Phosphodiesterase 4 mediated pathogenic mechanisms in alcohol associated liver disease

磷酸二酯酶 4 介导的酒精相关性肝病的致病机制

基本信息

批准号：
10738641
负责人：
Leila Gobejishvili
金额：
$ 5.21万
依托单位：
UNIVERSITY OF LOUISVILLE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-22 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10738641
关键词：
ADD-1 protein Accounting Affect Alcoholic Liver Diseases Alcohols Applications Grants Architecture Autocrine Communication CYP2E1 gene Cells Cessation of life Cholestasis Cirrhosis Development Disease Epigenetic Process Ethanol Metabolism Extracellular Matrix Proteins FDA approved Faculty Fatty Liver Fibrosis Funding Goals Grant H19 gene Hepatic Hepatic Stellate Cell Hepatocyte In Vitro Individual Knock-out Knockout Mice Knowledge Lead Life Liver Liver Cirrhosis Liver Failure Liver Fibrosis Liver Regeneration Liver diseases Mediating Mentors Messenger RNA Mus Myofibroblast Nutritional Support Organ Paper Paracrine Communication Pathogenicity Patients Physiology Population Process Publishing Regulation Research Research Training Role Steatohepatitis Time Training United States Universities Untranslated RNA Wild Type Mouse alcohol exposure alcohol research career career development cell type chronic liver injury exosome experimental study field study healing hepatocyte injury in vivo lipid biosynthesis lipid metabolism liver injury liver transplantation medical schools meetings mortality mouse model parent grant pharmacologic phosphodiesterase IV professor public health relevance skills

项目摘要

PROJECT SUMMARY This is a proposal for a Diversity Supplement for an assistant professor in University of Louisville School of Medicine to enhance research training and career development in a new field of alcohol associated liver disease (ALD). The parent grant for this proposed supplement examines phosphodiesterase 4 mediated pathogenic mechanisms contributing to the development of alcohol induced hepatic steatosis and injury. The proposed supplement project examines the cross talk between hepatocytes and hepatic stellate cells (HSC) via exosomes in the development of ALD fibrosis. Dr. Gobejishvili (PI of the parent grant), Dr. McClain (mentor, Director of Alcohol Research Center at UofL) and Dr. Montoya-Durango developed new specific aims, which are related to Aim 2 of the parent grant. Dr. Montoya-Durango will share his expertise in exosome research and epigenetics with our research team. This diversity supplement will allow Dr. Montoya-Durango to enhance his skills and knowledge in a new field of study. During the Diversity Supplement period, he will: (1) actively participate in experiments outlined in the proposal, (2) publish at least 3 lead papers, (3) present at the RSA and AASLD meetings, (4) receive regular individual mentoring on training progress and career goals, and (5) submit grant applications.

项目摘要这是针对大学助理教授的多样性补充的提议路易斯维尔医学院，以增强新的研究培训和职业发展酒精相关肝病的领域（ALD）。拟议补充的父母赠款检查磷酸二酯酶4介导的致病机制，有助于酒精的发展诱导肝脂肪变性和损伤。拟议的补充项目通过外泌体检查肝细胞和肝星状细胞（HSC）之间的串扰 ALD纤维化的发展。 Gobejishvili博士（父母赠款的PI），McClain博士（导师， UOFL酒精研究中心主任）和Montoya-Durango博士开发了新的特定特定目的，与父母赠款的目标2有关。蒙托亚·杜兰戈博士将分享他的我们的研究团队在外部研究和表观遗传学方面的专业知识。这种多样性补充剂将使蒙托亚·杜兰戈（Montoya-Durango）博士在新领域增强他的技能和知识研究。在多样性补充期间，他将：（1）积极参与实验提案中概述了（2）在RSA和AASLD上发表至少3篇主要论文，（3）会议，（4）定期接受有关培训进度和职业目标的个人指导，以及（5）提交赠款申请。