Administrative Core

摘要-行政核心 行政核心将支持乳腺癌前地图集的总体目标，即： 开发一个可查找、可访问、可互操作和可重用的平台，用于组织和共享三个 三维的，多模态的乳腺癌前数据，有助于发现自然史， 癌前病变和发展为危及生命的癌症的预测因子，以及2）用 来自DCIS患者的回顾性和纵向队列的数据，并证明其用于构建 一个测试新的进展预测指标的图谱。为此，行政核心将促进行政管理 乳腺癌前病变图谱的管理，培养图谱内的合作和沟通，以及 与其他HTAN癌前中心一样，确保财政和监管合规，并提供一致的 评估和监测，以确保方案的有效进展。该核心的具体目标是：1） 通过具有互补技能的mPI提供组织，行政和科学领导 提供可信的研究成功案例，表现出对所有团队成员的尊重和关心， 团队身份、文化和凝聚力，培养创新和卓越的期望，利用机构 以及校外资源，提供建设性的反馈和解决冲突，并建立道德模型 行为; 2）通过监督所有人的资金分配和核算来提供行政管理 支出的中心，包括研究单位，并提供文书支持。它还将与 其他PCA和HTA研究中心实施符合NIH政策，监督质量控制， 产品发布，并确保财政和监管合规性; 3）促进乳腺癌前病变的整合， 癌症地图集中心和整个机构PCA和HTA研究中心，通过利用机构 支持并与附属的NCI-designated综合癌症的基础设施密切合作 中心，以确保资源和基础设施得到最佳利用，实现规模经济， 消除重叠。行政核心还将帮助规划和协调HTAN会议， 电话会议; 4）通过确认数据共享和定义来开发能力和监督数据操作 并与数据分析股合作制定数据操作的最佳做法，以确保 以确保数据完整性的方式生成、管理和分析可靠有效的数据， 研究成果的可重复性; 5）评估和报告研究进展，并确保双向 乳腺癌前病变图谱中心与其他PCA和HTAN中心之间的研究成果交流。

ABSTRACT – Administrative Core The Administrative Core will support the general objectives of the Breast Pre-Cancer Atlas, which are to 1) develop a findable, accessible, interoperable, and reusable platform for organizing and sharing three- dimensional, multi-modal breast pre-cancer data derived that facilitates the discovery of both the natural history of the pre-cancer and predictors of progression to life-threatening cancers, and 2) populate that platform with data from both retrospective and longitudinal cohorts of patients with DCIS and demonstrate its use to construct an atlas to test novel predictors of progression. To do this, the Administrative Core will facilitate administrative management of the Breast Pre-Cancer Atlas, cultivate collaboration and communication within the Atlas as well as with other HTAN Pre-Cancer Centers, ensure fiscal and regulatory compliance, and provide consistent evaluation and monitoring to ensure effective progress of the program. The Specific Aims of this Core will be: 1) To provide organizational, administrative, and scientific leadership by having mPIs with complementing skill sets to provide credible examples of research success, demonstrate respect and concern for all team members, build team identity, culture, and coherence, cultivate expectations of innovation and excellence, leverage institutional as well as extramural resources, provide constructive feedback and conflict resolution, and model ethical behavior; 2) To provide administrative management by overseeing distribution of funds to and accounting for all expenditures in the Center, including Research Units, and provide clerical support. It will also coordinate with other PCA and HTA Research Centers to implement compliance with NIH policies, oversee quality control and product release, and ensure fiscal and regulatory compliance; 3) To promote integration within the Breast Pre- Cancer Atlas Center and across the Institutional PCA and HTA Research Centers by leveraging institutional support and working closely with the infrastructure of the affiliated NCI-designated Comprehensive Cancer Centers to ensure that resources and infrastructure are optimally utilized, economies of scale are realized, and overlaps eliminated. The Administrative Core also will help to plan and coordinate HTAN meetings and teleconferences; 4) To develop capabilities and oversee data operations by confirming data sharing and defining and developing best practices for data operations in collaboration with the Data Analysis Unit to ensure that reliable and valid data are generated, managed, and analyzed in a way that ensures data integrity and reproducibility of research findings; 5) To evaluate and report research progress and to ensure bidirectional exchange of research findings between the Breast Pre-Cancer Atlas Center and other PCA and HTAN Centers.