Modelled estimation of population immunity for coccidioidomycosis and the role of immunologically naïve populations in the shifting epidemiology of coccidioidomycosis in California

球孢子菌病人群免疫力的模型估计以及免疫学上未接触过的人群在加利福尼亚州球孢子菌病流行病学变化中的作用

基本信息

  • 批准号:
    10740731
  • 负责人:
  • 金额:
    $ 11.56万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-08-03 至 2028-07-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY This K01 award will support the career development of Dr. Jennifer Head, an Epidemiologist in the Division of Environmental Health Sciences at the University of California, Berkeley. The candidate’s goal is to become a leader in the development and application of mathematical and statistical approaches to understand the transmission dynamics of emerging infectious diseases. This application proposes linked career development and research activities to fill an important gap in understanding population immunity to coccidioidomycosis, an emerging infectious disease caused by inhalation of soil-dwelling Coccidioides spores. While CDC estimates nearly 150,000 cases of coccidioidomycosis go uncounted each year, direct methods for estimating population immunity for coccidioidomycosis are unavailable. Absent estimates of prior immunity for coccidioidomycosis, we are unable to identify populations experiencing higher rates of under-reporting, understand the role of low population immunity in the emergence of the disease in new regions, nor explain disparities in infection risk and case severity. This project aims to advance the candidate’s expertise and skills in computational methods for robustly estimating prior immunity in populations and incorporating population immunity into models examining key drivers of disease. The candidate will develop a quantitative Bayesian framework for estimating prior immunity to coccidioidomycosis by geographic region in California (Aim 1). The candidate will extend the framework to identify disparities in under-reporting by race and ethnicity, yielding a more accurate assessment of disparities in disease incidence (Aim 2). Estimates of population immunity will be integrated into a statistical framework capable of estimating key risk factors for infection in the presence of mobile immune and non- immune populations (Aim 3). Through partnership with California Department of Public Health, the work will leverage patient data on >94,000 geolocated cases reported since 2000. The 5-year training plan includes primary mentorship from three experienced and committed faculty mentors at UC Berkeley with expertise in biostatistics, infectious disease epidemiology and disease dynamics. Four additional mentors—top leaders in fungal biology, immunology, demography, and social epidemiology—will support the candidate. Leadership of the proposed research, along with a training plan involving coursework, and mentored grant writing and project management, will advance the candidate’s training objectives to: 1) build skills in assessing the role of population immunity in disease transmission; 2) develop expertise in measuring and integrating social factors into transmission models; 3) develop skills to overcome computational barriers when working with large datasets; and 4) strengthen collaborative partnerships and build leadership skills for directing transdisciplinary research projects. UC Berkeley’s commitment to early career scientists; leadership in epidemiology, biostatistics, and fungal biology; strong track record of research in infectious diseases; and close partnerships with public health agencies will provide the candidate an outstanding environment to advance her career goals.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Jennifer Head其他文献

Jennifer Head的其他文献

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{{ truncateString('Jennifer Head', 18)}}的其他基金

Elucidating the role of rodent hosts on the transmission dynamics of coccidioidomycosis in California
阐明啮齿动物宿主对加利福尼亚州球孢子菌病传播动力学的作用
  • 批准号:
    10216947
  • 财政年份:
    2020
  • 资助金额:
    $ 11.56万
  • 项目类别:

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