VS4A: VITAL Start (Video-Intervention to Inspire Treatment Adherence for Life) for Adolescents, a video intervention to improve retention and adherence to ART among adolescents living with HIV

VS4A:针对青少年的 VITAL Start(激发终生治疗依从性的视频干预),一种视频干预措施,旨在提高艾滋病毒感染青少年对 ART 的保留和依从性

基本信息

  • 批准号:
    10749263
  • 负责人:
  • 金额:
    $ 117.67万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-09-24 至 2028-05-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT The 1.7 million adolescents living with HIV (ALHIV) globally urgently need interventions to help improve retention, adherence, and ultimately viral load suppression (VLS). With both high rates of incident infection and some of the lowest VLS rates, ALHIV experience high mortality with approximately 100 deaths per day. Successful interventions to improve retention and VLS among ALHIV in low- and middle-income countries (LMIC) remain limited. Video-based interventions that provide counseling to patients living with HIV have increased patient HIV knowledge, supported disclosure, fostered behavior change, and improved treatment adherence. Targeted messaging can be woven into culturally relevant films with engaging storylines and delivered at critical teachable moments. Films can be shown in high-volume clinics to deliver standardized counseling content while freeing up HCW time. While video-based interventions have the potential to address barriers to ALHIV ART retention and adherence, they are not commonly used throughout Sub-Saharan Africa (SSA). Our team was one of the first to pilot and study the impact of a video-based intervention on HIV service delivery; preliminary results have suggested high levels of patient and HCW satisfaction, improved ART knowledge, adherence, and retention. Based on these promising results, we propose to adapt, assess and support scale up of a tailored, video-based counseling package for ALHIV: VITAL (Video Intervention to Inspire Treatment Adherence for Life) Start for Adolescents (VS4A). Our study will examine the impact of VS4A on the primary composite outcome of retention and adherence (viral load <1000 copies/ml) in a multisite two-arm cluster randomized controlled trial (CRCT) with 1:1 randomization in Malawi. Our overall hypothesis is that VS4A will a) achieve broad reach, b) be acceptable and feasible to implement, c) improve adolescent VLS and several secondary outcomes; and d) be cost-effective at scale. If effective, VS4A can be an innovative, scalable tool to improve service delivery for ALHIV while also liberating HCW time and reducing health system burden in Malawi. Building on a 15-year partnership with the Malawi Ministry of Health (MOH), a track record of excellence and innovation in service to ALHIV, and a robust implementation science research portfolio, our team is poised to successfully implement the VS4A study and program and to use findings to support rapid, wide-scale dissemination and scale up.
项目总结/摘要 全球170万艾滋病毒感染者(ALHIV)迫切需要干预措施,以帮助改善 保留、粘附和最终的病毒载量抑制(VLS)。在高感染率的情况下, 和一些最低的VLS率,ALHIV经历高死亡率,每天约100例死亡。 在低收入和中等收入国家采取成功干预措施,提高艾滋病毒/艾滋病患者的保留率和VLS (LMIC)仍然有限。为艾滋病毒感染者提供咨询的基于视频的干预措施 增加患者的艾滋病毒知识,支持披露,促进行为改变和改善治疗 坚持。有针对性的信息可以编织到具有吸引人的故事情节的文化相关电影中, 在关键的可教时刻提供。可以在高容量诊所放映电影,以提供标准化的 咨询内容,同时腾出HCW时间。虽然视频干预有可能解决 ALHIV ART保留和坚持的障碍,它们在撒哈拉以南非洲地区并不普遍使用 (SSA)。我们的团队是首批试点和研究基于视频的艾滋病毒服务干预影响的团队之一 交付;初步结果表明患者和HCW满意度高,ART改善 知识、坚持和保留。基于这些有希望的结果,我们建议调整,评估和 支持扩大为艾滋病毒/艾滋病专门制作的视频咨询包:VITAL(对艾滋病毒的视频干预) 终身治疗依从性)开始青少年(VS 4A)。我们的研究将检查VS 4A对 在一个多中心双臂研究中,保留和粘附(病毒载量<1000拷贝/ml)的主要复合结果 在马拉维进行的1:1随机分组的随机对照试验(CRCT)。我们的总体假设是 VS 4A将a)实现广泛覆盖,B)可接受且可行,c)改善青少年 VLS和几个次要结果;以及d)在规模上具有成本效益。如果有效,VS 4A可以是一个 创新、可扩展的工具,以改善ALHIV的服务交付,同时还解放了HCW时间, 马拉维卫生系统负担。在与马拉维卫生部15年伙伴关系的基础上, 在为ALHIV服务方面的卓越和创新记录,以及强大的实施科学研究 投资组合,我们的团队准备成功实施VS 4A研究和计划,并利用研究结果, 支持迅速、大规模传播和扩大。

项目成果

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Saeed Ahmed其他文献

Saeed Ahmed的其他文献

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{{ truncateString('Saeed Ahmed', 18)}}的其他基金

VITAL Start (Video-intervention to Inspire Treatment Adherence for Life): Brief facility based video intervention to improve retention and adherence to ART among pregnant and breastfeeding women
VITAL Start(视频干预,以激发终生治疗依从性):基于设施的简短视频干预,以提高孕妇和哺乳期妇女对 ART 的保留和依从性
  • 批准号:
    10335141
  • 财政年份:
    2018
  • 资助金额:
    $ 117.67万
  • 项目类别:

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