BASAL FOREBRAIN--ANATOMY TO FUNCTION

拟议的专题讨论会的目标是综合目前的研究结果 关于基底前脑的解剖和功能， 增加我们对中枢神经系统这个复杂区域的了解 系统 近年来，有关的研究有了令人瞩目的增长 与基底前脑的神经元系统相关联。 这种增长发现其 当代观察的推动力，基底前脑核是 参与动物互动所必需的高阶功能 与环境相适应。 这些功能包括奖励， 感知、学习和记忆，以及各种运动行为。 因此 在这次研讨会上，将给予相当大的关注， 基底前脑的特征 解剖学评估揭示了神经系统和 神经传递素。 有大量的文献 然而，描述了含乙酰胆碱的传出投射， 对基底前脑的输入知之甚少。 这 因此，研讨会也将强调传入对已知输出的影响 的基底前脑，重点放在神经元整合。 最终，基底前脑的临床前评估应该摆脱 对人类状况的了解，特别是那些 基底前脑功能障碍的表现。 因此，研讨会将 最后总结一下表现为痴呆的神经系统疾病。 将对那些尚未得到充分重视的疾病给予相当大的注意。 也是其他研究的主题，例如帕金森氏痴呆症。 该计划已被设计，以便讨论，其中跨越几个 各种技术专长将在 神经科学家 希望这将促进一个综合的 解释最近的实验室和临床观察结果。 仅与 这种多学科的互动可以试图阐明整体 基底前脑功能和功能障碍的图片。

It is the goal of the proposed symposium to integrate current findings regarding the anatomy and function of the basal forebrain and thus to increase our understanding of this complex region of the central nervous system. Recent years have witnessed and impressive growth in research concerned with neuronal systems of the basal forebrain. This growth finds its impetus in contemporary observations that basal forebrain nuclei are involved in higher order functions necessary for the animal to interact appropriately with its environment. These functions include reward, perception, learning and memory, and a variety of motoric behaviors. Thus in this symposium, considerable attention will be given to the functional attributes of the basal forebrain. Anatomical evaluations reveal a complex interplay of neuronal systems and neurotransmitters in this brain region. There is a wealth of literature describing the acetylcholine-containing efferent projections, however, relatively little is known about inputs to the basal forebrain. This symposium, therefore, also will stress afferent influences on known outputs of the basal forebrain, with focus being placed on neuronal integration. Ultimately, preclinical evaluations of the basal forebrain should shed light on the human condition, specifically those situations which are a manifestation of basal forebrain dysfunction. Thus, the symposium will close with a summary on neurological disorders which express dementia. Considerable attention will be given to those disorders which have not yet been the subject of other reviews, for example, Parkinsonian dementia. The program has been designed so that discussion which crosses several lines of diverse technical expertise will develop among the neuroscientists. It is hoped that this will foster an integrative interpretation of recent laboratory and clinical observations. Only with such multidisciplinary interactions can one attempt to elucidate the whole picture of basal forebrain function and dysfunction.