The role of exercise in vaccine-mediated immunity

运动增强疫苗诱导的抗原特异性T细胞应答常规中度 运动已被提出来增强免疫功能，但它对免疫力的影响及其 其后果尚未得到充分研究。未获得（AL）或获得（AL + EX）的小鼠 通过鼻内途径用模型抗原（卵清蛋白（OVA））接种自愿跑步轮 或皮下途径分别靶向粘膜和全身免疫区室。 EX增强所有淋巴细胞中OVA特异性CD 4 + T细胞细胞因子的产生和增殖 检查的器官中没有任何器官中细胞分布的变化。这些结果表明 适度运动与疫苗接种相结合可提高疫苗的预防效果， 和/或多种疾病的治疗。在另一项研究中，能量限制和运动 差异增强小鼠的全身和粘膜免疫组分。之时尚 肥胖是包括癌症在内的几种慢性病的既定危险因素， 在过去的四十年里，饮食改变和/或增加体力活动是 最常推荐的预防或逆转肥胖的基于生活方式的策略。 饮食改变和锻炼可以增强几个生理系统之一， 免疫系统.本研究探讨了能量限制（ER;减少30%）的影响 相对于对照能量摄入）和/或EX（自行车轮运行）对全身和粘膜的影响 免疫功能将雌性C57 BL/6小鼠随机分为四种处理条件： 对照组，自由进食（AL）; 2）AL，可使用转轮（AL+EX）; 3）30% ER;和4）30% ER，可接近运行轮（ER+EX）。ER和EX均降低脾脏重量 脾T、B淋巴细胞数（p <0.05）。ER增强NK细胞功能， 但显著降低Con A诱导的T细胞增殖（p <0.05）。相比之下，EX 显著增强ConA诱导的Peyers集合淋巴结增殖和细胞因子产生 细胞（p <0.05）。这些数据表明，ER和EX增强了一些，但不是所有组件 免疫系统，并可能通过不同的生物机制来调节 NK和T细胞功能。

Exercise enhances vaccine-induced antigen-specific T cell responses. Regular moderate exercise has been proposed to enhance immune function, but its effects on immunity and their consequences have not been well studied. Mice without (AL) or with access (AL + EX) to voluntary running wheels were vaccinated with a model antigen (ovalbumin (OVA)) via intranasal or subcutaneous routes to target the mucosal and systemic immune compartments, respectively. EX-enhanced OVA-specific CD4+ T cell cytokine production and proliferation in all lymphoid organs examined without changes in cell distribution in any organ. These results suggest that coupling moderate exercise with vaccination may enhance vaccine efficacy for the prevention and/or therapy of numerous diseases. In another study, energy restriction and exercise differentially enhance components of systemic and mucosal immunity in mice. The prevalence of obesity, an established risk factor for several chronic diseases including cancer, has risen dramatically over the past four decades. Dietary change and/or increased physical activity are the most commonly recommended lifestyle-based strategies for preventing or reversing obesity. One of several physiological systems that may be enhanced by dietary change and exercise is the immune system. This study examines the effects of energy restriction (ER; 30% reduction relative to control energy intake) and/or EX (voluntary-wheel running) on systemic and mucosal immune function. Female C57BL/6 mice were randomized into four treatment conditions: 1) controls consuming food ad libitum (AL); 2) AL with access to running wheels (AL+EX); 3) 30% ER; and 4) 30% ER with access to running wheels (ER+EX). Both ER and EX reduced spleen weight and the number of splenic T and B lymphocytes (p less than 0.05). ER enhanced NK cell function, but significantly reduced Con A-induced T cell proliferation (p less than 0.05). In contrast, EX significantly enhanced Con A-induced proliferation and cytokine production from Peyers patch cells (p less than 0.05). These data suggest that ER and EX enhance some, but not all components of the immune system, and are likely working via different biological mechanisms to regulate NK and T cell function.