MOLECULAR EPIDEMIOLOGY OF PROSTATE CANCER

该提案的目的是调查各种潜在的 可能增加或减少前列腺疾病风险的因素 癌症是一种病因学知之甚少的疾病。协会 前列腺癌与潜在致癌物接触（有机氯 化合物，镉和锌），易感因素（GSTM 1基因型）和 其他风险和/或保护因素（内源性激素，微量营养素， 脂肪酸）将使用巢式病例对照进行前瞻性检查 研究设计. 这项研究将使用1974年收集的诊断前血清进行 1989年在华盛顿县马里兰州发现的血浆。血清和血浆将 检测有机氯化合物、锌、镉、硒、视黄醇， 类胡萝卜素，生育酚，抗坏血酸，总抗氧化活性，脂肪 酸、内源性激素和GSTMI基因分型将使用血沉棕黄 收藏于1989年据估计，424名患有前列腺疾病的男性 献血后的癌症将与年龄匹配的对照组进行比较 和性别，并且在诊断病例时没有其他癌症。 这些因素对前列腺疾病风险的独立和修饰作用 癌症将被检查。 从病因学的角度来看，研究结果将有助于理解 环境有机氯化合物暴露的贡献，镉 和锌暴露对前列腺癌的发展和潜在的 对这些化合物的遗传易感性。从 预防的观点，抗氧化剂和脂肪酸的改善作用， 有机氯化合物和前列腺之间的关联 癌症值得特别关注，因为这些因素是 采取切实可行的预防措施。

The objective of this proposal is to investigate a variety of potential factors that may increase or decrease the risk of developing prostate cancer, a disease whose etiology is poorly understood. Associations of prostate cancer with potential carcinogenic exposures (organochlorine compounds, cadmium and zinc), a susceptibility factor (GSTM1 genotype) and other risk and/or protective factors (endogenous hormones, micronutrients, fatty acids) will be examined prospectively using a nested case-control study design. The study will be conducted using prediagnostic serum collected in 1974 and plasma from 1989 in Washington County Maryland. Serum and plasma will be assayed for organochlorine compounds, zinc, cadmium, selenium, retinol, carotenoids, tocopherols, ascorbic acid, total antioxidant activity, fatty acids, endogenous hormones and GSTMI genotyping will be done using buffy coats collected in 1989. An estimated 424 men who have developed prostate cancer after donating blood will be compared with controls matched on age and gender and free of other cancers at the time of diagnosis of the case. Independent and modifying effects of these factors on the risk of prostate cancer will be examined. From the viewpoint of etiology, findings will aid in understanding the contribution of environmental organochlorine compound exposure, cadmium and zinc exposure to the development of prostate cancer and the potential inherited susceptibility to the effects of these compounds. From the viewpoint of prevention, the modifying effects of antioxidants and fatty acids on the association between organochlorine compounds and prostate cancer deserve particular attention since these are factors that are amenable to practical preventive measures.