Modelled estimation of population immunity for coccidioidomycosis and the role of immunologically naïve populations in the shifting epidemiology of coccidioidomycosis in California
球孢子菌病人群免疫力的模型估计以及免疫学上未接触过的人群在加利福尼亚州球孢子菌病流行病学变化中的作用
基本信息
- 批准号:10740731
- 负责人:
- 金额:$ 11.56万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-03 至 2028-07-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAccountingAgeAreaAwarenessBayesian ModelingBiologyBiometryBlack PopulationsBody partCaliforniaCareer MobilityCase StudyCensusesCessation of lifeChronicCoccidioidesCoccidioidomycosisCommunicable DiseasesCommunitiesComputational TechniqueComputing MethodologiesCountyDataDecision MakingDemographyDetectionDevelopmentDiagnosticDiseaseDisparityDroughtsEmerging Communicable DiseasesEnvironmentEnvironmental HealthEpidemiologistEpidemiologyEthnic OriginEthnic PopulationExhibitsFDA approvedFutureGeneral PopulationGeographic LocationsGeographyGoalsGrantHeadHealth systemHispanic PopulationsHumoral ImmunitiesHypersensitivity skin testingImmuneImmunityImmunizeImmunologicsImmunologyIncidenceIndividualInfectionInfectious Disease EpidemiologyInhalationKnowledgeLeadershipLinkLocationMathematicsMeasuresMeningitisMentored Research Scientist Development AwardMentorsMentorshipMethodsMilitary PersonnelModelingMovementMycosesOccupationalPatientsPatternPersonsPhysiciansPopulationPredispositionPrevalenceProbabilityPublic HealthPublishingRaceRecording of previous eventsRecreationReportingReproduction sporesResearchResearch ActivityResearch Project GrantsResource AllocationResourcesRespiratory DiseaseRespiratory Tract InfectionsRiskRisk EstimateRisk FactorsRoleScientistScreening procedureSeriesSeroprevalencesSeveritiesSoilSourceSubgroupSurveysSymptomsSystemTestingTimeTrainingUniversitiesWorkWritingage relatedburden of illnesscareercareer developmentcell mediated immune responseclimate changecommunity acquired pneumoniadata integrationdiagnostic tooldisability-adjusted life yearsdisease transmissionexperiencefaculty mentorhealth care availabilityhealth care disparityhealth care service utilizationinfection risklarge datasetsmortalitymultiple data sourcesneglectracial populationrecruitserosurveyskillssocial epidemiologysocial factorssurveillance datatransmission processvaccination strategy
项目摘要
PROJECT SUMMARY
This K01 award will support the career development of Dr. Jennifer Head, an Epidemiologist in the Division of
Environmental Health Sciences at the University of California, Berkeley. The candidate’s goal is to become a
leader in the development and application of mathematical and statistical approaches to understand the
transmission dynamics of emerging infectious diseases. This application proposes linked career development
and research activities to fill an important gap in understanding population immunity to coccidioidomycosis, an
emerging infectious disease caused by inhalation of soil-dwelling Coccidioides spores. While CDC estimates
nearly 150,000 cases of coccidioidomycosis go uncounted each year, direct methods for estimating population
immunity for coccidioidomycosis are unavailable. Absent estimates of prior immunity for coccidioidomycosis,
we are unable to identify populations experiencing higher rates of under-reporting, understand the role of low
population immunity in the emergence of the disease in new regions, nor explain disparities in infection risk
and case severity. This project aims to advance the candidate’s expertise and skills in computational methods
for robustly estimating prior immunity in populations and incorporating population immunity into models
examining key drivers of disease. The candidate will develop a quantitative Bayesian framework for estimating
prior immunity to coccidioidomycosis by geographic region in California (Aim 1). The candidate will extend the
framework to identify disparities in under-reporting by race and ethnicity, yielding a more accurate assessment
of disparities in disease incidence (Aim 2). Estimates of population immunity will be integrated into a statistical
framework capable of estimating key risk factors for infection in the presence of mobile immune and non-
immune populations (Aim 3). Through partnership with California Department of Public Health, the work will
leverage patient data on >94,000 geolocated cases reported since 2000. The 5-year training plan includes
primary mentorship from three experienced and committed faculty mentors at UC Berkeley with expertise in
biostatistics, infectious disease epidemiology and disease dynamics. Four additional mentors—top leaders in
fungal biology, immunology, demography, and social epidemiology—will support the candidate. Leadership of
the proposed research, along with a training plan involving coursework, and mentored grant writing and project
management, will advance the candidate’s training objectives to: 1) build skills in assessing the role of
population immunity in disease transmission; 2) develop expertise in measuring and integrating social factors
into transmission models; 3) develop skills to overcome computational barriers when working with large
datasets; and 4) strengthen collaborative partnerships and build leadership skills for directing transdisciplinary
research projects. UC Berkeley’s commitment to early career scientists; leadership in epidemiology,
biostatistics, and fungal biology; strong track record of research in infectious diseases; and close partnerships
with public health agencies will provide the candidate an outstanding environment to advance her career goals.
项目总结
这一K01奖项将支持Jennifer Head博士的职业发展,她是#年分部的流行病学家
加州大学伯克利分校环境健康科学专业。候选人的目标是成为一名
在数学和统计方法的开发和应用方面处于领先地位
新发传染病的传播动态。此应用程序建议将职业发展联系起来
和研究活动,以填补在了解人群对球孢子菌病的免疫方面的一个重要空白
因吸入土壤中的球孢子虫孢子而引起的新发传染病。而疾控中心估计
每年有近15万球孢子菌病病例没有统计,这是估计人口的直接方法
不能获得球孢子菌病的免疫力。缺乏对球孢子菌病的先前免疫力的估计,
我们无法确定经历较高漏检率的人群,了解Low的作用
人群免疫力在新地区出现的疾病,也解释不了感染风险的差异
以及案件的严重性。该项目旨在提高候选人在计算方法方面的专业知识和技能
用于稳健地估计人群中的先验免疫并将人群免疫纳入模型
检查疾病的关键驱动因素。候选人将开发一个量化的贝叶斯框架来估计
按加利福尼亚州地理区域划分的球孢子菌病优先免疫力(目标1)。候选人将延长
确定按种族和族裔报告不足的差距的框架,从而产生更准确的评估
消除疾病发病率差异(目标2)。人口免疫力的估计将整合到一个统计数据中
能够在移动免疫和非移动免疫存在的情况下估计感染的关键风险因素的框架
免疫群体(目标3)。通过与加州公共卫生部的合作,这项工作将
利用自2000年以来报告的94,000个地理位置病例的患者数据。五年培训计划包括
加州大学伯克利分校三位经验丰富、尽职尽责的教师导师提供的初级指导
生物统计学、传染病流行病学和疾病动力学。其他四位导师-全球最高领导人
真菌生物学、免疫学、人口学和社会流行病学--将支持候选人。领导力
拟议的研究,以及一项涉及课程作业和指导补助金撰写和项目的培训计划
管理层将把应聘者的培训目标提升到:1)建立评估角色的技能
疾病传播中的人群免疫;2)发展衡量和综合社会因素的专门知识
转化为传输模型;3)开发技能,以克服在处理大型
数据集;以及4)加强协作伙伴关系和培养领导技能,以指导跨学科
研究项目。加州大学伯克利分校致力于早期职业科学家;在流行病学方面的领导地位,
生物统计学和真菌生物学;传染病研究的良好记录;以及密切的伙伴关系
与公共卫生机构的合作将为应聘者提供一个出色的环境来推进她的职业目标。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Jennifer Head其他文献
Jennifer Head的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Jennifer Head', 18)}}的其他基金
Elucidating the role of rodent hosts on the transmission dynamics of coccidioidomycosis in California
阐明啮齿动物宿主对加利福尼亚州球孢子菌病传播动力学的作用
- 批准号:
10216947 - 财政年份:2020
- 资助金额:
$ 11.56万 - 项目类别:
相似海外基金
Unraveling the Dynamics of International Accounting: Exploring the Impact of IFRS Adoption on Firms' Financial Reporting and Business Strategies
揭示国际会计的动态:探索采用 IFRS 对公司财务报告和业务战略的影响
- 批准号:
24K16488 - 财政年份:2024
- 资助金额:
$ 11.56万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Mighty Accounting - Accountancy Automation for 1-person limited companies.
Mighty Accounting - 1 人有限公司的会计自动化。
- 批准号:
10100360 - 财政年份:2024
- 资助金额:
$ 11.56万 - 项目类别:
Collaborative R&D
Accounting for the Fall of Silver? Western exchange banking practice, 1870-1910
白银下跌的原因是什么?
- 批准号:
24K04974 - 财政年份:2024
- 资助金额:
$ 11.56万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A New Direction in Accounting Education for IT Human Resources
IT人力资源会计教育的新方向
- 批准号:
23K01686 - 财政年份:2023
- 资助金额:
$ 11.56万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
An empirical and theoretical study of the double-accounting system in 19th-century American and British public utility companies
19世纪美国和英国公用事业公司双重会计制度的实证和理论研究
- 批准号:
23K01692 - 财政年份:2023
- 资助金额:
$ 11.56万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
An Empirical Analysis of the Value Effect: An Accounting Viewpoint
价值效应的实证分析:会计观点
- 批准号:
23K01695 - 财政年份:2023
- 资助金额:
$ 11.56万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Accounting model for improving performance on the health and productivity management
提高健康和生产力管理绩效的会计模型
- 批准号:
23K01713 - 财政年份:2023
- 资助金额:
$ 11.56万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
CPS: Medium: Making Every Drop Count: Accounting for Spatiotemporal Variability of Water Needs for Proactive Scheduling of Variable Rate Irrigation Systems
CPS:中:让每一滴水都发挥作用:考虑用水需求的时空变化,主动调度可变速率灌溉系统
- 批准号:
2312319 - 财政年份:2023
- 资助金额:
$ 11.56万 - 项目类别:
Standard Grant
New Role of Not-for-Profit Entities and Their Accounting Standards to Be Unified
非营利实体的新角色及其会计准则将统一
- 批准号:
23K01715 - 财政年份:2023
- 资助金额:
$ 11.56万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Improving Age- and Cause-Specific Under-Five Mortality Rates (ACSU5MR) by Systematically Accounting Measurement Errors to Inform Child Survival Decision Making in Low Income Countries
通过系统地核算测量误差来改善特定年龄和特定原因的五岁以下死亡率 (ACSU5MR),为低收入国家的儿童生存决策提供信息
- 批准号:
10585388 - 财政年份:2023
- 资助金额:
$ 11.56万 - 项目类别: