PREVENTIVE ONCOLOGY ACADEMIC AWARD

预防肿瘤学学术奖

• 批准号: 2443064
• 负责人: ANNE LINDSAY FRAZIER
• 金额: $ 8.98万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2443064
• 关键词: adolescence (12-20); alcoholism /alcohol abuse; cancer prevention; cancer risk; carcinogenesis; diet; female; fruit; human morbidity; human mortality; human subject; longitudinal human study; mathematical model; medical education; model design /development; neoplasm /cancer education; neoplasm /cancer epidemiology; nurses; nutrition related tag; oncology; science education; statistics /biometry; toxicology; vegetables; women's health

DESCRIPTION: (Adapted from Application) To prevent cancer, one must have identified the critical exposure. Increasing evidence suggest that childhood and adolescence are a particularly vulnerable period for mutagenic exposures. Furthermore, to motivate behavior change, one must effectively communicate risk. The specific research aims of this proposal are therefore to:1) Examine the relation between adolescent exposures and the subsequent development of adult malignancies. 2) To construct a model of overall cancer incidence and mortality that can be used to: a) define the attributable risk of each exposure, comparing adolescent versus adult exposures. b) define interactions between exposures (how much worse is one's risk of cancer if one never eats fruits or vegetables and is a heavy drinker?). c)estimate the efficacy of a cancer prevention intervention at both the individual and societal level. These objectives will be accomplished using the data collected by the Nurses' Health Study, a prospective cohort of 121,700 women prospectively followed since 1976. Extensive, validated data have been collected every two years on significant exposures, diet and incidence of disease. Follow-up of the initial cohort as of 1990 was over 91 percent.As a recipient of a Preventive Oncology Academic Award, I would seek more didactic training in the methods of epidemiology, biostatistics and risk modification at the Harvard School of Public Health to further refine my work in cancer prevention.

产品说明： （改编自Application） 为了预防癌症，我们必须 已经确定了关键的暴露点 越来越多的证据表明 儿童和青少年时期是一个特别脆弱的时期， 诱变暴露。 此外，为了激励行为改变， 必须有效沟通风险。 具体研究目标 因此，这项建议是：（1）审查 关系 青少年暴露和成年后的发育 恶性肿瘤。 2)构建一个癌症总体发病率模型， 死亡率，可用于：a）定义每种疾病的可归因风险 暴露，比较青少年与成人暴露。 B）定义 暴露之间的相互作用（一个人患癌症的风险有多大） 如果一个人从不吃水果或蔬菜，而且是一个酗酒者？）。 c）评估癌症预防干预在以下两个方面的功效： 个人和社会层面。 这些目标将 使用护士健康研究收集的数据完成， 一个前瞻性队列的121,700名妇女前瞻性地跟踪， 1976. 每两年收集一次广泛的、经过验证的数据， 年的显著暴露，饮食和疾病的发病率。 截至1990年，对初始队列的随访率超过91%。 获得预防肿瘤学学术奖，我将寻求 在流行病学、生物统计学方法方面进行更多的教学培训 哈佛大学公共卫生学院的风险调整， 完善我的癌症预防工作