • 财政年份:
    2017
  • 资助金额:
    $ 44.41万
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
Australia and Brazil in the Asian Century
亚洲世纪中的澳大利亚和巴西
  • 批准号:
    DP170101782
  • 财政年份:
    2017
  • 资助金额:
    $ 44.41万
  • 项目类别:
    Discovery Projects
Transnational Environmental Campaigns in the Australia-Asian Region
澳大利亚-亚洲地区的跨国环保运动
  • 批准号:
    DP150103454
  • 财政年份:
    2015
  • 资助金额:
    $ 44.41万
  • 项目类别:
    Discovery Projects
Multiculturalism and the Cultural and Social Activities of Asian Migrant Professionals: The Case of Australia
多元文化主义与亚洲专业移民的文化和社会活动:澳大利亚案例
  • 批准号:
    26590095
  • 财政年份:
    2014
  • 资助金额:
    $ 44.41万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
South Asian and East Asian economic integration and Australia: strategies for Asian regional cooperation
南亚和东亚经济一体化与澳大利亚:亚洲区域合作战略
  • 批准号:
    LP0776706
  • 财政年份:
    2008
  • 资助金额:
    $ 44.41万
  • 项目类别:
    Linkage Projects
Being Asian in Australia and the United States: Analysing Ethnic Representations in Visual Arts, Popular Culture, Academia and Community Festivals
在澳大利亚和美国成为亚洲人:分析视觉艺术、流行文化、学术界和社区节日中的种族表现
  • 批准号:
    DP0880038
  • 财政年份:
    2008
  • 资助金额:
    $ 44.41万
  • 项目类别:
    Discovery Projects
Measuring Asian Art's Contribution to Contemporary Culture in Australia
衡量亚洲艺术对澳大利亚当代文化的贡献
  • 批准号:
    LP0775050
  • 财政年份:
    2007
  • 资助金额:
    $ 44.41万
  • 项目类别:
    Linkage Projects
The rapid increase of Asian international students in Australia-Focusing on their impact on the city's globalization-
澳大利亚亚洲国际学生迅速增加-聚焦他们对城市全球化的影响-
  • 批准号:
    18720229
  • 财政年份:
    2006
  • 资助金额:
    $ 44.41万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Political and Social Participation of Asian Migrant Professionals in Australia
澳大利亚亚洲专业移民的政治和社会参与
  • 批准号:
    18402040
  • 财政年份:
    2006
  • 资助金额:
    $ 44.41万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了