Community Engagement Core

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ABSTRACT This proposal for the Community Engagement Core (CEC) for the Pacific Center for Genome Research (PCGR) has a long-term goal to ensure the Center’s consideration of equity and ethics in the examination of genetic and other risk factors across the underserved and ethnic minority groups including Native Hawaiians (NHs), Africans, Latinos, Europeans, and Asians, served by this proposal. Additionally, the CEC will develop resources to support genetic education and training for students, medical providers, and the broader community, including the medically underserved communities identified for investigation. We will work closely with our Genomic Workforce Development Core and the Administrative Core to build a repository of resources for use in various formats to support the Center’s training and educational activities. Additionally, we will hold annual workshops and seminars to build awareness of the implications of genomic research in partnership with the community-based organizations working with these underserved groups. The first aim of the CEC is to Provide clinical and community stakeholder input and oversight for Project 1 objectives to use data from the Population Architecture using the Genomics and Epidemiology Consortium, the Multi-Ethnic Study of Atherosclerosis, the Genetic Epidemiology Network of Arteriopathy, INTERVAL, Atherosclerosis Risk in Communities, UK Biobank, and Framingham Heart Study to develop genetic prediction models to identify causally relevant biomarkers for risks of multiple diseases across African, Latino, Asian, European, and NH groups and understand marker-risk factor interaction effects on disease risks. The second aim is to provide clinical and community stakeholder input and oversight for Project 2 objectives to characterize the genomic landscape, perform epigenomic profiling and identify genomic risk factors for lung cancer in NHs by comparing them with the genomics and epigenomics data from other ethnic groups. The final aim of the CEC is to support student, stakeholder, and community education and awareness of the U54 PCGR. To achieve these aims, the CEC will convene Community Advisory Boards to support the promotion and education about the two U54 PCGR projects among physicians, content experts, and community stakeholders. The CEC will also develop and implement a regular series of community seminars and workshops to disseminate U54 PCGR and external genome research leaders’ scientific findings and identify strategies for implementing risk identification methods in clinical settings. As a result, the CEC will contribute y to the success of the U54 PCGR projects and provide an optimal foundation for future genomic research at the University of Hawaii.