Advances in Research Basic Science Symposium on "Epigenetics: Regulating the Geno

“表观遗传学：调控基因组”基础科学研究进展研讨会

• 批准号: 7800852
• 负责人: Gregory R Dressler
• 金额: $ 1.2万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7800852
• 关键词: Aging; American; Animal Model; Area; Arts; Award; Basic Science; Biochemical; Biochemistry; Biology; Cells; Chromatin; Clinical; Code; Collaborations; DNA; Development; Diabetes Mellitus; Disease; Drug Formulations; Epigenetic Process; Event; Faculty; Fostering; Functional RNA; Funding; Future; Genetic; Genome; Goals; Histones; Human Development; Inherited; Investigation; Kidney; Kidney Diseases; Learning; Mediating; Modification; Mothers; Natural regeneration; Nephrology; Organism; Participant; Polycomb; Postdoctoral Fellow; Process; Regulation; Research; Research Personnel; Role; Schedule; Scientist; Societies; Stem Cell Development; Stem cells; Structure; Technology; Time; Travel; Work; base; clinically relevant; daughter cell; design; graduate student; histone modification; human disease; imprint; interest; meetings; member; novel strategies; pluripotency; stem cell biology; symposium; trait

DESCRIPTION (provided by applicant): Epigenetics is the study of inherited traits that are not encoded in the genome of cells or organisms. Such inheritance could be through the germline or from a mother cell to a daughter cell. As such, epigenetic principles underlie many fundamental processes in biology, such as maintaining a differentiated state, stem cell pluripotency, and regulation of the genome. Over the past ten years, remarkable progress has been made in understanding the biochemical basis of epigenetic inheritance. The modification of certain histone residues is now known to correlate with the structure and expression of chromatin domains. Indeed, the genome can be compartmentalized into active and repressed regions based upon an "epigenetic code" imprinted onto nuclesomes and DNA. Genetic studies in model organisms converged with basic biochemistry to reveal a direct role for Polycomb and Trithorax mediated epigenetic regulation on the status of histone modification. These rapidly emerging discoveries impact all aspects of human development, aging, and disease. The ASN conference on "Epigenetics: regulating the genome in development and disease" will provide a forum for our members and other interested parties to learn about emerging concepts and technologies from world leaders engaged in epigenetic research. As such, we expect to promote significant interest and potential integration of epigenetic research into areas of clinical relevance to the renal field, such as aging, diabetes, regeneration, and stem cell biology. New faculty and trainees are particularly encouraged to attend and will benefit greatly from the travel awards supported by this application.

描述(申请人提供)：表观遗传学是对细胞或生物体基因组中未编码的遗传特征的研究。这样的遗传可能是通过生殖系或从母细胞到子细胞。因此，表观遗传学原理构成了生物学中许多基本过程的基础，如维持分化状态、干细胞多能性和基因组调控。在过去的十年里，在理解表观遗传的生化基础方面取得了显著的进展。现在已知某些组蛋白残基的修饰与染色质结构域的结构和表达有关。事实上，基因组可以根据印在核体和DNA上的“表观遗传密码”被划分为活跃和受抑制的区域。模式生物中的遗传学研究与基础生物化学相结合，揭示了Polycomb和Trithorax介导的表观遗传调控对组蛋白修饰状态的直接作用。这些迅速出现的发现影响到人类发展、老龄化和疾病的方方面面。ASN关于“表观遗传学：调控发育和疾病中的基因组”的会议将为我们的成员和其他感兴趣的各方提供一个论坛，从从事表观遗传学研究的世界领导人那里了解新兴的概念和技术。因此，我们希望促进表观遗传学研究在与肾脏领域临床相关的领域，如衰老、糖尿病、再生和干细胞生物学等领域的显著兴趣和潜在的整合。特别鼓励新教师和实习生参加，并将从本申请支持的旅行奖励中受益匪浅。