课题基金 / 基金详情

SERVICES FOR THE CHARACTERIZATION OF ABSORPTION, DISTRIBUTION, METABOLISM, EXCRETION, AND TOXICITY (ADMET) PROPERTIES OF SMALL-MOLECULE DRUG CANDIDATES USING STANDARDIZED IN VITRO METHODS IN SUPPORT O

使用标准化体外方法表征小分子候选药物的吸收、分布、代谢、排泄和毒性 (ADMET) 特性的服务

批准号：

10936131

负责人：

RALF GEIBEN LYNN

金额：

$5.63万

依托单位：

依托单位国家：

美国

项目类别：

财政年份：

2023

资助国家：

美国

项目状态：

已结题

起止时间：

2023-09-18 至 2024-09-17

来源：

https://reporter.nih.gov/project-details/10936131

关键词：

Adverse effects Animals Behavior Biological Biological Assay Cells Chemicals Contracts Data Development Drug Kinetics Enzymes Excretory function Human In Vitro Metabolism Methods Molecular Permeability Pharmaceutical Preparations Phase Process Property Services Solubility Standardization Testing Time Tissues Toxic effect absorption analog behavior prediction clinical candidate design drug candidate drug development drug discovery experimental study in vitro Assay in vivo lead candidate novel programs small molecule

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中文摘要

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英文摘要

The purpose of this contract is to determine in vitro ADMET (absorption, distribution, metabolism, excretion, toxicity) in two novel compounds using molecular methods. These experiments will help determine the drug-like properties of these novel compounds and their suitability for further development.

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