MENTORING IN PATIENT-ORIENTED RESEARCH IN DEEP PHENOTYPING IN CARDIO-ONCOLOGY

项目摘要 这是一个K24指导奖的申请，以病人为导向的研究（POR）从邦妮基，医学博士， 医学科学院的创始人，宾夕法尼亚大学佩雷尔曼医学院的副教授， 宾夕法尼亚Ky博士的长期目标是领导临床科学，揭示可操作的知识， 改善癌症患者和幸存者的心血管护理。这涉及到发展一种深刻的- 表型分析方法，通过对患者的详细评估确定个体患者风险 临床特征、生物标志物和超声心动图衍生的心肌力学指标， 职能，并制定创新战略，以减轻风险。这位候选人的履历很好 导师，研究生产力，项目建设和领导在心脏肿瘤学。这个职业生涯中期 发展奖是至关重要的，让她有必要的保护时间，以进一步提高她的指导技能 在培训早期职业研究人员和医生科学家在心脏肿瘤学，并发展新的技能， 生物医学信息学、健康的社会决定因素（SDOH）和医疗保健差异。科学目标 该提案的目的是通过详细分析种族不平等对心脏肿瘤学的影响， 来自宾夕法尼亚大学卫生系统的电子病历（EMR）的患者水平数据。 这种按种族对SDOH进行的全面研究将在以下方面提供新的机会：1）详细的方法学 生物医学信息学，基于EMR的研究，数据科学，自然语言处理，研究 设计和分析; 2）对SDOH和医疗保健差异有更多的经验和理解， 涉及心脏肿瘤学。几乎没有数据，因为它涉及心脏肿瘤学的差异，这是一个高度 新增长的重要领域。指导目标是培训和支持下一代多样化的 心脏肿瘤学的医生科学家职业发展目标是进一步支持和发展 候选人的专业发展，SDOH科学和生物医学信息学的教育，作为导师的技能 和领导者，以及心脏肿瘤学的项目建设技能。临床和研究的机构环境 宾夕法尼亚大学的翻译POR非常出色。宾夕法尼亚大学医学部已经做了大量的 致力于候选人的持续成功，作为一个以病人为导向的研究人员负责 当前和未来的培训医生科学家在心脏肿瘤POR。一个高素质的指导团队， 合作者团队由SDOH科学、癌症临床试验、医疗保健差异 心血管科学，生物医学信息学，基于EMR的研究和自然语言处理，以及 先进的统计方法将与Ky博士密切合作。他们将共同确保这一提议的成功 以及Ky博士作为POR下一代心脏肿瘤学医生科学家的导师。

PROJECT SUMMARY This is an application for a K24 mentoring award for patient-oriented research (POR) from Bonnie Ky, MD, MSCE, the Founders Associate Professor of Medicine at the Perelman School of Medicine at the University of Pennsylvania. Dr. Ky’s long-term goals are to lead clinical science that will uncover actionable knowledge to improve the cardiovascular care of cancer patients and survivors. This has involved developing a deep- phenotyping approach in which individual patient risk is determined through detailed assessment of patient clinical characteristics, biologic markers, and echocardiography-derived measures of myocardial mechanics and function, and the development of innovative strategies to mitigate risk. The candidate has a strong track record of mentorship, research productivity, program building, and leadership in cardio-oncology. This mid-career development award is critical to allow her the necessary protected time to further augment her mentoring skills in the training of early career researchers and physician scientists in cardio-oncology, and develop new skills in biomedical informatics, the social determinants of health (SDOH), and healthcare disparities. The scientific goals of the proposal are to define the impact of racial inequities in cardio-oncology through a detailed analysis of patient-level data from the electronic medical records (EMR) of the University of Pennsylvania Health System. This comprehensive study of the SDOH by race will offer new opportunities in: 1) detailed methodologic experience in biomedical informatics, EMR-based research, data science, natural language processing, study design, and analytics; 2) greater experience and understanding of the SDOH and healthcare disparities as it relates to cardio-oncology. There are little data as it relates to cardio-oncology disparities, and this is a highly significant area of new growth. The mentoring goals are to train and support the next generation of diverse physician scientists in cardio-oncology POR. The career development goals are to further support and grow the candidate’s professional development, education in SDOH science and biomedical informatics, skills as a mentor and leader, and program building skills in cardio-oncology. The institutional environment for clinical and translational POR at Penn is outstanding. The Department of Medicine at Penn has made a substantial commitment toward the candidate’s continued success as a patient-oriented researcher responsible for the current and future training physician scientists in cardio-oncology POR. A highly qualified mentoring team and team of collaborators comprised of experts in SDOH science, cancer clinical trials, healthcare disparities, cardiovascular science, biomedical informatics, EMR-based research and natural language processing, and advanced statistical methods will work closely with Dr. Ky. Together, they will ensure the success of this proposal and of Dr. Ky as a mentor to the next generation of cardio-oncology physician scientists in POR.