MENTORING IN PATIENT-ORIENTED RESEARCH IN DEEP PHENOTYPING IN CARDIO-ONCOLOGY

指导心脏肿瘤学中以患者为导向的深度表型研究

• 批准号: 10745438
• 负责人: Bonnie Ky
• 金额: $ 12.58万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10745438
• 关键词: Age Years; Algorithms; Anthracycline; Area; Award; Biological Markers; Black American; Black race; Breast Cancer Patient; Breast Cancer therapy; Cancer Patient; Cancer Survivor; Cardiotoxicity; Cardiovascular system; Cause of Death; Cessation of life; Characteristics; Clinical; Clinical Sciences; Cohort Studies; Collection; Computerized Medical Record; Data; Data Science; Derivation procedure; Development; Disease; Disease Outcome; Disparity; Early Diagnosis; Echocardiography; Education; Ensure; Environment; Equity; Ethnic Origin; Future; Goals; Health; Health Sciences; Health system; Heart failure; Hyperlipidemia; Hypertension; Incidence; Individual; Inequity; Institution; K-Series Research Career Programs; Knowledge; Lead; Leadership; Life Expectancy; Longitudinal cohort study; Malignant Neoplasms; Malignant neoplasm of prostate; Measures; Mechanics; Medicine; Mentors; Mentorship; Metabolic; Methodology; Myocardial; Myocardial Infarction; Natural Language Processing; Oncology; Outcome; Patient risk; Patient-Focused Outcomes; Patients; Pennsylvania; Phenotype; Physicians; Population; Productivity; Prognosis; Prognostic Factor; Prostate Cancer therapy; Qualifying; Race; Radiation therapy; Recording of previous events; Reproducibility; Research; Research Design; Research Personnel; Risk; Risk Factors; Science; Scientist; Sociology; Statistical Methods; Stroke; Sudden Death; Survivors; System; Time; Training; Universities; Woman; Work; androgen deprivation therapy; biomedical informatics; black women; cancer care; cancer clinical trial; cancer prevention; cancer survival; cancer therapy; career; career development; cohort; comorbidity; disorder control; electronic data; ethnic disparity; experience; health care disparity; health difference; health inequalities; hormone therapy; improved; individual patient; innovation; insight; malignant breast neoplasm; medical schools; men; mid-career faculty; mortality; mortality risk; new growth; next generation; patient oriented; patient oriented research; phase III trial; population based; programs; prospective; racial disparity; racial diversity; risk mitigation; skills; social health determinants; social structure; success; targeted treatment; tumor

PROJECT SUMMARY This is an application for a K24 mentoring award for patient-oriented research (POR) from Bonnie Ky, MD, MSCE, the Founders Associate Professor of Medicine at the Perelman School of Medicine at the University of Pennsylvania. Dr. Ky’s long-term goals are to lead clinical science that will uncover actionable knowledge to improve the cardiovascular care of cancer patients and survivors. This has involved developing a deep- phenotyping approach in which individual patient risk is determined through detailed assessment of patient clinical characteristics, biologic markers, and echocardiography-derived measures of myocardial mechanics and function, and the development of innovative strategies to mitigate risk. The candidate has a strong track record of mentorship, research productivity, program building, and leadership in cardio-oncology. This mid-career development award is critical to allow her the necessary protected time to further augment her mentoring skills in the training of early career researchers and physician scientists in cardio-oncology, and develop new skills in biomedical informatics, the social determinants of health (SDOH), and healthcare disparities. The scientific goals of the proposal are to define the impact of racial inequities in cardio-oncology through a detailed analysis of patient-level data from the electronic medical records (EMR) of the University of Pennsylvania Health System. This comprehensive study of the SDOH by race will offer new opportunities in: 1) detailed methodologic experience in biomedical informatics, EMR-based research, data science, natural language processing, study design, and analytics; 2) greater experience and understanding of the SDOH and healthcare disparities as it relates to cardio-oncology. There are little data as it relates to cardio-oncology disparities, and this is a highly significant area of new growth. The mentoring goals are to train and support the next generation of diverse physician scientists in cardio-oncology POR. The career development goals are to further support and grow the candidate’s professional development, education in SDOH science and biomedical informatics, skills as a mentor and leader, and program building skills in cardio-oncology. The institutional environment for clinical and translational POR at Penn is outstanding. The Department of Medicine at Penn has made a substantial commitment toward the candidate’s continued success as a patient-oriented researcher responsible for the current and future training physician scientists in cardio-oncology POR. A highly qualified mentoring team and team of collaborators comprised of experts in SDOH science, cancer clinical trials, healthcare disparities, cardiovascular science, biomedical informatics, EMR-based research and natural language processing, and advanced statistical methods will work closely with Dr. Ky. Together, they will ensure the success of this proposal and of Dr. Ky as a mentor to the next generation of cardio-oncology physician scientists in POR.

项目总结 这是来自医学博士Bonnie Ky的以患者为中心的研究(POR)K24指导奖的申请书。 明尼苏达大学佩雷尔曼医学院医学创建者副教授 宾夕法尼亚州。Ky博士的长期目标是引领临床科学发现可操作的知识 改善癌症患者和幸存者的心血管护理。这涉及到开发一种深度- 通过对患者的详细评估来确定单个患者风险的表型方法 临床特征、生物标志物和超声心动图测量心肌力学和 功能，以及制定减少风险的创新战略。这位候选人有很好的履历 在心脏肿瘤学方面的指导、研究效率、项目建设和领导力。这个职业生涯的中期 发展奖是让她有必要的保护时间来进一步增强她的指导技能的关键 在心脏肿瘤学的早期职业研究人员和内科科学家的培训中，并开发新的技能 生物医学信息学、健康的社会决定因素(SDOH)和医疗保健差异。科学目标 该提案的目的是通过对以下方面的详细分析来界定心脏肿瘤学中种族不平等的影响 来自宾夕法尼亚大学健康系统电子病历(EMR)的患者级别数据。 通过种族对SDOH的全面研究将在以下方面提供新的机会：1)详细的方法学 具有生物医学信息学、基于电子病历的研究、数据科学、自然语言处理、研究经验 设计和分析；2)更好地体验和了解SDOH和医疗保健方面的差距 与心脏肿瘤学有关。由于它与心脏肿瘤学的差异有关，所以几乎没有数据，这是一个高度 新增长的重要领域。指导的目标是培养和支持下一代多样化的 心脏肿瘤学方面的内科科学家。职业发展目标是进一步支持和发展 应聘者的职业发展，SDOH科学和生物医学信息学方面的教育，作为导师的技能 心脏肿瘤学方面的领导和项目建设技能。临床和医疗服务的制度环境 宾夕法尼亚州立大学的翻译POR非常出色。宾夕法尼亚大学医学部已经做出了实质性的 致力于让候选人作为一名以患者为中心的研究人员继续取得成功 目前和未来在心脏肿瘤学方面培训内科科学家。一支高素质的指导团队和 合作团队由SDOH科学、癌症临床试验、医疗保健差异、 心血管科学、生物医学信息学、基于电子病历的研究和自然语言处理，以及 先进的统计方法将与Ky博士密切合作。他们将共同确保这项提议的成功。 以及Ky博士作为POR下一代心脏肿瘤内科科学家的导师。