INTRAVASCULAR GELS FOR MODULATION OF ARTERIAL HEALING

用于调节动脉愈合的血管内凝胶

• 批准号: 2415691
• 负责人: JEFFREY A. HUBBELL
• 金额: $ 21.6万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2415691
• 关键词: artery; atherosclerosis; biomaterial development /preparation; biomaterial evaluation; biotransformation; blood circulation; cell adhesion molecules; cell cycle; disease /disorder model; fluorescence microscopy; gel; intraluminal angioplasty; laboratory rabbit; laboratory rat; platelet aggregation; platelet derived growth factor; polymers; protein transport; thrombin; thrombosis; vascular endothelium; vascular endothelium permeability; wound healing

DESCRIPTION: (Adapted from the applicant's abstract) The proposed work uses a novel technique to (1) investigate the basic biology of healing in balloon-angioplasty injury of arterial wall and (2) point the direction to new interventional therapies which will inhibit intimal hyperplasia and restenosis. In the first part of the project, blockade of platelet deposition will be used to investigate mechanisms of intimal thickening. The permeability of both thrombus-preventing and thrombus- inducing barriers will be varied to systematically investigate the role of circulating and thrombus-generated factors in a clean fashion. In the next part of the work, the protein release characteristics of the blockading gels will be investigated and the gels will be used to locally perturb healing by release of thrombin and PDGF, which are known to influence the healing process. Finally, endothelial-cell adhesion- promoting peptides will be incorporporated into degradable gels to develop a material which will enhance re-endothelialization of the injury site.

描述：（改编自申请人的摘要）拟议的工作 使用一种新的技术来（1）研究愈合的基本生物学 在球囊血管成形术损伤动脉壁和（2）点， 新的介入治疗的方向，这将抑制内膜 增生和再狭窄。 在项目的第一部分，封锁 血小板沉积将被用来研究内膜的机制， 增厚 血栓预防剂和血栓预防剂的渗透性均较低， 诱导障碍将是不同的，以系统地调查的作用， 循环和血栓产生的因素。 在 接下来的部分工作，蛋白质的释放特性， 将研究封锁凝胶，凝胶将用于局部 通过释放凝血酶和PDGF干扰愈合，已知凝血酶和PDGF 影响愈合过程。 最后，内皮细胞粘附- 促进肽将被掺入可降解凝胶中， 开发一种能增强损伤再内皮化的材料 绝佳的价钱