Advances in Research Basic Science Symposium on "Epigenetics: Regulating the Geno

描述（由申请人提供）：表观遗传学是对细胞或生物体基因组中未编码的遗传性状的研究。这种遗传可以通过种系或从母细胞到子细胞。因此，表观遗传原理是生物学中许多基本过程的基础，例如维持分化状态、干细胞多能性和基因组调控。在过去的十年中，人们在了解表观遗传的生化基础方面取得了显着的进展。现在已知某些组蛋白残基的修饰与染色质结构域的结构和表达相关。事实上，基因组可以根据印在核体和 DNA 上的“表观遗传密码”分为活性区域和抑制区域。模型生物的遗传学研究与基础生物化学相结合，揭示了 Polycomb 和 Trithorax 介导的表观遗传调控对组蛋白修饰状态的直接作用。这些迅速出现的发现影响着人类发育、衰老和疾病的各个方面。 ASN 会议“表观遗传学：调控发育和疾病中的基因组”将为我们的成员和其他感兴趣的各方提供一个论坛，以了解从事表观遗传学研究的世界领导人的新兴概念和技术。因此，我们期望促进表观遗传学研究的重大兴趣和潜在整合到与肾脏领域临床相关的领域，例如衰老、糖尿病、再生和干细胞生物学。我们特别鼓励新教师和学员参加，并将从此应用程序支持的旅行奖励中受益匪浅。

DESCRIPTION (provided by applicant): Epigenetics is the study of inherited traits that are not encoded in the genome of cells or organisms. Such inheritance could be through the germline or from a mother cell to a daughter cell. As such, epigenetic principles underlie many fundamental processes in biology, such as maintaining a differentiated state, stem cell pluripotency, and regulation of the genome. Over the past ten years, remarkable progress has been made in understanding the biochemical basis of epigenetic inheritance. The modification of certain histone residues is now known to correlate with the structure and expression of chromatin domains. Indeed, the genome can be compartmentalized into active and repressed regions based upon an "epigenetic code" imprinted onto nuclesomes and DNA. Genetic studies in model organisms converged with basic biochemistry to reveal a direct role for Polycomb and Trithorax mediated epigenetic regulation on the status of histone modification. These rapidly emerging discoveries impact all aspects of human development, aging, and disease. The ASN conference on "Epigenetics: regulating the genome in development and disease" will provide a forum for our members and other interested parties to learn about emerging concepts and technologies from world leaders engaged in epigenetic research. As such, we expect to promote significant interest and potential integration of epigenetic research into areas of clinical relevance to the renal field, such as aging, diabetes, regeneration, and stem cell biology. New faculty and trainees are particularly encouraged to attend and will benefit greatly from the travel awards supported by this application.