Extracranial Carotid Atherosclerosis Contributions to Cognitive Impairment and Alzheimer's Disease Risk

项目总结 我们的父母奖是一项前瞻性的观察性研究，旨在了解颅外颈动脉的作用。 阿尔茨海默病中的动脉疾病(ECAD)和相关痴呆(ADRD)风险。目标之一是评估 颈动脉内膜剥脱术治疗ECAD对ADRD风险的影响。这项工作涉及到对 与神经退行性变和ADRD相关的基于血液和MRI定义的关键生物标记物。这些生物标志物 在患有ECAD的受试者、没有ECAD的受试者(对照组)和患有ECAD的受试者中进行纵向评估 做了手术的人。颈动脉支架置入术治疗ECAD的安全性得到改善，显著 在这一过程中增加。使用这群接受ECAD并接受颈动脉支架植入术的患者，这 补充奖将评估颈动脉支架植入术(它使斑块保持在适当的位置并已被 与微栓子增加相关)影响与ADRD风险相关的生物学和生物标志物。

PROJECT SUMMARY Our parent award is designed as a prospective, observational study to understand the role of extracranial carotid artery disease (ECAD) in Alzheimer’s disease and related dementias (ADRD) risk. One of the Aims is to evaluate the effects of treatment of ECAD using carotid endarterectomy on ADRD risk. This work involves evaluation of key blood-based and MRI-defined biomarkers associated with neurodegeneration and ADRD. These biomarkers are evaluated longitudinally in subjects with ECAD, subjects without ECAD (controls) and subjects with ECAD who have surgery. Improved safety profiles of carotid artery stenting as treatment for ECAD has led to significant increases in this procedure. Using this cohort of patients who have ECAD and undergo carotid stenting, this Supplemental award will evaluate whether carotid stenting (which leaves the plaque in place and has been associated with increased microemboli) affects biology and biomarkers associated with ADRD risk.