ROC EVALUATION OF TC-99M CARDIAC SPECT METHODS

TC-99M 心脏光谱方法的 ROC 评估

• 批准号: 2430740
• 负责人: DAVID R GILLAND
• 金额: $ 12.36万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-06-01 至 1999-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2430740
• 关键词: cardiovascular imaging /visualization; evaluation /testing; single photon emission computed tomography; technetium

DESCRIPTION (Adapted from Applicant's Abstract): The applicants have proposed to improve the image quality and diagnostic effectiveness of Tc-99m myocardial perfusion imaging with single photon emission computed tomography (SPECT). The importance of this clinical procedure in the diagnosis of heart disease is clearly established, and there is a need for the development and careful evaluation of improved imaging methods. This application will address several issues in Tc-99m myocardial SPECT, presenting new methods for improving the quality of the SPECT image and evaluating the methods using receiver operating characteristic (ROC) analysis. The ROC studies will use data acquired from anthropomorphic thorax phantoms that model the attenuation and source distributions of patients during Tc-99m myocardial perfusion imaging. The ability of human observers to detect simulated perfusion defects will be measured in the reconstructed phantom image obtained using the proposed SPECT methods. The specific issues that will be considered include: 1.) 360 versus 180 degree data acquisition and reconstruction. Image quality can be greatly affected by this choice, and for defect detection in Tc-99m myocardial perfusion SPECT with multihead cameras, it is not clear which technique is superior. These alternative approaches will be investigated, considering the effect of defect location and body size; 2.) Non-uniform attenuation compensation using acquire transmission data. Acquisition and processing methods for transmission computed tomography (TCT) with a three-headed SPECT system will be presented and evaluated. The TCT system design used a Tc-99m line source with fan beam collimator. The acquisition is complicated by the presence of the Tc-99m perfusion tracer within the body, and methods are proposed for reducing the influence of the tracer in the TCT data. Non-uniform attenuation compensation of the SPECT image using the reconstructed TCT data will be compared with uniform and no compensation; and 3.) Three- dimensional iterative reconstruction. Iterative reconstruction methods will be developed and evaluated that model in three dimensions the important physical processes in SPECT imaging. The effects of attenuation, scatter and detector response will be incorporated into iterative algorithms, such as maximum likelihood-expectation maximization (ML-EM), and compared with the filtered backprojection (FB) methods considered earlier in the proposed study.

描述（改编自申请人摘要）：申请人有 建议提高图像质量和诊断效果， 单光子发射计算的Tc-99 m心肌灌注成像 断层扫描（SPECT）。 这一临床程序的重要性 心脏病的诊断是明确的，有必要 用于开发和仔细评估改进的成像方法。 该应用将解决Tc-99 m心肌SPECT中的几个问题， 提出了改善SPECT图像质量的新方法， 使用受试者工作特征（ROC）评价方法 分析. ROC研究将使用从拟人模型中获得的数据， 胸部模型，模拟衰减和源分布， Tc-99 m心肌灌注显像。 的能力 将测量人类观察者以检测模拟灌注缺陷 在使用所提出的SPECT获得的重建体模图像中， 方法. 将考虑的具体问题包括：（1）360 对比180度数据采集和重建。 图像质量 可能会受到这种选择的很大影响， Tc-99 m心肌灌注SPECT与多头摄像机，它不是 明确哪种技术更上级。 这些替代方法将 考虑到缺陷位置和基体的影响， 2.使用获取传输的非均匀衰减补偿 数据 传输计算的采集和处理方法 断层扫描（TCT）与三头SPECT系统将提出， 评估。 TCT系统设计采用带风扇的Tc-99 m线源 射束准直器 收购是复杂的存在 Tc-99 m灌注示踪剂在体内的作用，并提出了用于 减少TCT数据中示踪剂的影响。非均匀 使用重建的TCT对SPECT图像进行衰减补偿 数据将与统一和无补偿进行比较;以及3.）三个-- 三维迭代重建 迭代重建方法 将在三个维度上开发和评估该模型， SPECT成像中的重要物理过程。 的影响 衰减，散射和探测器响应将被纳入 迭代算法，如最大似然期望 最大化（ML-EM），并与滤波反投影（FB） 这是在先前研究中提出的方法。