Extracranial Carotid Atherosclerosis Contributions to Cognitive Impairment and Alzheimer's Disease Risk

颅外颈动脉粥样硬化导致认知障碍和阿尔茨海默病风险

• 批准号: 10622999
• 负责人: Craig C Weinkauf
• 金额: $ 38.28万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10622999
• 关键词: Affect; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Award; Biological Markers; Biology; Blood; Carotid Artery Diseases; Carotid Atherosclerotic Disease; Carotid Endarterectomy; Carotid stent; Cephalic; Embolism; Evaluation; Functional disorder; Impaired cognition; Magnetic Resonance Imaging; Nerve Degeneration; Observational Study; Operative Surgical Procedures; Parents; Pathology; Patients; Procedures; Role; Safety; Work; cohort; dementia risk; design; improved; prospective; treatment effect

PROJECT SUMMARY Our parent award is designed as a prospective, observational study to understand the role of extracranial carotid artery disease (ECAD) in Alzheimer’s disease and related dementias (ADRD) risk. One of the Aims is to evaluate the effects of treatment of ECAD using carotid endarterectomy on ADRD risk. This work involves evaluation of key blood-based and MRI-defined biomarkers associated with neurodegeneration and ADRD. These biomarkers are evaluated longitudinally in subjects with ECAD, subjects without ECAD (controls) and subjects with ECAD who have surgery. Improved safety profiles of carotid artery stenting as treatment for ECAD has led to significant increases in this procedure. Using this cohort of patients who have ECAD and undergo carotid stenting, this Supplemental award will evaluate whether carotid stenting (which leaves the plaque in place and has been associated with increased microemboli) affects biology and biomarkers associated with ADRD risk.

项目摘要 我们的家长奖旨在作为一项前瞻性、观察性研究，以了解颅外颈动脉的作用 动脉疾病（ECAD）在阿尔茨海默病和相关痴呆（ADRD）的风险。目的之一是评估 采用颈动脉内膜切除术治疗ECAD对ADRD风险的影响。这项工作包括评估 与神经变性和ADRD相关的关键血液和MRI定义的生物标志物。这些生物标志物 在ECAD受试者、无ECAD受试者（对照）和ECAD受试者中进行纵向评价 做手术的人颈动脉支架植入术作为ECAD治疗的安全性得到改善， 在这一过程中增加。使用ECAD和接受颈动脉支架植入术的患者队列， 补充奖励将评估颈动脉支架植入术（将斑块留在原位， 与微栓子增加相关）影响与ADRD风险相关的生物学和生物标志物。