Administrative Core

抽象--管理核心 此协作计划的目的是将调查人员聚集在一起，重点是协调和 非人灵长类移植耐受总体目标中的协同策略 合作研究小组(NHPCSG)，包括：(1)开发新的耐受诱导方案；(2) 现有和新开发的候选免疫耐受的临床前安全性和有效性评价 诱导方案；(3)用于诱导、维持和/或丧失的生物标志物的开发和验证 免疫耐受或移植物排斥反应的预测；以及(4)阐明 NHP同种异体胰岛、肾、心脏和/或肺移植模型的诱导、维持和/或耐受性丧失 移植。为了协调我们计划实现这些目标的努力，我们提出了一个管理 管理财政和其他资源、促进互动和沟通、确保及时进展的核心 实现计划目标，并确保遵守NIH关于拨款管理的规定。

ABSTRACT – Administrative Core The purpose of this Collaborative Program is to bring together investigators focusing on a coordinated and synergistic strategy within the overarching goals of the Nonhuman Primate Transplantation Tolerance Cooperative Study Group (NHPCSG), including: (1) development of novel tolerance induction regimens; (2) evaluation of the preclinical safety and efficacy of existing and newly developed candidate immune tolerance induction regimens; (3) development and validation of biomarkers for the induction, maintenance and/or loss of immune tolerance or for the prediction of graft rejection; and (4) elucidation of the mechanisms underlying the induction, maintenance, and/or loss of tolerance in NHP allograft models of islet, kidney, heart, and/or lung transplantation. In order to coordinate our program’s efforts to achieve these goals, we propose an Administrative Core to manage fiscal and other resources, facilitate interactions and communication, ensure timely progress toward program goals, and ensure adherence to NIH regulations regarding management of the grant.