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Low Neurophysiologic Resistance to Anesthetics as a Marker of Preclinical/Prodromal Alzheimer's Disease and Neurovascular Pathology, Delirium risk and Inattention

Low Neurophysiologic Resistance to Anesthetics as a Marker of Preclinical/Prodromal Alzheimer's Disease and Neurovascular Pathology, Delirium risk and Inattention
对麻醉药的神经生理学抵抗力低是临床前/前驱阿尔茨海默病和神经血管病理学、谵妄风险和注意力不集中的标志
批准号:
10870632
负责人:
Miles Berger
金额:
$33.63万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
未结题
起止时间:
2022-08-01 至 2027-04-30

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英文摘要
SUMMARY In the parent R01 research project entitled "Low Neurophysiologic Resistance to Anesthetics as a Marker of Preclinical/Prodromal Alzheimer's Disease and Neurovascular Pathology, Delirium risk and Inattention," we are examining whether - neurodegenerative disease-type changes in brain structure and activity, predispose patients to show altered brain activity changes in response to anesthetic drugs provided during surgery. This R01 project exploits the idea that altered brain activity in response to anesthetic drugs reflects an unhealthy brain, which may have latent signs of pre-clinical AD and which may indicate an increased risk of POD. The expected outcome of the R01 project is to understand better the mechanisms underlying intraoperative brain EEG responses to anesthetic drugs, postoperative delirium, Alzheimer s Disease and related dementias, and relationships between these entities. In this Administrative Supplement application, we propose to investigate the relationship between preclinical/ prodromal Lewy body dementia (LBD) pathology (ie altered forms of a protein called alpha synuclein) . It has been well established that patients with delirium and dementia display similar EEG abnormalities in pre-alpha/theta frequencies and dominant frequency overall, similar to patients with LBD. Thus, EEG activity patterns during anesthesia may be able to serve as an indicator -Synuclein levels, which might help to identify at risk patients for further workup for LBD, AD, and other related dementias.2-4
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APOE4 dependent regulation of CSF Complement Pathway Activation in the development of Alzheimer's Disease
  • 批准号:
    10650372
  • 项目类别:
  • 资助金额:
    $78.47万
  • 财政年份:
    2022
  • 负责人:
    Miles Berger
  • 依托单位:
Low Neurophysiologic Resistance to Anesthetics as a Marker of Preclinical/Prodromal Alzheimer's Disease and Neurovascular Pathology, Delirium risk and Inattention
  • 批准号:
    10671023
  • 项目类别:
  • 资助金额:
    $74.98万
  • 财政年份:
    2022
  • 负责人:
    Miles Berger
  • 依托单位:
Low Neurophysiologic Resistance to Anesthetics as a Marker of Preclinical/Prodromal Alzheimer's Disease and Neurovascular Pathology, Delirium risk and Inattention
  • 批准号:
    10521860
  • 项目类别:
  • 资助金额:
    $78.42万
  • 财政年份:
    2022
  • 负责人:
    Miles Berger
  • 依托单位:
APOE4 dependent regulation of CSF Complement Pathway Activation in the development of Alzheimer's Disease
  • 批准号:
    10871775
  • 项目类别:
  • 资助金额:
    $40.22万
  • 财政年份:
    2022
  • 负责人:
    Miles Berger
  • 依托单位:
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