Medical Student Summer Research Program in Infection and Immunity

医学生感染与免疫暑期研究计划

• 批准号: 10620608
• 负责人: Daniel L Mueller
• 金额: $ 4.71万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10620608
• 关键词: Advisory Committees; Autoimmune Diseases; Career Choice; Employment; Enrollment; Faculty; Financial Support; Funding; Grant; Health; Human; Immunity; Immunology; Individual; Infection; Instruction; Investigation; Laboratories; Lead; Leadership; Longitudinal Surveys; Medical; Medical Research; Medical Students; Medicine; Mentors; Mentorship; Mind; Minnesota; Monitor; Oral; Pathogenesis; Pathway interactions; Perception; Performance; Physicians; Progress Reports; Publishing; Records; Research; Research Personnel; Research Training; Residencies; Rheumatology; Scientist; Students; Surveys; Talents; Teacher Professional Development; Training; Universities; Work; Writing; aspirate; career; direct patient care; experience; immune system function; interest; medical schools; member; posters; pre-doctoral; programs; recruit; success; summer research; summer student; undergraduate student

Project Summary/Abstract The University of Minnesota Medical School is committed to the recruitment, enrollment, research instruction, and mentoring of a diverse group of high-quality medical students with aspirations of a career in academic medicine. Based on surveys of medical students, as well as on an analysis by a faculty-driven Medical Student Research Task Force, we identified research training in the summer between years 1 and 2 as the critical opportunity to capture the interests and talents of academically minded medical students. Thus, this T35 competitive renewal application for a “Medical Student Summer Research Program in Infection and Immunity” represents our plan to continue to provide high quality medical student research instruction and mentorship. Our long-term objective is to significantly increase the number and diversity of medical students that obtain paid employment in medical research, that publish during medical school, and that eventually enter into physician-scientist training pathway residency programs. To this end, we describe herein our activities during the first 5 years of the program (including years 1-4 of this funded T35 grant) and offer the results of our current efforts based on the performance and perceptions of 30 medical student summer researchers. Daniel Mueller, MD, initially developed this Medical Student Summer Research Program in Infection and Immunity, and will continue to lead this T35 training grant. He has a breadth of experience in academic medicine including a) laboratory-based research that includes both fundamental and human-oriented investigation into autoimmune disease pathogenesis, b) medical leadership as a division director, c) an extensive undergraduate and pre-doctoral training record, and d) direct patient care in Rheumatology. Mueller will be assisted by numerous Medical School leaders with records of success in research and mentorship, and will receive additional financial support from the Chair of Medicine and the Dean of the Medical School. A total of 31 outstanding Center for Immunology faculty members will serve as the preceptors for 7 summer medical students in each year of the grant period. Diverse student candidates will be approached by the T35 director on an individual basis, and encouraged to apply to the program. Students entering the program will receive direct instruction in scientific investigation for a period of 2 months. Students will also receive weekly instruction that relates the function of the immune system to human health. Training experiences will include the writing of a formal “Specific Aims Page” proposal, as well as a “Progress Report” final summary of their research. In addition, fellows will prepare and present to Center for Immunology faculty both a scientific poster and oral presentation of their work. Finally, trainees will be given the opportunity for longitudinal mentorship regarding the physician-scientist career path throughout their medical school experience. Success in this program will be monitored both through longitudinal surveys of students and training faculty as well as through oversight by both Internal and External Advisors.

项目总结/摘要 明尼苏达大学医学院致力于招聘，招生，研究指导， 和指导一个多元化的高素质的医学生群体与学术生涯的愿望 药基于对医学生的调查，以及对一个学院驱动的医学生的分析， 研究工作队，我们确定在夏季之间的研究培训1和2的关键 抓住有学术头脑的医学生的兴趣和才能的机会。因此，T35 “医学生感染和免疫夏季研究计划”的竞争性续期申请 代表了我们继续提供高质量医学生研究指导和指导的计划。 我们的长期目标是显着增加医学生的数量和多样性，获得 在医学研究中有报酬的工作，在医学院期间发表，并最终进入 医生-科学家培训途径住院医师计划。为此，我们在此描述我们在 该计划的前5年（包括该资助的T35赠款的第1-4年），并提供我们的结果 根据30名医学生暑期研究人员的表现和看法，目前的努力。丹尼尔 Mueller，MD，最初开发了这个医学生感染和免疫暑期研究项目， 并将继续领导T35培训补助金。他在学术医学方面有广泛的经验 包括a）以实验室为基础的研究，包括基础和以人为本的调查， 自身免疫性疾病发病机制，B）作为部门主管的医学领导，c）广泛的本科生 和博士前培训记录，和d）在流变学的直接病人护理。穆勒将得到以下方面的协助： 许多医学院领导人在研究和指导的成功记录，并将获得 医学主席和医学院院长提供额外的财政支持。共有31 免疫学中心的优秀教师将担任7个夏季医学的导师 学生在每一年的补助金期间。T35主任将接触不同的学生候选人 在个人的基础上，并鼓励申请该计划。进入该计划的学生将获得 直接指导科学调查，为期2个月。学生还将接受每周指导 将免疫系统的功能与人类健康联系起来。培训经验将包括编写 一份正式的“具体目标页”提案，以及一份“进展报告”，对他们的研究进行最后总结。在 此外，研究员将准备并提交给免疫学中心的教师既科学海报和口头 介绍他们的工作。最后，学员将有机会获得以下方面的纵向指导 医生科学家的职业道路在他们的医学院的经验。该计划的成功将是 通过对学生和培训教师的纵向调查以及 内部和外部顾问。

项目成果

Lessons Learned From Conducting Internet-Based Randomized Clinical Trials During a Global Pandemic.

• DOI: 10.1093/ofid/ofaa602
• 发表时间: 2021-03
• 期刊: Open forum infectious diseases
• 影响因子: 4.2
• 作者: Pullen MF;Pastick KA;Williams DA;Nascene AA;Bangdiwala AS;Okafor EC;Hullsiek KH;Skipper CP;Lofgren SM;Engen N;Abassi M;McDonald EG;Lee TC;Rajasingham R;Boulware DR
• 通讯作者: Boulware DR

Combination PD-1 and PD-L1 Blockade Promotes Durable Neoantigen-Specific T Cell-Mediated Immunity in Pancreatic Ductal Adenocarcinoma.

• DOI: 10.1016/j.celrep.2019.07.059
• 发表时间: 2019-08-20
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Burrack AL;Spartz EJ;Raynor JF;Wang I;Olson M;Stromnes IM
• 通讯作者: Stromnes IM

Polymicrobial Sepsis Chronic Immunoparalysis Is Defined by Diminished Ag-Specific T Cell-Dependent B Cell Responses.

• DOI: 10.3389/fimmu.2018.02532
• 发表时间: 2018
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Sjaastad FV;Condotta SA;Kotov JA;Pape KA;Dail C;Danahy DB;Kucaba TA;Tygrett LT;Murphy KA;Cabrera-Perez J;Waldschmidt TJ;Badovinac VP;Griffith TS
• 通讯作者: Griffith TS

Differential hydrogen sulfide production by a human cohort in response to animal- and plant-based diet interventions.

人类群体响应基于动物和植物的饮食干预而产生的硫化氢差异。

• DOI: 10.1016/j.clnu.2022.03.028
• 发表时间: 2022
• 期刊: Clinical nutrition (Edinburgh, Scotland)
• 作者: Teigen,Levi;Mathai,PrinceP;Lopez,Sharon;Matson,Michael;Elkin,Baila;Kozysa,Daria;Kabage,AmandaJ;Hamilton,Matthew;Vaughn,ByronP;Sadowsky,MichaelJ;Khoruts,Alexander
• 通讯作者: Khoruts,Alexander

Pregnancy-Related Tuberculous Meningitis and Immune Reconstitution Inflammatory Syndrome: A Case Series and Systematic Review.

• DOI: 10.1093/ofid/ofac513
• 发表时间: 2022-10
• 期刊: OPEN FORUM INFECTIOUS DISEASES
• 影响因子: 4.2
• 作者: Pastick, Katelyn A.;Kagimu, Enock;Dobbin, Joanna;Ssebambulidde, Kenneth;Gakuru, Jane;Milln, Jack;Nakabuye, Betty;Meya, David B.;Boulware, David R.;Cresswell, Fiona, V;Bahr, Nathan C.
• 通讯作者: Bahr, Nathan C.