NEIBank: Est Analysis And Bioinformatics For Ocular Genomics

NEIBank：眼部基因组学的 Est 分析和生物信息学

• 批准号: 10930501
• 负责人: graeme j wistow
• 金额: $ 7.7万
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10930501
• 关键词: Bioinformatics; Collaborations; Data; Dedications; Disease; Eye; Eye diseases; Future; Gene Combinations; Genes; Genome; Genomics; Human; Modeling; Pattern; Proteins; RNA analysis; Research; Research Personnel; Resources; Serum; Source; Starvation; Structure; Structure of retinal pigment epithelium; Vision; data visualization; genome browser; informatics tool; tool; transcriptome sequencing

NEIBank and EyeBrowse (a dedicated genome browser for eye-expressed genes, produced in collaboration with CIT. http://eyebrowse.cit.nih.gov/genome/)consitiute a resource for eye research worldwide. We have developed new informatics tools for functional analysis of RNA-seq data. We combine gene annotations from multiple sources with highly interactive data visualization. This greatly enhances the ease with which important patterns in the data can be discerned. We have applied this approach to expression data for our AMD-related models of retinal pigment epithelium serum starvation. Current efforts are aimed at maintaining the functionality of NEIBank, particularly EyeBrowse for the future.

NEIBank和EyeBrowse（与CIT合作开发的眼睛表达基因的专用基因组浏览器）。http：//eyebrowse.cit.nih.gov/genome/）构成了全世界眼睛研究的资源。 我们开发了新的信息学工具，用于RNA-seq数据的功能分析。我们将来自多个来源的联合收割机基因注释与高度交互的数据可视化相结合。这大大提高了识别数据中重要模式的容易性。我们已经将这种方法应用于我们的AMD相关模型的视网膜色素上皮血清饥饿的表达数据。 目前的努力旨在维护NEIBank的功能，特别是未来的EyeBrowse。