ION CHANNELS IN DROSOPHILA

研究建议：提出的研究是一个很好的系列， 实验首先，评估磷酸化在调节 果蝇钠通道的功能，并确定 果蝇神经元表达的离子通道的分子修饰 来自单个神经元的PCR产物的指纹图谱。这些研究 互补性很好：磷酸化和 果蝇帕拉钠交替剪接结构域的调控 通道是正在进行的研究的明确延伸，并利用 她所熟悉的最先进的技术，如单- 细胞PCR，而最后一个具体目标包括实验， 利用较少探索的技术，但可以提供重要的新的 信息，并为她提供数据，将继续她的研究 在发育过程中控制离子通道表达的领域。

RESEARCH PROPOSED: The research proposed is an excellent series of experiments to first, evaluate the role of phosphorylation in regulating the function of drosophila sodium channels, and the to determine the complement of ion channels expressed by drosophila neurons by molecular fingerprinting of PCR products from single neurons. These studies complement each other well: the studies on phosphorylation and regulation of alternately spliced domains of drosophila para sodium channels are a clear extension of the ongoing research, and utilize state-of-the-art techniques with which she is familiar, such as single- cell PCR, while the last specific aim consists of experiments that utilize less explored techniques, but could provide significant new information and provide her with data that would continue her research in the area of control of ion channel expression during development.