Administrative Core

抽象--管理核心 行政核心将支持《乳癌前情况图集》的总体目标，即1) 开发一个可查找、可访问、可互操作和可重复使用的平台，用于组织和共享三个- 多维、多模式的乳腺癌前数据有助于发现两者的自然历史 癌症前期和发展为危及生命的癌症的预测因素，以及2)在该平台上填充 来自DCIS患者的回溯性和纵向队列的数据，并展示了其在构建 一份图集，用来测试新的进展预测指标。为此，行政核心将促进行政管理 管理乳腺癌前病变图集，培养图集内的协作和沟通 与其他Htan癌症前中心一样，确保财务和法规合规，并提供一致的 评估和监控，以确保项目的有效进展。这个核心的具体目标是：1) 通过拥有具有补充技能的MPI来提供组织、管理和科学领导 提供可信的研究成功范例，表现出对所有团队成员的尊重和关心，建立 团队认同、文化和凝聚力，培养对创新和卓越的期望，利用制度 以及外部资源，提供建设性的反馈和冲突解决方案，并树立道德榜样 行为；2)通过监督所有人的资金分配和核算来提供行政管理 中心的开支，包括研究单位，并提供文书支助。它还将与 其他PCA和HTA研究中心执行NIH政策，监督质量控制和 产品发布，并确保财务和监管合规；3)促进Breast Pre 癌症图谱中心和跨机构PCA和HTA研究中心，通过利用机构 支持附属NCI指定的综合癌症中心的基础设施并与其密切合作 中心，以确保资源和基础设施的最佳利用，实现规模经济，以及 消除了重叠。行政核心还将帮助规划和协调Htan会议和 电话会议；4)通过确认数据共享和定义来发展能力和监督数据操作 与数据分析股协作制定数据业务的最佳做法，以确保 生成、管理和分析可靠和有效的数据，以确保数据完整性和 研究结果的重现性；5)评估和报告研究进展并确保双向 乳腺癌前地图集中心与其他PCA和Htan中心之间的研究成果交流。

ABSTRACT – Administrative Core The Administrative Core will support the general objectives of the Breast Pre-Cancer Atlas, which are to 1) develop a findable, accessible, interoperable, and reusable platform for organizing and sharing three- dimensional, multi-modal breast pre-cancer data derived that facilitates the discovery of both the natural history of the pre-cancer and predictors of progression to life-threatening cancers, and 2) populate that platform with data from both retrospective and longitudinal cohorts of patients with DCIS and demonstrate its use to construct an atlas to test novel predictors of progression. To do this, the Administrative Core will facilitate administrative management of the Breast Pre-Cancer Atlas, cultivate collaboration and communication within the Atlas as well as with other HTAN Pre-Cancer Centers, ensure fiscal and regulatory compliance, and provide consistent evaluation and monitoring to ensure effective progress of the program. The Specific Aims of this Core will be: 1) To provide organizational, administrative, and scientific leadership by having mPIs with complementing skill sets to provide credible examples of research success, demonstrate respect and concern for all team members, build team identity, culture, and coherence, cultivate expectations of innovation and excellence, leverage institutional as well as extramural resources, provide constructive feedback and conflict resolution, and model ethical behavior; 2) To provide administrative management by overseeing distribution of funds to and accounting for all expenditures in the Center, including Research Units, and provide clerical support. It will also coordinate with other PCA and HTA Research Centers to implement compliance with NIH policies, oversee quality control and product release, and ensure fiscal and regulatory compliance; 3) To promote integration within the Breast Pre- Cancer Atlas Center and across the Institutional PCA and HTA Research Centers by leveraging institutional support and working closely with the infrastructure of the affiliated NCI-designated Comprehensive Cancer Centers to ensure that resources and infrastructure are optimally utilized, economies of scale are realized, and overlaps eliminated. The Administrative Core also will help to plan and coordinate HTAN meetings and teleconferences; 4) To develop capabilities and oversee data operations by confirming data sharing and defining and developing best practices for data operations in collaboration with the Data Analysis Unit to ensure that reliable and valid data are generated, managed, and analyzed in a way that ensures data integrity and reproducibility of research findings; 5) To evaluate and report research progress and to ensure bidirectional exchange of research findings between the Breast Pre-Cancer Atlas Center and other PCA and HTAN Centers.