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Disease model design and evaluation

Disease model design and evaluation
疾病模型设计与评估
批准号：
10910768
负责人：
Craig Thomas
金额：
$46.59万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10910768
关键词：
3-DimensionalArchitectureBiopsyCell modelCellsComplexDataDiseaseDisease modelEvaluationGenomicsHeterogeneityHumanManuscriptsMethodologyMethodsModelingMolecularMolecular and Cellular BiologyOrganoidsOutcomePatientsPeer ReviewPharmaceutical PreparationsPhysiologicalPositioning AttributeProteomicsPublishingTechniquesTechnologyTissue ModelTissue SampleTissuescomparativedrug discoveryexperimental studyfacsimileinnovationinsightmetabolomicsmodel designnext generationnovelnovel drug classnovel therapeuticsscreeningsmall moleculethree dimensional cell culturetissue culturetissue/cell culturetranscriptomics

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中文摘要
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英文摘要
Our team has utilized next-generation techniques in cell culture and tissue culture modeling to explore concepts in disease origin, progression, and treatment without invasive and unfounded experiments on patients. We characterize these models using a variety of omics technologies and single cell methods. We have published our results in peer-reviewed manuscripts and utilized the data generated to further expand our chemogenomics methods for defining new therapy concepts to treat complex diseases.
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Development of a novel aIIbB3 receptor antagonist for pre-hospital myocardial infarction therapy
Development of a first-in-class O-GlcNAc transferase (OGT) inhibitor
Novel small molecule library development
The development of multikinase inhibitors for the treatment of selected cancers
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