AEROBIC EXERCISE INTERVENTION IN A MULTIETHNIC SYMPTOMATIC HIV-1 INFECTED SAMPLE

拟议的项目扩展了我们由NIMH资助的行为研究 针对人类免疫缺陷病毒1型感染者的干预措施 (HIV-1)感染。这些研究表明，一个适度的计划 无症状健康男同性恋者的有氧运动训练 接受HIV-1阳性诊断，降低自我报告水平 焦虑、抑郁和无助，同时保持积极应对 血清阳性消息后的策略和社会支持。这个 目前为期5年的前瞻性研究将确定是否类似于 心理健康可以通过有氧运动训练，由非洲人- 和非西班牙裔白人美国男性和女性，患有早期症状的艾滋病毒- 1感染(世界卫生组织阶段-3；世卫组织，1990年)，无论 曝光类别。到目前为止，还没有实验设计的 有症状前期的前瞻性压力管理干预研究 艾滋病多民族男性和女性被吸引到各个暴露类别。这 干预：根据我们在#年进行有氧运动训练的经验 在过去的五年中，HIV-1血清阳性的人使用了3- 一个月的健身训练期(1小时15分钟适中 3名监督有氧运动的强度运动和伸展 每周锻炼次数)，以及类似的9个月维护期 有监督的运动训练。我们将随机抽取176名男性(88名非洲人 美国人，88名非西班牙裔白人美国人)和88名女性(44名非洲人- 美国人，44名非西班牙裔白人美国人)对干预 条件或仅限评估的控制条件，并将进行 有氧健身、心理社会、精神病学、尿液和血液 研究开始时、3个月和12个月时的评估。这项研究扩展了 之前的工作是通过检查长期干预对 非洲裔和非西班牙裔美国白人男性和非西班牙裔美国人的情感和行为 正在应对艾滋病毒相关症状和压力源的妇女。一个 其他扩展涉及认知行为的使用 用于预防复发的修改包，以确定 有氧运动训练作为慢性阻塞性肺疾病长期治疗的可行性 HIV-1感染。

The proposed project extends our NIMH-funded studies of behavioral interventions for individuals with Human Immunodeficiency Virus-Type 1 (HIV-1) infection. These studies showed that a program of moderate aerobic exercise training for asymptomatic and healthy gay males, prior to receiving a positive HIV-1 diagnosis, lowered self-report levels of anxiety, depression, and helplessness, while maintaining active coping strategies and social support following news of seropositivity. The current 5-year prospective study will determine if similar benefits to mental health can be derived, from aerobic exercise training, by African- and nonHispanic White-American men and women, with early symptomatic HIV- 1 infection (World Health Organization stage-3; WHO, 1990) regardless of exposure category. To date, there have been no experimentally designed prospective stress management intervention studies with symptomatic pre- AIDS multiethnic men and women drawn across exposure category. This intervention, based on our experiences with aerobic exercise training in HIV-1 seropositive individuals over the past five years utilizes a 3- month fitness acquisition period (one hour and 15 minutes of moderate intensity exercise and stretching for each of 3 supervised aerobic exercise sessions per week) and a 9-month maintenance period of similar supervised exercise training. We will randomize 176 men (88 African American, 88 nonHispanic White American) and 88 women (44 African- American, 44 nonHispanic White-American) to either the intervention condition or an assessment-only control condition and will conduct aerobic fitness, psychosocial, psychiatric, urinary, and blood assessments at study entry, 3-months, and 12-months. This study extends previous work by examining the effects of a long term intervention on affect and behavior in African- and nonHispanic White-American men and women who are coping with HIV-related symptoms and stressors. An additional extension concerns the use of cognitive behavioral modification package for relapse prevention in order to determine the feasibility of aerobic exercise training as a long-term treatment for HIV-1 infection.