IDIOPATHIC INTRAUTERINE GROWTH RETARDATION EPIDEMIOLOGY

特发性宫内生长迟缓流行病学

• 批准号: 2025831
• 负责人: JUN ZHANG
• 金额: $ 7.96万
• 依托单位: MOUNT SINAI SCHOOL OF MEDICINE OF CUNY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-12-09 至 1997-07-06
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2025831
• 关键词: alpha fetoprotein; cephalometry; chlamydial disease; disease /disorder proneness /risk; epidemiology; gestational age; human birth weight; human data; human morbidity; infant mortality; pregnancy disorder; prenatal growth disorder; racial /ethnic difference

DESCRIPTION: (Adapted from Investigator's Abstract) Intrauterine growth retardation (IUGR) is a major cause of perinatal mortality and morbidity which may be amenable to prevention and intervention. However, approximately 40% of IUGR has no obvious cause. To create a strategic basis for prevention, more efforts are warranted to identify risk factors for idiopathic IUGR. This study aims to identify risk factors/predictors for idiopathic IUGR and subtypes (symmetric and asymmetric) with special focus on chlamydia infection and maternal serum alpha-fetoprotein. In addition, this study will go beyond the conventional definitions of birth-weight-for-gestational-age referenced IUGR (the 10th percentile) and symmetry of fetal growth (Ponderal index), and it will explore better race-specific definitions of symmetric and asymmetric IUGR, incorporating clinical and anthropometric measurements. Racial differences in incidence rates, patterns of IUGR, and neonatal mortality and morbidity will be compared and race-specific risk factors investigated. Data for this project are derived from the obstetric and neonatal databases in the Department of Obstetrics, Gynecology and Reproductive Sciences, and the Department of Pediatrics in the Mount Sinai Medical Center in New York, with approximately 40,000 ethnically and socioeconomically diverse pregnancies and over 1000 variables for each mother-neonate pair. The specific aims of the study are as follow. (1) Define IUGR and symmetry of fetal growth incorporating birth weight, crown-heel length, head circumference, gestational age, and perinatal mortality. (2) Compare the distribution and incidence rates of symmetric and asymmetric IUGR in Asians, blacks, Hispanics and whites. (3) Examine the neonatal morbidity and mortality in relation to symmetric and asymmetric IUGR, and the racial differences. (4) Identify risk factors/predictors for idiopathic symmetry and asymmetry IUGR in different ethnic groups. (5) Examine the associations between chlamydia infection during pregnancy and idiopathic IUGR, and between maternal serum alpha-fetoprotein and idiopathic IUGR. (6) Finally, compare the results based on the new definitions of IUGR and symmetry with those based on 10th percentile and ponderal index.

描述：（改编自研究者摘要）子宫内生长 发育迟缓（IUGR）是围产期死亡率和发病率的主要原因 这可能是可以预防和干预的。 然而， 大约 40% 的 IUGR 没有明显原因。 创造战略基础 为了预防，需要付出更多努力来识别风险因素 特发性IUGR。 本研究旨在确定风险因素/预测因素 特别关注特发性 IUGR 和亚型（对称和不对称） 衣原体感染和母体血清甲胎蛋白。 此外， 这项研究将超越传统的定义 胎龄出生体重参考IUGR（第10个百分位）和 胎儿生长的对称性（Ponderal指数），将更好地探索 对称和不对称 IUGR 的种族特定定义，包括 临床和人体测量。 发病率的种族差异 IUGR 的比率、模式以及新生儿死亡率和发病率将 比较和调查种族特定的危险因素。 该项目的数据 来自产科和新生儿科的数据库 妇产科和生殖科学系 纽约西奈山医疗中心的儿科，大约有 40,000 次不同种族和社会经济背景的怀孕，以及超过 1000 次 每对母亲-新生儿的变量。 研究的具体目的如下。 (1) IUGR和对称性的定义 胎儿生长情况，包括出生体重、头跟长度、头部 周长、胎龄和围产儿死亡率。 (2)比较 亚洲人对称和不对称 IUGR 的分布和发病率， 黑人、西班牙裔和白人。 (3) 检查新生儿发病率 与对称和不对称 IUGR 相关的死亡率以及种族 差异。 (4) 识别特发性对称性的风险因素/预测因素 不同种族中IUGR的不对称性。 (5)检查协会 妊娠期间衣原体感染与特发性 IUGR 之间的关系，以及 母体血清甲胎蛋白与特发性 IUGR 之间的关系。 （6）最后， 将基于 IUGR 和对称性的新定义的结果与 那些基于第 10 个百分位数和重量指数。