Community Engagement Core

摘要 太平洋基因组中心的社区参与核心(CEC)提案 研究(PCGR)有一个长期目标，以确保中心对公平和 在对服务不足和种族的遗传和其他风险因素进行检查时的伦理 少数群体，包括夏威夷原住民(NHS)、非洲人、拉丁人、欧洲人和亚洲人， 由这项提议所服务。此外，CEC将开发资源来支持遗传 为学生、医疗提供者和更广泛的社区提供教育和培训，包括 被确定为调查对象的医疗服务不足的社区。我们将与我们的 基因组员工发展核心和管理核心，以建立一个信息库 各种形式的资源，用于支持中心的培训和教育活动。 此外，我们将每年举办工作坊和研讨会，以提高人们对这些影响的认识。 与基于社区的组织合作进行的基因组研究 服务不足的群体。CEC的第一个目标是为临床和社区利益相关者提供 输入和监督项目1的目标，以使用人口结构的数据 基因组学和流行病学联合会，动脉粥样硬化的多种族研究， 动脉疾病遗传流行病学网络，间隔，动脉粥样硬化风险 社区、英国生物库和弗雷明翰心脏研究开发遗传预测模型 确定非洲人、拉丁裔人、 亚洲、欧洲和NH组，并了解标记-风险因素交互作用对 疾病风险。第二个目标是提供临床和社区利益相关者的意见和 监督项目2的目标，以描述基因组图景，执行表观基因组学 在NHS中通过比较肺癌的基因组危险因素来描述和识别它们 来自其他民族的基因组学和表观基因组学数据。CEC的最终目标是 支持学生、利益相关者和社区对U54 PCGR的教育和认识。至 为了达到这些目标，行政长官会议将召开社区咨询委员会，支持 对两个U54 PCGR项目进行宣传和教育， 和社区利益相关者。CEC还将制定和实施一系列定期的 社区研讨会和讲习班以传播U54 PCGR和外部基因组研究 领导的科学发现和确定战略，以实施风险识别方法在 临床环境。因此，CEC将为U54 PCGR项目的成功作出贡献 并为夏威夷大学未来的基因组研究提供最佳基础。

ABSTRACT This proposal for the Community Engagement Core (CEC) for the Pacific Center for Genome Research (PCGR) has a long-term goal to ensure the Center’s consideration of equity and ethics in the examination of genetic and other risk factors across the underserved and ethnic minority groups including Native Hawaiians (NHs), Africans, Latinos, Europeans, and Asians, served by this proposal. Additionally, the CEC will develop resources to support genetic education and training for students, medical providers, and the broader community, including the medically underserved communities identified for investigation. We will work closely with our Genomic Workforce Development Core and the Administrative Core to build a repository of resources for use in various formats to support the Center’s training and educational activities. Additionally, we will hold annual workshops and seminars to build awareness of the implications of genomic research in partnership with the community-based organizations working with these underserved groups. The first aim of the CEC is to Provide clinical and community stakeholder input and oversight for Project 1 objectives to use data from the Population Architecture using the Genomics and Epidemiology Consortium, the Multi-Ethnic Study of Atherosclerosis, the Genetic Epidemiology Network of Arteriopathy, INTERVAL, Atherosclerosis Risk in Communities, UK Biobank, and Framingham Heart Study to develop genetic prediction models to identify causally relevant biomarkers for risks of multiple diseases across African, Latino, Asian, European, and NH groups and understand marker-risk factor interaction effects on disease risks. The second aim is to provide clinical and community stakeholder input and oversight for Project 2 objectives to characterize the genomic landscape, perform epigenomic profiling and identify genomic risk factors for lung cancer in NHs by comparing them with the genomics and epigenomics data from other ethnic groups. The final aim of the CEC is to support student, stakeholder, and community education and awareness of the U54 PCGR. To achieve these aims, the CEC will convene Community Advisory Boards to support the promotion and education about the two U54 PCGR projects among physicians, content experts, and community stakeholders. The CEC will also develop and implement a regular series of community seminars and workshops to disseminate U54 PCGR and external genome research leaders’ scientific findings and identify strategies for implementing risk identification methods in clinical settings. As a result, the CEC will contribute y to the success of the U54 PCGR projects and provide an optimal foundation for future genomic research at the University of Hawaii.