Phosphodiesterase 4 mediated pathogenic mechanisms in alcohol associated liver disease

项目总结 这是一份为加州大学一名助理教授提供的多样性补充方案 路易斯维尔医学院将加强研究、培训和职业发展 酒精相关性肝病(ALD)领域。这项拟议补助金的家长补助金 研究磷酸二酯酶4介导的致病机制 酒精性肝脂肪变性和损伤的发生。拟议的补充项目 研究了肝细胞和肝星状细胞(HSC)之间通过Exosome在 酒精性肝病纤维化的发展。Gobejishvili博士(家长助学金)，McClain博士(导师， UofL酒精研究中心主任)和蒙托亚-杜兰戈博士开发了新的特效药 目标，这与父母赠款的目标2有关。蒙托亚-杜兰戈博士将分享他的 我们的研究团队在外显体研究和表观遗传学方面拥有专业知识。这种多样性 补充剂将使蒙托亚-杜兰戈博士在一个新领域提高技能和知识 在学习方面。在多样性补充期间，他将：(1)积极参与实验 在提案中概述，(2)发表至少3篇主要论文，(3)在RSA和AASLD上发表 会议，(4)定期接受关于培训进展和职业目标的个人指导，以及(5) 提交拨款申请。

PROJECT SUMMARY This is a proposal for a Diversity Supplement for an assistant professor in University of Louisville School of Medicine to enhance research training and career development in a new field of alcohol associated liver disease (ALD). The parent grant for this proposed supplement examines phosphodiesterase 4 mediated pathogenic mechanisms contributing to the development of alcohol induced hepatic steatosis and injury. The proposed supplement project examines the cross talk between hepatocytes and hepatic stellate cells (HSC) via exosomes in the development of ALD fibrosis. Dr. Gobejishvili (PI of the parent grant), Dr. McClain (mentor, Director of Alcohol Research Center at UofL) and Dr. Montoya-Durango developed new specific aims, which are related to Aim 2 of the parent grant. Dr. Montoya-Durango will share his expertise in exosome research and epigenetics with our research team. This diversity supplement will allow Dr. Montoya-Durango to enhance his skills and knowledge in a new field of study. During the Diversity Supplement period, he will: (1) actively participate in experiments outlined in the proposal, (2) publish at least 3 lead papers, (3) present at the RSA and AASLD meetings, (4) receive regular individual mentoring on training progress and career goals, and (5) submit grant applications.