Community Engagement Core

社区参与核心

• 批准号: 10749845
• 负责人: Kevin Darryl Cassel
• 金额: $ 14.48万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10749845
• 关键词: African; Architecture; Arterial Disorder; Asian; Asian population; Atherosclerosis Risk in Communities; Awareness; Biological Markers; Blood; Cancer Burden; Clinical; Communities; Community Health Education; Community Relations; Complex; DNA Methylation; Data; Disease; Education; Educational Activities; Educational workshop; Ensure; Epidemiology; Equity; Ethics; Ethnic Population; European; Focus Groups; Foundations; Framingham Heart Study; Future; Gene Expression; General Population; Genetic; Genome; Genomics; Goals; Hawaii; Infrastructure; Investigation; Latino; Latino Population; Malignant neoplasm of lung; Medical; Methods; Minority Groups; Multi-Ethnic Study of Atherosclerosis; Native Hawaiian; Pacific Islands; Participant; Physicians; Play; Population; Prevention Research; Protocols documentation; Provider; Research; Research Project Grants; Resources; Risk; Risk Factors; Risk Marker; Role; Series; Students; Tissues; Training and Education; Translational Research; Underrepresented Minority; Underserved Population; Universities; Work; Workforce Development; biobank; community engagement; community organizations; disorder prevention; disorder risk; epigenomic profiling; epigenomics; ethnic minority population; experience; genetic epidemiology; genetic predictors; high risk; interest; medically underserved; member; multi-ethnic; non-genetic; predictive modeling; protein expression; public health relevance; recruit; repository; student training; success; underserved community; underserved minority

ABSTRACT This proposal for the Community Engagement Core (CEC) for the Pacific Center for Genome Research (PCGR) has a long-term goal to ensure the Center’s consideration of equity and ethics in the examination of genetic and other risk factors across the underserved and ethnic minority groups including Native Hawaiians (NHs), Africans, Latinos, Europeans, and Asians, served by this proposal. Additionally, the CEC will develop resources to support genetic education and training for students, medical providers, and the broader community, including the medically underserved communities identified for investigation. We will work closely with our Genomic Workforce Development Core and the Administrative Core to build a repository of resources for use in various formats to support the Center’s training and educational activities. Additionally, we will hold annual workshops and seminars to build awareness of the implications of genomic research in partnership with the community-based organizations working with these underserved groups. The first aim of the CEC is to Provide clinical and community stakeholder input and oversight for Project 1 objectives to use data from the Population Architecture using the Genomics and Epidemiology Consortium, the Multi-Ethnic Study of Atherosclerosis, the Genetic Epidemiology Network of Arteriopathy, INTERVAL, Atherosclerosis Risk in Communities, UK Biobank, and Framingham Heart Study to develop genetic prediction models to identify causally relevant biomarkers for risks of multiple diseases across African, Latino, Asian, European, and NH groups and understand marker-risk factor interaction effects on disease risks. The second aim is to provide clinical and community stakeholder input and oversight for Project 2 objectives to characterize the genomic landscape, perform epigenomic profiling and identify genomic risk factors for lung cancer in NHs by comparing them with the genomics and epigenomics data from other ethnic groups. The final aim of the CEC is to support student, stakeholder, and community education and awareness of the U54 PCGR. To achieve these aims, the CEC will convene Community Advisory Boards to support the promotion and education about the two U54 PCGR projects among physicians, content experts, and community stakeholders. The CEC will also develop and implement a regular series of community seminars and workshops to disseminate U54 PCGR and external genome research leaders’ scientific findings and identify strategies for implementing risk identification methods in clinical settings. As a result, the CEC will contribute y to the success of the U54 PCGR projects and provide an optimal foundation for future genomic research at the University of Hawaii.

摘要 太平洋基因组中心的社区参与核心（CEC）提案 研究（PCGR）有一个长期目标，以确保该中心的公平考虑， 在检查遗传和其他风险因素方面的伦理问题， 包括夏威夷原住民、非洲人、拉丁美洲人、欧洲人和亚洲人在内的少数群体， 这一提议所服务的。此外，CEC将开发资源，支持遗传学 为学生、医疗服务提供者和更广泛的社区提供教育和培训，包括 确定进行调查的医疗服务不足社区。我们将与我们的 基因组劳动力发展核心和行政核心，以建立一个知识库， 以各种形式使用的资源，以支持中心的培训和教育活动。 此外，我们将每年举办讲习班和研讨会，以提高对影响的认识 基因组研究与社区组织合作， 弱势群体。CEC的首要目标是为临床和社区利益相关者提供 输入和监督项目1的目标，使用人口结构的数据， 基因组学和流行病学联盟，动脉粥样硬化的多种族研究， 动脉病遗传流行病学网络，间隔，动脉粥样硬化风险， Communities、UK Biobank和Fragrance Heart Study开发遗传预测模型 确定非洲人，拉丁美洲人， 亚洲人、欧洲人和NH人群，并了解标记物-风险因素相互作用对 疾病风险。第二个目标是提供临床和社区利益相关者的投入， 监督项目2的目标，以表征基因组景观，进行表观基因组 分析和识别NHs中肺癌的基因组风险因素， 基因组学和表观基因组学数据。CEC的最终目标是 支持学生，利益相关者和社区教育和U 54 PCGR的认识。到 为了实现这些目标，CEC将召集社区咨询委员会， 在医生、内容专家、 和社区利益相关者。CEC还将制定和实施一系列定期的 社区研讨会和讲习班，以传播U 54 PCGR和外部基因组研究 领导人的科学发现，并确定战略，实施风险识别方法， 临床环境。因此，CEC将为U 54 PCGR项目的成功做出贡献 并为夏威夷大学未来的基因组研究提供最佳基础。