Elucidating the role of gut microbiota in colitis-associated colorectal cancer

阐明肠道微生物群在结肠炎相关结直肠癌中的作用

基本信息

  • 批准号:
    10564074
  • 负责人:
  • 金额:
    $ 64.91万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-01-01 至 2027-12-31
  • 项目状态:
    未结题

项目摘要

Abstract Patients with ulcerative colitis (UC), an inflammatory bowel disease (IBD), have an increased risk of developing colitis-associated colorectal cancer (CAC). Human gut microbiome composition has recently been associated with a wide array of diseases, including IBD and colorectal cancer. Studies have shown that gut microbiota could influence colon epithelium to initiate or promote colorectal cancer development directly or indirectly. However, little is known on the structure and function of the microbiota in CAC and how they implicate the development of CAC at the molecular level. In this study, we will investigate the role of microbiota in the development of CAC, as well as the molecular events underlying the interplay of microbiota and host response. The project builds upon our previous studies in examining the genomic instabilities and proteome alterations in the colon epithelium during the pathogenesis of IBD-CAC, and will focus on the mechanistic and functional involvement of the microbiome and their components in the modulation (by protective bacteria) or activation (by tumorigenic bacteria) of CAC development. Specifically, we will investigate the implication of mucosa- associated microbiota in CAC by an integrated approach using three model systems, including clinical specimens (Aim 1), in vitro microbial cultivation and organoid models (Aim 2), and in vivo mouse model (Aim 3). Our integrative, state-of-the-art approach will characterize the composition, functional genes and pathways of the microbiome implicated in CAC, and the impact of microbiota on colon mucosa. By studying the gut microbiota and its interplay with the colon host using novel approaches and cutting-edge technology, our study has significant translational potential that could lead to establishing the gut microbiome as predictors of CAC risk and aid in developing approaches for CAC prevention and detection in IBD patients.
摘要

项目成果

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Ru Chen其他文献

Ru Chen的其他文献

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{{ truncateString('Ru Chen', 18)}}的其他基金

Biomarkers for Early Detection of Colorectal Cancer in Ulcerative Colitis
溃疡性结肠炎中结直肠癌早期检测的生物标志物
  • 批准号:
    10172861
  • 财政年份:
    2017
  • 资助金额:
    $ 64.91万
  • 项目类别:
Biomarkers for Early Detection of Colorectal Cancer in Ulcerative Colitis
溃疡性结肠炎中结直肠癌早期检测的生物标志物
  • 批准号:
    10406961
  • 财政年份:
    2017
  • 资助金额:
    $ 64.91万
  • 项目类别:
Biomarkers for Early Detection of Colorectal Cancer in Ulcerative Colitis
溃疡性结肠炎中结直肠癌早期检测的生物标志物
  • 批准号:
    9700068
  • 财政年份:
    2017
  • 资助金额:
    $ 64.91万
  • 项目类别:
Biomarkers for Early Detection of Colorectal Cancer in Ulcerative Colitis
溃疡性结肠炎中结直肠癌早期检测的生物标志物
  • 批准号:
    9382167
  • 财政年份:
    2017
  • 资助金额:
    $ 64.91万
  • 项目类别:
Early detection of pancreatic cancer in diabetics
糖尿病患者胰腺癌的早期发现
  • 批准号:
    9252236
  • 财政年份:
    2014
  • 资助金额:
    $ 64.91万
  • 项目类别:
Early detection of pancreatic cancer in diabetics
糖尿病患者胰腺癌的早期发现
  • 批准号:
    8695193
  • 财政年份:
    2014
  • 资助金额:
    $ 64.91万
  • 项目类别:
Mitochondria proteome of ulcerative colitis associated dysplasia
溃疡性结肠炎相关发育不良的线粒体蛋白质组
  • 批准号:
    8510603
  • 财政年份:
    2012
  • 资助金额:
    $ 64.91万
  • 项目类别:
Mitochondria proteome of ulcerative colitis associated dysplasia
溃疡性结肠炎相关发育不良的线粒体蛋白质组
  • 批准号:
    8374386
  • 财政年份:
    2012
  • 资助金额:
    $ 64.91万
  • 项目类别:
Pancreatic Juice Biomarker for Pancreatic Cancer
胰腺癌的胰液生物标志物
  • 批准号:
    8309082
  • 财政年份:
    2011
  • 资助金额:
    $ 64.91万
  • 项目类别:
Pancreatic Juice Biomarker for Pancreatic Cancer
胰腺癌的胰液生物标志物
  • 批准号:
    8166376
  • 财政年份:
    2011
  • 资助金额:
    $ 64.91万
  • 项目类别:

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