减少肾纤维化的新策略-猫眼课题宝

减少肾纤维化的新策略

批准号：

nhmrc : 1010098

负责人：

Dr Zemin Cao

金额：

$38.56万

依托单位：

Baker IDI Heart and Diabetes Institute

依托单位国家：

澳大利亚

项目类别：

NHMRC Project Grants

财政年份：

2011

资助国家：

澳大利亚

项目状态：

已结题

起止时间：

2011-01-01 至 2013-12-31

来源：

https://researchdata.edu.au/novel-strategy-reduce-renal-fibrosis/109460

关键词：

Novel strategy reduce renal fibrosis

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英文摘要

Kidney fibrosis is a serious complication seen in diabetic subjects. This process is mainly controlled by transforming growth factor beta (TGF-beta). However, direct targeting of TGF-beta as a therapeutic approach is inappropriate due to its other important functions. Our preliminary data show that Cell Division Autoantigen 1 (CDA1) is critical for the disease causing activity of TGF-beta. We propose to use our recently generated unique CDA1 gene knockout mouse to demonstrate this important role of CDA1.

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