T32 University of Rochester Aging and Alzheimer's disease Training Program

T32 罗切斯特大学老龄化和阿尔茨海默病培训项目

• 批准号: 10617780
• 负责人: M. KERRY O'BANION
• 金额: $ 32.93万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10617780
• 关键词: Aging; Alzheimer' s Disease; Training Programs; Universities

While fewer older adults are dying from heart disease and cancer, deaths from Alzheimer’s disease and related dementia’s (ADRD) have risen 145% in the last two decades. Progress to find a solution to this public health crisis has been slow. To help accelerate progress in the understanding, treatment, and prevention of ADRD, this application is for establishment of an NIA Institutional National Research Service Award (T32) titled, “University of Rochester Aging and Alzheimer’s Disease Training Program (UR-AADTP)”. Consistent with longstanding and established strengths at the University of Rochester in foundational and translational research on aging and ADRD, our goal is to accelerate the development and application of strategies to reduce the morbidity and mortality associated with ADRD. We seek support for six predoctoral fellows (3 slots in year 1) in basic and translational research programs who will undergo an innovative curriculum that emphasizes interdisciplinary science and informs their training through interactions with people affected by dementia and their health care providers. The UR-AADTP’s primary objective is to develop a cadre of early-stage scientists with the depth and breadth of knowledge, skills, appreciation, and experience necessary to establish careers as independent investigators in the area of dementia research; to work in an interdisciplinary environment designed to aggressively translate research to practice; and to reduce the toll of cognitive disorders in later life. The UR- AADTP T32 has these specific aims: Aim 1: We will recruit a diverse group of highly qualified predoctoral trainees who are committed to careers in aging research, retain them until their training is complete, and support their successful transitions to post- graduate academic positions. The trainees’ diversity will be reflected in their racial/ethnic backgrounds as well as the range of scientific disciplines and areas of research interest that they represent. Aim 2: Through courses, seminars and workshops, and mentored research experiences, we will provide UR- AADTP T32 trainees with a firm foundation in the theories and methods of basic and early translational aging research that are necessary for study of dementia pathogenesis and treatment development. Aim 3: By fostering interactions between trainees and faculty members trained in different theoretical and methodological approaches to aging and dementia research, we will stimulate interdisciplinary collaborations in aging research that accelerate the progress of dementia research, treatment and prevention. Aim 4: Through structured exposure to clinical settings, people affected by dementia, and the providers that care for them, trainees will appreciate the connections between research and practice necessary to accelerate the development of effective approaches to illness prevention and mitigation. Aim 5: We will rigorously evaluate the program and its participants (faculty and trainees).

虽然死于心脏病和癌症的老年人越来越少，但死于阿尔茨海默病和相关疾病的人 痴呆症(ADRD)的发病率在过去20年里上升了145%。为解决这一公共卫生问题而取得的进展 危机一直很缓慢。为了帮助加快在了解、治疗和预防ADRD方面的进展，这 申请设立NIA机构国家研究服务奖(T32)，名称为 罗切斯特老龄化和阿尔茨海默病培训方案(UR-AADTP)。与长期以来的和 罗切斯特大学在老龄化和翻译性研究方面的成熟优势 ADRD，我们的目标是加快制定和应用战略，以减少发病率和 与ADRD相关的死亡率。我们寻求对6名博士前研究员(1年级3个名额)基础和 将接受强调跨学科的创新课程的翻译研究计划 科学，并通过与痴呆症患者的互动和他们的医疗保健来告知他们的培训 供应商。UR-AADTP的主要目标是培养一支具有深度和 广博的知识、技能、鉴赏力和经验，是建立独立职业所必需的 痴呆症研究领域的研究人员；在跨学科环境中工作 积极地将研究转化为实践；并在晚年减少认知障碍的代价。UR- AADTP T32有以下具体目标： 目标1：我们将招聘一批高素质的博士前实习生，他们致力于 老龄化研究，留住他们，直到他们的培训完成，并支持他们成功过渡到后 研究生学术职位。学员的多样性也将反映在他们的种族/民族背景上。 作为它们所代表的科学学科和研究兴趣领域的范围。 目标2：通过课程、研讨会和工作坊，以及指导研究经验，我们将提供UR- AADTP T32学员，在基础和早期翻译老化的理论和方法方面有扎实的基础 对痴呆症发病机制和治疗发展的研究是必要的。 目标3：通过促进学员和教职员工之间的互动，在不同的理论和 衰老和痴呆症研究的方法论方法，我们将鼓励跨学科合作 加速痴呆症研究、治疗和预防的老龄化研究。 目标4：通过有组织地接触临床环境、受痴呆症影响的人以及 关心他们，受训者将理解研究和实践之间的联系，这是加速 制定预防和减轻疾病的有效方法。 目标5：我们将严格评估该计划及其参与者(教职员工和实习生)。