Novel ways of utilizing genome-wide DNA methylation data from peripheral blood samples in genetic epidemiology

在遗传流行病学中利用外周血样本全基因组 DNA 甲基化数据的新方法

• 批准号: nhmrc : 1085130
• 负责人: Prof Caroline Relton
• 金额: $ 19.02万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-ways-utilizing-genetic-epidemiology/519061
• 关键词: Novel; ways; utilizing; genome; wide

The aim of this project is to develop statistical methods and paradigms to better leverage the considerable amount of peripheral blood DNA methylation data that has been collected from large scale epidemiological studies. In particular, our focus is on developing and optimizing statistical methods of using DNA methylation profiles to “tag” environmental exposures, so that this information can be better utilized to investigate the genetic and environmental basis of complex traits and diseases.

该项目的目的是开发统计方法和范例，以更好地利用从大规模流行病学研究中收集的大量外周血DNA甲基化数据。特别是，我们的重点是开发和优化使用DNA甲基化谱的统计方法来“标记”环境暴露，使这些信息可以更好地利用调查复杂的性状和疾病的遗传和环境基础。