Early Phase Pain Investigation Clinical Network Hub at the University of Washington

点击翻译按钮获取中文摘要

PROJECT SUMMARY The concurrent public health crises of opioid misuse with associated overdose death epidemic and inadequate options for pain management require innovative, far-reaching, safe and effective solutions. The University of Washington’s (UW) Division of Pain Medicine (UW Pain) is a Specialized Clinical Center within EPPIC-Net, representing the Pacific Northwest region and beyond. UW Pain (“hub”) includes four core clinical sites: UW Medical Center, Harborview Medical Center, Seattle Children’s Hospital, and Seattle Cancer Care Alliance. The hub is driven by an experienced core team that has leveraged existing infrastructure and resources and identified a flexible, diverse, and robust network of spoke sites to help meet the broad needs of EPPIC-Net. Our team of principal investigators has extensive relevant experience in conducting multi-site clinical trials across all phases and in deep phenotyping, such as behavioral and psychological profiling, quantitative sensory testing, neuroimaging, and biomarker research. The team is further supported by research coordinators and will work closely with UW’s Institute for Translational Health Sciences (ITHS), the site of UW’s Clinical and Translational Science Award. Relevant UW departments affords access to disease-specific expertise and patient populations. Our network spans multiple states and specialties, allowing access to geographically and demographically diverse (including underrepresented and underserved) patient populations and a broad range of medical and surgical disorders for which pain is a clinically significant component. To achieve the goals of the HEAL initiative’s EPPIC-Net, we have: (1) Established UW EPPIC-Net Hub and Spokes infrastructure, provide scientific leadership and administrative oversight, and apply our expertise in design and conduct of high-quality multidisciplinary Phase 2 clinical trials and biomarker validation studies; (2) Developed policies and procedures for rapid design, initiation, recruitment, conduct, and closure of high quality multidisciplinary Phase 2 clinical trials and biomarker validation studies for specific pain conditions at UW Pain EPPIC-Net Hub and Spokes, and; (3) Established mechanisms for communication, education and training, and performance assessment of the UW-EPPIC-Net Hub and Spokes, to assure efficient and timely utilization of resources to most effectively recruit participants.