CORE 4- Small Animal Core
CORE 4-小动物核心
基本信息
- 批准号:10625691
- 负责人:
- 金额:$ 18.26万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-03-03 至 2028-02-29
- 项目状态:未结题
- 来源:
- 关键词:AnimalsAntibodiesAntigensBoard CertificationClostridium difficileDevelopmentGoalsInfectionLaboratoriesLeadModelingMusPathologistPathologyProgram DevelopmentProteinsResource SharingTestingTrainingTreatment EfficacyVaccinesVeterinary Anatomydigital pathologyefficacy testingexperiencehuman diseasehuman modelin vivo Modelmolecular pathologymouse modelnovel vaccinespreventprogramssmall moleculetherapeutic evaluationvaccine development
项目摘要
SUMMARY-SMALL ANIMAL CORE
A critical component of our vaccine development program is efficacy testing of candidate antigens in murine
models of C. difficile infection. The Small Animal Core of our program will achieve this goal and identify lead
antigens for the development of novel vaccines to prevent against CDI. The Small Animal Core will be led by Dr.
Eric Skaar. The Skaar laboratory has significant experience in the murine model of C. difficile infection and has
also developed a new live C. difficile vaccine model in mice as described in Project 2. In addition, the Skaar
laboratory has experience testing the therapeutic efficacy of both small molecules and antibodies in murine
models. This experience will be used to guide the creation of a Small Animal Core to test the efficacy of lead
antigens developed by this program. The Small Animal Core will benefit from the expertise of the Translational
Pathology Shared Resource (TPSR) which includes access to a board-certified veterinary pathologist with
experience in in vivo modeling of human disease, including molecular pathology, toxicopathologic assessment,
and digital pathology as well as advanced training in veterinary anatomic pathology and murine models. The
Small Animal Core will receive optimized candidate antigens from Scientific Core 2. These proteins will be tested
for efficacy in appropriate murine models of CDI. Candidate antigens will be tested alone or in combination.
Combined, the efforts of the Small Animal Core will result in the identification of lead antigens for the development
of novel vaccines that protect against infections caused by C. difficile.
总结-小动物核心
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Eric P Skaar其他文献
Eric P Skaar的其他文献
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{{ truncateString('Eric P Skaar', 18)}}的其他基金
Project 2: Discovery of novel C. difficile antigens using genetic and biochemical approaches
项目2:利用遗传和生化方法发现新的艰难梭菌抗原
- 批准号:
10625693 - 财政年份:2023
- 资助金额:
$ 18.26万 - 项目类别:
Calprotectin modulates neutrophil function during Staphylococcus aureus infection of the heart
钙卫蛋白在心脏金黄色葡萄球菌感染期间调节中性粒细胞功能
- 批准号:
10464764 - 财政年份:2022
- 资助金额:
$ 18.26万 - 项目类别:
Nutritional immunity and microbial competition during Clostridioides difficile infection
艰难梭菌感染期间的营养免疫和微生物竞争
- 批准号:
10643887 - 财政年份:2022
- 资助金额:
$ 18.26万 - 项目类别:
Nutritional immunity and microbial competition during Clostridioides difficile infection
艰难梭菌感染期间的营养免疫和微生物竞争
- 批准号:
10538799 - 财政年份:2022
- 资助金额:
$ 18.26万 - 项目类别:
Calprotectin modulates neutrophil function during Staphylococcus aureus infection of the heart
钙卫蛋白在心脏金黄色葡萄球菌感染期间调节中性粒细胞功能
- 批准号:
10573312 - 财政年份:2022
- 资助金额:
$ 18.26万 - 项目类别:
Developing the VUMC MICRO facility to advance innovative BSL3 research
开发 VUMC MICRO 设施以推进创新 BSL3 研究
- 批准号:
10596928 - 财政年份:2022
- 资助金额:
$ 18.26万 - 项目类别:
The Staphylococcus aureus response to nutrient zinc restriction during infection
金黄色葡萄球菌感染期间对营养锌限制的反应
- 批准号:
10548202 - 财政年份:2020
- 资助金额:
$ 18.26万 - 项目类别:
The Staphylococcus aureus response to nutrient zinc restriction during infection
金黄色葡萄球菌感染期间对营养锌限制的反应
- 批准号:
10335212 - 财政年份:2020
- 资助金额:
$ 18.26万 - 项目类别:
Molecular mapping of microbial communities at the host-pathogen interface by multi-modal 3-dimensional imaging mass spectrometry
通过多模态 3 维成像质谱法绘制宿主-病原体界面微生物群落的分子图谱
- 批准号:
10231176 - 财政年份:2018
- 资助金额:
$ 18.26万 - 项目类别:
Molecular mapping of microbial communities at the host-pathogen interface by multi-modal 3-dimensional imaging mass spectrometry
通过多模态 3 维成像质谱法绘制宿主-病原体界面微生物群落的分子图谱
- 批准号:
10465090 - 财政年份:2018
- 资助金额:
$ 18.26万 - 项目类别:
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