GENETIC RECOMBINATION & GENOME REARRANGEMENTS

描述（由申请人提供）：本申请寻求对将于2009年8月2日至7日在科罗拉多斯诺马斯举行的美国实验生物学学会联合会（FASEB）遗传修饰和基因组重排会议的部分支持。2009年遗传修饰和染色体重排会议将是专门讨论这些主题的一系列非常成功的两年期会议中的第十三次。本次会议的目的是加入研究遗传重组的许多不同方面的研究人员，在一系列生物系统和不同的实验方法。演讲将介绍关于该领域及时问题的新的和未发表的工作，并将包括所有与会者的讨论。FASEB会议为信息和技术的交流提供了独特的机会，这些信息和技术可以在重组领域得到赞赏和利用。 在控制人类以及所有其他生物体的遗传稳定性方面，突变起着重要作用。一些人类癌症易感综合征，例如共济失调毛细血管扩张症（A-T）、奈梅亨断裂综合征（NBS）和A-T样病症（A-T），是由双链断裂修复缺陷引起的，这一发现突出了该途径在维持基因组完整性和癌症避免中的重要性。此外，BRCA 2基因的产物在遗传性乳腺癌的一个子集中突变，直接与Rad 51相互作用，并且对于同源重组是必需的。许多受邀的演讲者将讨论这些人类癌症易感综合征中蛋白质缺陷在基因组稳定性和对环境诱变剂的抗性中的作用。为丰富哺乳动物的研究，对细菌、酵母、拟南芥、果蝇、C. elegans和Xenopus将被展出。会议的大部分时间将专门讨论国家癌症委员会关心的问题。 公共卫生相关性：通过同源重组进行的DNA修复在控制所有生物体的遗传稳定性方面发挥着重要作用。发现几种人类癌症倾向综合征，例如共济失调毛细血管扩张症（A-T）、遗传性形式的乳腺癌（BRCA 1或BRCA 2）和布卢姆综合征是由DNA重组/修复中的缺陷引起的，这突出了该途径在维持基因组完整性和癌症避免中的重要性。本次会议汇集了研究重组机制的主要研究人员，目的是进一步了解重组如何有助于基因组稳定性。

DESCRIPTION (provided by applicant): This application seeks partial support for the Federation of American Societies of Experimental Biology (FASEB) conference on Genetic Recombination and Genome Rearrangements to be held August 2-7, 2009 in Snowmass, Colorado. The 2009 Conference on Genetic Recombination and Chromosome Rearrangements will be the thirteenth in a series of highly successful bi-annual conferences devoted to these topics. This conference aims to join investigators studying many diverse aspects of genetic recombination, in a range of biological systems and with different experimental approaches. Presentations will introduce new and unpublished work on timely questions in the field and will include discussion from all participants. The FASEB conference provides unique opportunities for the exchange of information and technology that can be appreciated and exploited across the recombination field. Recombination plays an important role in the control of genetic stability in human as well as all other living organisms. The discovery that several human cancer prone syndromes, for example, Ataxia Telangiectasia (A-T), Nijmegen Breakage Syndrome (NBS) and A-T like disorder (A-TLD), are caused by defects in double-strand break repair has highlighted the importance of this pathway in maintaining genome integrity and cancer avoidance. Furthermore, the product of the BRCA2 gene, which is mutated in a subset of hereditary breast cancers, interacts directly with Rad51 and is essential for homologous recombination. Many of the invited speakers will discuss the role of proteins defective in these human cancer prone syndromes in genome stability and resistance to environmental mutagens. To inform and augment studies from mammals, work concerning related proteins and mechanisms from model systems of bacteria, yeast, Arabidopsis, Drosophila, C. elegans and Xenopus will be featured. Much of the conference will be devoted to topics of concern to the National Cancer. Public Health Relevance: DNA repair by homologous recombination plays an important role in the control of genetic stability in all living organisms. The discovery that several human cancer prone syndromes, for example, Ataxia Telangiectasia (A-T), hereditary forms of breast cancer (BRCA1 or BRCA2) and Bloom's syndrome are caused by defects in the DNA recombination/repair has highlighted the importance of this pathway in maintaining genome integrity and cancer avoidance. This conference brings together the principal investigators studying the mechanisms of recombination with the goal of further understanding how recombination contributes to genome stability.