MENTORING IN PATIENT-ORIENTED RESEARCH IN DEEP PHENOTYPING IN CARDIO-ONCOLOGY

指导心脏肿瘤学中以患者为导向的深度表型研究

• 批准号: 10745438
• 负责人: Bonnie Ky
• 金额: $ 12.58万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745438
• 关键词: Age Years; Algorithms; Anthracycline; Area; Award; Biological Markers; Black American; Black race; Breast Cancer Patient; Breast Cancer therapy; Cancer Patient; Cancer Survivor; Cardiotoxicity; Cardiovascular system; Cause of Death; Cessation of life; Characteristics; Clinical; Clinical Sciences; Cohort Studies; Collection; Computerized Medical Record; Data; Data Science; Derivation procedure; Development; Disease; Disease Outcome; Disparity; Early Diagnosis; Echocardiography; Education; Ensure; Environment; Equity; Ethnic Origin; Future; Goals; Health; Health Sciences; Health system; Heart failure; Hyperlipidemia; Hypertension; Incidence; Individual; Inequity; Institution; K-Series Research Career Programs; Knowledge; Lead; Leadership; Life Expectancy; Longitudinal cohort study; Malignant Neoplasms; Malignant neoplasm of prostate; Measures; Mechanics; Medicine; Mentors; Mentorship; Metabolic; Methodology; Myocardial; Myocardial Infarction; Natural Language Processing; Oncology; Outcome; Patient risk; Patient-Focused Outcomes; Patients; Pennsylvania; Phenotype; Physicians; Population; Productivity; Prognosis; Prognostic Factor; Prostate Cancer therapy; Qualifying; Race; Radiation therapy; Recording of previous events; Reproducibility; Research; Research Design; Research Personnel; Risk; Risk Factors; Science; Scientist; Sociology; Statistical Methods; Stroke; Sudden Death; Survivors; System; Time; Training; Universities; Woman; Work; androgen deprivation therapy; biomedical informatics; black women; cancer care; cancer clinical trial; cancer prevention; cancer survival; cancer therapy; career; career development; cohort; comorbidity; disorder control; electronic data; ethnic disparity; experience; health care disparity; health difference; health inequalities; hormone therapy; improved; individual patient; innovation; insight; malignant breast neoplasm; medical schools; men; mid-career faculty; mortality; mortality risk; new growth; next generation; patient oriented; patient oriented research; phase III trial; population based; programs; prospective; racial disparity; racial diversity; risk mitigation; skills; social health determinants; social structure; success; targeted treatment; tumor

PROJECT SUMMARY This is an application for a K24 mentoring award for patient-oriented research (POR) from Bonnie Ky, MD, MSCE, the Founders Associate Professor of Medicine at the Perelman School of Medicine at the University of Pennsylvania. Dr. Ky’s long-term goals are to lead clinical science that will uncover actionable knowledge to improve the cardiovascular care of cancer patients and survivors. This has involved developing a deep- phenotyping approach in which individual patient risk is determined through detailed assessment of patient clinical characteristics, biologic markers, and echocardiography-derived measures of myocardial mechanics and function, and the development of innovative strategies to mitigate risk. The candidate has a strong track record of mentorship, research productivity, program building, and leadership in cardio-oncology. This mid-career development award is critical to allow her the necessary protected time to further augment her mentoring skills in the training of early career researchers and physician scientists in cardio-oncology, and develop new skills in biomedical informatics, the social determinants of health (SDOH), and healthcare disparities. The scientific goals of the proposal are to define the impact of racial inequities in cardio-oncology through a detailed analysis of patient-level data from the electronic medical records (EMR) of the University of Pennsylvania Health System. This comprehensive study of the SDOH by race will offer new opportunities in: 1) detailed methodologic experience in biomedical informatics, EMR-based research, data science, natural language processing, study design, and analytics; 2) greater experience and understanding of the SDOH and healthcare disparities as it relates to cardio-oncology. There are little data as it relates to cardio-oncology disparities, and this is a highly significant area of new growth. The mentoring goals are to train and support the next generation of diverse physician scientists in cardio-oncology POR. The career development goals are to further support and grow the candidate’s professional development, education in SDOH science and biomedical informatics, skills as a mentor and leader, and program building skills in cardio-oncology. The institutional environment for clinical and translational POR at Penn is outstanding. The Department of Medicine at Penn has made a substantial commitment toward the candidate’s continued success as a patient-oriented researcher responsible for the current and future training physician scientists in cardio-oncology POR. A highly qualified mentoring team and team of collaborators comprised of experts in SDOH science, cancer clinical trials, healthcare disparities, cardiovascular science, biomedical informatics, EMR-based research and natural language processing, and advanced statistical methods will work closely with Dr. Ky. Together, they will ensure the success of this proposal and of Dr. Ky as a mentor to the next generation of cardio-oncology physician scientists in POR.

项目摘要 这是Bonnie KY，医学博士的K24心理研究（POR）的申请 MSCE，大学医学院的创始人医学副教授 宾夕法尼亚州。 KY博士的长期目标是领导临床科学，以发现可行的知识 改善癌症患者和幸存者的心血管护理。这涉及开发一个深层 通过详细评估患者确定单个患者风险的表型方法 临床特征，生物标记和超声心动图衍生的心肌力学测量 功能以及制定降低风险的创新策略。候选人有很强的记录 心态，研究生产力，计划建设和心脏肿瘤学领导力的掌握。这个中期 开发奖对于让她提供必要的受保护时间以进一步增强自己的心理技能至关重要 在培训早期职业研究人员和心脏肿瘤学的身体科学家中，并发展了新的技能 生物医学信息，卫生社会决定者（SDOH）和医疗保健差异。科学目标 该提案的旨在通过详细分析来确定种族不平等在心脏肿瘤中的影响 宾夕法尼亚大学卫生系统电子病历（EMR）的患者级数据。 这项对SDOH对种族的全面研究将提供新的机会：1）详细的方法论 具有生物医学信息的经验，基于EMR的研究，数据科学，自然语言处理，研究 设计和分析； 2）对SDOH和医疗保健分配的更大经验和理解 与心脏肿瘤有关。与心脏肿瘤分布有关的数据很少，这是一个高度的数据 新增长的重要领域。心理目标是训练和支持下一代潜水员 心脏肿瘤学的医师科学家。职业发展目标是进一步支持和发展 候选人的专业发展，SDOH科学和生物医学信息的教育，精神的技能 和领导者以及心脏肿瘤学方面的计划建设技能。临床和 宾夕法尼亚州的翻译很出色。宾夕法尼亚州医学系做出了实质性的 致力于候选人作为一名以患者为导向的研究人员的持续成功的承诺 心脏肿瘤学的当前和未来培训物理科学家。一个高素质的心理团队， 合作者团队完成了SDOH科学，癌症临床试验，医疗保健分销专家的完成， 心血管科学，生物医学信息，基于EMR的研究和自然语言处理以及 高级统计方法将与KY博士紧密合作。他们将确保该提案的成功 KY博士是POR中下一代心脏肿瘤物理科学家的心态。