Phosphodiesterase 4 mediated pathogenic mechanisms in alcohol associated liver disease

磷酸二酯酶 4 介导的酒精相关性肝病的致病机制

• 批准号: 10738641
• 负责人: Leila Gobejishvili
• 金额: $ 5.21万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-22 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10738641
• 关键词: ADD-1 protein; Accounting; Affect; Alcoholic Liver Diseases; Alcohols; Applications Grants; Architecture; Autocrine Communication; CYP2E1 gene; Cells; Cessation of life; Cholestasis; Cirrhosis; Development; Disease; Epigenetic Process; Ethanol Metabolism; Extracellular Matrix Proteins; FDA approved; Faculty; Fatty Liver; Fibrosis; Funding; Goals; Grant; H19 gene; Hepatic; Hepatic Stellate Cell; Hepatocyte; In Vitro; Individual; Knock-out; Knockout Mice; Knowledge; Lead; Life; Liver; Liver Cirrhosis; Liver Failure; Liver Fibrosis; Liver Regeneration; Liver diseases; Mediating; Mentors; Messenger RNA; Mus; Myofibroblast; Nutritional Support; Organ; Paper; Paracrine Communication; Pathogenicity; Patients; Physiology; Population; Process; Publishing; Regulation; Research; Research Training; Role; Steatohepatitis; Time; Training; United States; Universities; Untranslated RNA; Wild Type Mouse; alcohol exposure; alcohol research; career; career development; cell type; chronic liver injury; exosome; experimental study; field study; healing; hepatocyte injury; in vivo; lipid biosynthesis; lipid metabolism; liver injury; liver transplantation; medical schools; meetings; mortality; mouse model; parent grant; pharmacologic; phosphodiesterase IV; professor; public health relevance; skills

PROJECT SUMMARY This is a proposal for a Diversity Supplement for an assistant professor in University of Louisville School of Medicine to enhance research training and career development in a new field of alcohol associated liver disease (ALD). The parent grant for this proposed supplement examines phosphodiesterase 4 mediated pathogenic mechanisms contributing to the development of alcohol induced hepatic steatosis and injury. The proposed supplement project examines the cross talk between hepatocytes and hepatic stellate cells (HSC) via exosomes in the development of ALD fibrosis. Dr. Gobejishvili (PI of the parent grant), Dr. McClain (mentor, Director of Alcohol Research Center at UofL) and Dr. Montoya-Durango developed new specific aims, which are related to Aim 2 of the parent grant. Dr. Montoya-Durango will share his expertise in exosome research and epigenetics with our research team. This diversity supplement will allow Dr. Montoya-Durango to enhance his skills and knowledge in a new field of study. During the Diversity Supplement period, he will: (1) actively participate in experiments outlined in the proposal, (2) publish at least 3 lead papers, (3) present at the RSA and AASLD meetings, (4) receive regular individual mentoring on training progress and career goals, and (5) submit grant applications.

项目摘要 这是一个多样性补充的建议，在大学的助理教授， 路易斯维尔医学院，以加强研究培训和职业发展的新 酒精相关性肝病（ALD）这项拟议补充的家长补助金 研究磷酸二酯酶4介导的致病机制， 酒精诱导的肝脏脂肪变性和损伤的发展。拟议的补充项目 研究了肝细胞和肝星状细胞（HSC）之间通过外来体的串扰， ALD纤维化的发展。Gobejishvili博士（父母补助金的PI），McClain博士（导师， UofL酒精研究中心主任）和蒙托亚-杜兰戈博士开发了新的特异性 目标，与母公司补助金的目标2有关。蒙托亚-杜兰戈博士将分享他的 我们的研究团队在外泌体研究和表观遗传学方面的专业知识。这种多样性 补助金将使蒙托亚-杜兰戈博士在一个新领域提高他的技能和知识 学习。在多样性补充期间，他将：（1）积极参与实验 提案中概述的内容，（2）至少发表3篇主要论文，（3）出席RSA和AASLD 会议，（4）定期接受有关培训进展和职业目标的个人指导，以及（5） 提交资助申请。