Administrative Core

行政核心

• 批准号: 10622055
• 负责人: Andrew Serghios Barbas
• 金额: $ 17.58万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10622055
• 关键词: Adherence; Allografting; Clinical; Collaborations; Communication; Complement; Complex; Development; Ensure; Goals; Graft Rejection; Grant; Heart Transplantation; Immune Tolerance; Islets of Langerhans Transplantation; Kidney Transplantation; Logistics; Lung Transplantation; Maintenance; Mission; Modeling; Population; Productivity; Regimen; Regulation; Research; Research Personnel; Resources; Risk; Structure; Transplantation; Transplantation Tolerance; United States National Institutes of Health; allotransplant; biomarker validation; cooperative study; design; improved; member; nonhuman primate; novel; preclinical efficacy; preclinical evaluation; preclinical safety; programs; success

ABSTRACT – Administrative Core The purpose of this Collaborative Program is to bring together investigators focusing on a coordinated and synergistic strategy within the overarching goals of the Nonhuman Primate Transplantation Tolerance Cooperative Study Group (NHPCSG), including: (1) development of novel tolerance induction regimens; (2) evaluation of the preclinical safety and efficacy of existing and newly developed candidate immune tolerance induction regimens; (3) development and validation of biomarkers for the induction, maintenance and/or loss of immune tolerance or for the prediction of graft rejection; and (4) elucidation of the mechanisms underlying the induction, maintenance, and/or loss of tolerance in NHP allograft models of islet, kidney, heart, and/or lung transplantation. In order to coordinate our program’s efforts to achieve these goals, we propose an Administrative Core to manage fiscal and other resources, facilitate interactions and communication, ensure timely progress toward program goals, and ensure adherence to NIH regulations regarding management of the grant.

摘要-行政核心 该合作计划的目的是汇集调查人员集中在一个协调和 非人灵长类动物移植耐受总体目标内的协同战略 合作研究组（NHPCSG），包括：（1）开发新的耐受诱导方案;（2） 评价现有和新开发的候选免疫耐受的临床前安全性和有效性 诱导方案;（3）开发和验证用于诱导、维持和/或丧失 免疫耐受或预测移植物排斥反应;和（4）阐明的机制， 在胰岛、肾、心脏和/或肺的NHP同种异体移植物模型中诱导、维持和/或丧失耐受性 移植为了协调我们的计划的努力，以实现这些目标，我们提出了一个行政 管理财务和其他资源，促进互动和沟通，确保及时进展 实现计划目标，并确保遵守NIH有关管理补助金的规定。