EFFECTS OF TI02 CRYSTYAL STRUCTURE ON C3 ADSORPTION

这项资助的目的是研究不同的二氧化钛表面的影响。 关于C3从血浆中的吸附，参照确定什么 二氧化钛涂层的性能对牙体的生物相容性有重要影响 植入物。富含~(125)I标记C3的血浆将暴露于各种 二氧化钛表面包括：1)阳极，2)热，3)电抛光， 机械加工，锐钛矿型，金红石型。羟基磷灰石将被用作 控制面。曝光时间最初包括10、100、500、1000和 2000秒。曝光方案包括0.5、1.0、1.5、2.0和100% 血浆。C3表面浓度将由通过 伽马计数器。C3在二氧化钛表面的吸附动力学为 分析过了。未来的工作，不包括在这项赠款提案中，包括 对表面进行广泛的材质分析，并创建 蛋白质吸附与生物效应的数学模型 和材料变量。

The purpose of this grant is to study the effects of varying Ti02 surfaces on the adsorption of C3 from plasma, in reference to determining what properties of Ti02 layer are important to the biocompatibility of dental implants. Plasma enriched with 125I labeled C3 will be exposed to various Ti02 surfaces including; 1) anodic, 2) thermal, 3) electropolished, 4) machined, 5) anatase, 6) rutile. Hydroxyapatite will be used as a control surface. Exposure times include initially, 10, 100, 500, 1000 and 2000 seconds. Exposure solutions include 0.5, 1.0, 1.5, 2.0 and 100% plasma. C3 surface concentrations will be measured from cpm obtained via a gamma counter. The kinetics of C3 adsorption on Ti02 surfaces will be analyzed. Future work, not included in this grant proposal, includes extensive materials analysis of the surfaces and the creation of a mathematical model of protein adsorption as a function of both biological and materials variables.