GENETIC RECOMBINATION & GENOME REARRANGEMENTS

描述(申请人提供)：本申请寻求部分支持美国实验生物学学会联合会(FASEB)关于基因重组和基因组重排的会议，会议将于2009年8月2-7日在科罗拉多州的斯诺马斯举行。2009年遗传重组和染色体重组会议将是专门讨论这些专题的一系列非常成功的两年一度的会议中的第十三次。这次会议的目的是与研究人员一起研究基因重组的许多不同方面，在一系列生物系统中，并使用不同的实验方法。演讲将介绍关于实地及时问题的新的和未发表的工作，并将包括所有参与者的讨论。FASEB会议为交流信息和技术提供了独特的机会，可以在整个重组领域欣赏和利用这些信息和技术。 重组在控制人类和所有其他生物的遗传稳定性方面起着重要的作用。一些人类易患癌症的综合征，如毛细血管扩张性共济失调(A-T)、奈梅根断裂综合征(NBS)和A-T样紊乱(A-TLD)，都是由双链断裂修复缺陷引起的，这一发现突显了这一途径在维持基因组完整性和避免癌症方面的重要性。此外，BRCA2基因的产物直接与RAD51相互作用，对于同源重组是必不可少的。BRCA2基因在遗传性乳腺癌的一个子集中突变。许多受邀的演讲者将讨论在这些人类癌症易发综合征中有缺陷的蛋白质在基因组稳定性和对环境诱变剂的抵抗力中所起的作用。为了提供信息和加强哺乳动物的研究，将介绍细菌、酵母、拟南芥、果蝇、线虫和非洲爪哇等模型系统的相关蛋白质和机制的工作。会议的大部分时间将集中在国家癌症研究所关注的话题上。 公共卫生相关性：同源重组的DNA修复在控制所有生物的遗传稳定性方面发挥着重要作用。一些人类癌症易感综合征的发现，如毛细血管扩张性共济失调(A-T)、遗传性乳腺癌(BRCA1或BRCA2)和Bloom综合征都是由DNA重组/修复缺陷引起的，这一发现突显了这一途径在维持基因组完整性和避免癌症方面的重要性。这次会议聚集了研究重组机制的主要研究人员，目的是进一步了解重组如何有助于基因组的稳定性。

DESCRIPTION (provided by applicant): This application seeks partial support for the Federation of American Societies of Experimental Biology (FASEB) conference on Genetic Recombination and Genome Rearrangements to be held August 2-7, 2009 in Snowmass, Colorado. The 2009 Conference on Genetic Recombination and Chromosome Rearrangements will be the thirteenth in a series of highly successful bi-annual conferences devoted to these topics. This conference aims to join investigators studying many diverse aspects of genetic recombination, in a range of biological systems and with different experimental approaches. Presentations will introduce new and unpublished work on timely questions in the field and will include discussion from all participants. The FASEB conference provides unique opportunities for the exchange of information and technology that can be appreciated and exploited across the recombination field. Recombination plays an important role in the control of genetic stability in human as well as all other living organisms. The discovery that several human cancer prone syndromes, for example, Ataxia Telangiectasia (A-T), Nijmegen Breakage Syndrome (NBS) and A-T like disorder (A-TLD), are caused by defects in double-strand break repair has highlighted the importance of this pathway in maintaining genome integrity and cancer avoidance. Furthermore, the product of the BRCA2 gene, which is mutated in a subset of hereditary breast cancers, interacts directly with Rad51 and is essential for homologous recombination. Many of the invited speakers will discuss the role of proteins defective in these human cancer prone syndromes in genome stability and resistance to environmental mutagens. To inform and augment studies from mammals, work concerning related proteins and mechanisms from model systems of bacteria, yeast, Arabidopsis, Drosophila, C. elegans and Xenopus will be featured. Much of the conference will be devoted to topics of concern to the National Cancer. Public Health Relevance: DNA repair by homologous recombination plays an important role in the control of genetic stability in all living organisms. The discovery that several human cancer prone syndromes, for example, Ataxia Telangiectasia (A-T), hereditary forms of breast cancer (BRCA1 or BRCA2) and Bloom's syndrome are caused by defects in the DNA recombination/repair has highlighted the importance of this pathway in maintaining genome integrity and cancer avoidance. This conference brings together the principal investigators studying the mechanisms of recombination with the goal of further understanding how recombination contributes to genome stability.