EFFECTS OF TI02 CRYSTYAL STRUCTURE ON C3 ADSORPTION

TI02晶体结构对C3吸附的影响

• 批准号: 3425519
• 负责人: MONA E MCALARNEY
• 金额: $ 2.23万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-08-01 至 1992-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3425519
• 关键词: adsorption; complement receptor; computer simulation; endosseous dental implant; hydroxyapatites; mathematical model; plasma; radiotracer; titanium

The purpose of this grant is to study the effects of varying Ti02 surfaces on the adsorption of C3 from plasma, in reference to determining what properties of Ti02 layer are important to the biocompatibility of dental implants. Plasma enriched with 125I labeled C3 will be exposed to various Ti02 surfaces including; 1) anodic, 2) thermal, 3) electropolished, 4) machined, 5) anatase, 6) rutile. Hydroxyapatite will be used as a control surface. Exposure times include initially, 10, 100, 500, 1000 and 2000 seconds. Exposure solutions include 0.5, 1.0, 1.5, 2.0 and 100% plasma. C3 surface concentrations will be measured from cpm obtained via a gamma counter. The kinetics of C3 adsorption on Ti02 surfaces will be analyzed. Future work, not included in this grant proposal, includes extensive materials analysis of the surfaces and the creation of a mathematical model of protein adsorption as a function of both biological and materials variables.

这项资助的目的是研究不同TiO2表面的影响 关于从血浆中吸附C3， TiO2层的性能对牙科生物相容性很重要， 植入物. 富含125I标记的C3的血浆将暴露于各种环境中。 TiO2表面包括：1）阳极，2）热，3）电抛光， 4)机械加工的，5）金红石，6）金红石。 羟基磷灰石将被用作 控制面 暴露时间包括最初的10、100、500、1000和 两千秒。 暴露溶液包括0.5、1.0、1.5、2.0和100% 等离子体 C3表面浓度将根据通过 伽玛计数器 C3在TiO2表面上吸附的动力学将为： 分析了 未来的工作不包括在本资助提案中，包括 对表面进行广泛的材料分析， 蛋白质吸附的数学模型作为生物学和生物学的函数， 和材料变量。